{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3TMP8","secondaryAccessions":["A5A6S4","A7LBB7","Q3TZB9","Q91WL2"],"uniProtkbId":"TM38A_MOUSE","entryAudit":{"firstPublicDate":"2007-01-09","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-09","entryVersion":129,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Trimeric intracellular cation channel type A"},"shortNames":[{"value":"TRIC-A"},{"value":"TRICA"}]},"alternativeNames":[{"fullName":{"value":"27 kDa sarcoplasmic reticulum protein"}},{"fullName":{"value":"Mitsugumin-33A"}},{"fullName":{"value":"SPR-27"}},{"fullName":{"value":"Transmembrane protein 38A"}}]},"genes":[{"geneName":{"value":"Tmem38a"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5A6S6"}],"value":"Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Opened by a change of voltage within the sarcoplasmic reticulum lumen"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5A6S6"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5A6S6"}],"value":"Channel activity is activated by a change of voltage within the sarcoplasmic reticulum lumen and blocked by luminal high Ca(2+) levels"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5A6S6"}],"value":"Homotrimer; conformation seems to be controlled by binding to diacylglycerol (DAG)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5A6S6"}],"value":"Sarcoplasmic reticulum membrane","id":"SL-0241"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5A6S6"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5A6S6"}],"value":"Nucleus membrane","id":"SL-0182"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17611541"}],"value":"Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17611541"}],"value":"Mice are viable. Mice lacking Tmem38a and Tmem38b show a weak heartbeat at E9.5 followed by loss of cardiomyocyte viability and embryonic lethality around 10.5 dpc"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM38 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Trimeric intracellular cation channel type A","featureId":"PRO_0000271069"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Helical;Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Helical;Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Helical;Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Helical;Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Helical;Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Helical;Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Helical;Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5ZK43"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58456"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NA73"}],"ligand":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)","id":"ChEBI:CHEBI:58456"}},{"type":"Binding site","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58456"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NA73"}],"ligand":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)","id":"ChEBI:CHEBI:58456"}},{"type":"Sequence conflict","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in Ref. 3; BAE38393","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in Ref. 2; ABS17665 and 3; BAE34290","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0630","category":"Ligand","name":"Potassium"},{"id":"KW-0631","category":"Molecular function","name":"Potassium channel"},{"id":"KW-0633","category":"Biological process","name":"Potassium transport"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0703","category":"Cellular component","name":"Sarcoplasmic reticulum"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"17611541","citationType":"journal article","authors":["Yazawa M.","Ferrante C.","Feng J.","Mio K.","Ogura T.","Zhang M.","Lin P.-H.","Pan Z.","Komazaki S.","Kato K.","Nishi M.","Zhao X.","Weisleder N.","Sato C.","Ma J.","Takeshima H."],"citationCrossReferences":[{"database":"PubMed","id":"17611541"},{"database":"DOI","id":"10.1038/nature05928"}],"title":"TRIC channels are essential for Ca2+ handling in intracellular stores.","publicationDate":"2007","journal":"Nature","firstPage":"78","lastPage":"82","volume":"448"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TOPOLOGY","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE"]},{"referenceNumber":2,"citation":{"id":"CI-90U6IQ5IBGNIJ","citationType":"submission","authors":["Bleunven C.","Treves S.","Leo E.","Ronjat M.","De Waard M.","Kern G.","Flucher B.E.","Zorzato F."],"title":"SPR-27 is a novel component of the supramolecular signaling complex involved in skeletal muscle excitation-contraction coupling.","publicationDate":"JUN-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Cerebellum","type":"TISSUE"},{"value":"Inner ear","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Heart","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB261158","properties":[{"key":"ProteinId","value":"BAF62541.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF988666","properties":[{"key":"ProteinId","value":"ABS17665.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK157969","properties":[{"key":"ProteinId","value":"BAE34290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK165818","properties":[{"key":"ProteinId","value":"BAE38393.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC014728","properties":[{"key":"ProteinId","value":"AAH14728.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC024788","properties":[{"key":"ProteinId","value":"AAH24788.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS22417.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_653117.1","properties":[{"key":"NucleotideSequenceId","value":"NM_144534.2"}]},{"database":"AlphaFoldDB","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q3TMP8","properties":[{"key":"Number of interactors","value":"825"}]},{"database":"STRING","id":"10090.ENSMUSP00000034244","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.62.1.1","properties":[{"key":"FamilyName","value":"the homotrimeric cation channel (tric) family"}]},{"database":"GlyGen","id":"Q3TMP8","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000034244","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"259227","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27435","properties":[{"key":"antibodies","value":"131 antibodies from 26 providers"}]},{"database":"DNASU","id":"74166","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000034244.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000034244.8"},{"key":"GeneId","value":"ENSMUSG00000031791.9"}]},{"database":"GeneID","id":"74166","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:74166","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009mgi.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1921416","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79041","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1921416","properties":[{"key":"GeneName","value":"Tmem38a"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000031791","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3944","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000018845","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_076376_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FSKMAMF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"195817at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"74166","properties":[{"key":"hits","value":"1 hit in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q3TMP8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"Q3TMP8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000031791","properties":[{"key":"ExpressionPatterns","value":"Expressed in interventricular septum and 237 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q3TMP8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0016529","properties":[{"key":"GoTerm","value":"C:sarcoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0033017","properties":[{"key":"GoTerm","value":"C:sarcoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0015269","properties":[{"key":"GoTerm","value":"F:calcium-activated potassium channel activity"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"19095005"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0005267","properties":[{"key":"GoTerm","value":"F:potassium channel activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0071313","properties":[{"key":"GoTerm","value":"P:cellular response to caffeine"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0007029","properties":[{"key":"GoTerm","value":"P:endoplasmic reticulum organization"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0071805","properties":[{"key":"GoTerm","value":"P:potassium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0010881","properties":[{"key":"GoTerm","value":"P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0051279","properties":[{"key":"GoTerm","value":"P:regulation of release of sequestered calcium ion into cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0014808","properties":[{"key":"GoTerm","value":"P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"17611541"}]},{"database":"GO","id":"GO:0055085","properties":[{"key":"GoTerm","value":"P:transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17611541"}]},{"database":"InterPro","id":"IPR007866","properties":[{"key":"EntryName","value":"TRIC_channel"}]},{"database":"PANTHER","id":"PTHR12454","properties":[{"key":"EntryName","value":"TRIMERIC INTRACELLULAR CATION CHANNEL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12454:SF3","properties":[{"key":"EntryName","value":"TRIMERIC INTRACELLULAR CATION CHANNEL TYPE A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05197","properties":[{"key":"EntryName","value":"TRIC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDLMSALSLGELALSFSRVPLFPVFDLSYFIVSIIYLKYEPGAVELSRRHPVASWLCAMLHCFGSYILADLLLGEPIIDYFSNSSSILLASGVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFIMIATGWVKGSGVALLSNVEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFVFTMFMVSCKVFLTATHSHSSPFDILEGYICPVLFGATWGGDHHHDNHGAPHGMGLGTQHSGLPAKAKEELGEGSRKKKTKKAD","length":298,"molWeight":33309,"crc64":"F35559581DA80BD7","md5":"E48CDFBDF235C646BD3C961C36EDB228"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Region":1,"Compositional bias":1,"Binding site":3,"Sequence conflict":2},"uniParcId":"UPI00000238A4"}}