{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3TBL6","uniProtkbId":"TP8L3_MOUSE","entryAudit":{"firstPublicDate":"2008-04-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-10-11","entryVersion":126,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tumor necrosis factor alpha-induced protein 8-like protein 3"},"shortNames":[{"value":"TNF alpha-induced protein 8-like protein 3"},{"value":"TNFAIP8-like protein 3"}]}},"genes":[{"geneName":{"value":"Tnfaip8l3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"value":"Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"value":"On PDGF activation, translocates from cytoplasm to plasma membrane"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25479791"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25479791"}],"value":"Widely expressed (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"value":"The N-terminal domain (AA 2-20) is essential for its effect on cell growth and survival"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25479791"}],"value":"Deficient mice develop normally during the first 3 months of life under pathogen-free conditions. However, following subcutaneous injection of the carcinogen 3-methylcholanthrene, deficient mice exhibit markedly delayed skin tumor onset and reduced tumor size compared with wild-type mice"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TNFAIP8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Tumor necrosis factor alpha-induced protein 8-like protein 3","featureId":"PRO_0000331425"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Binding to phosphoinositides"},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Mutagenesis","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Reduces binding to phosphoinositide; when associated with Gln-34; Gln-38 and Gln-42.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Reduces binding to phosphoinositide; when associated with Gln-33; Gln-38 and Gln-42.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-42.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-38.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Reduces binding to phosphoinositide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["W"]}},{"type":"Mutagenesis","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Reduces binding to phosphoinositide; when associated with Gln-109.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Reduces binding to phosphoinositide; when associated with Gln-93.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25242044"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0445","category":"Biological process","name":"Lipid transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"NOD","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"25242044","citationType":"journal article","authors":["Fayngerts S.A.","Wu J.","Oxley C.L.","Liu X.","Vourekas A.","Cathopoulis T.","Wang Z.","Cui J.","Liu S.","Sun H.","Lemmon M.A.","Zhang L.","Shi Y.","Chen Y.H."],"citationCrossReferences":[{"database":"PubMed","id":"25242044"},{"database":"DOI","id":"10.1016/j.ccr.2014.07.025"}],"title":"TIPE3 is the transfer protein of lipid second messengers that promote cancer.","publicationDate":"2014","journal":"Cancer Cell","firstPage":"465","lastPage":"478","volume":"26"},"referencePositions":["TISSUE SPECIFICITY","FUNCTION","DISRUPTION PHENOTYPE","MUTAGENESIS OF LYS-33; LYS-34; LYS-38; LYS-42; LEU-60; ARG-93 AND ARG-109","SUBCELLULAR LOCATION"]},{"referenceNumber":5,"citation":{"id":"25479791","citationType":"journal article","authors":["Cui J.","Hao C.","Zhang W.","Shao J.","Zhang N.","Zhang G.","Liu S."],"citationCrossReferences":[{"database":"PubMed","id":"25479791"},{"database":"DOI","id":"10.1369/0022155414564871"}],"title":"Identical expression profiling of human and murine TIPE3 protein reveals links to its functions.","publicationDate":"2015","journal":"J. Histochem. Cytochem.","firstPage":"206","lastPage":"216","volume":"63"},"referencePositions":["TISSUE SPECIFICITY","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK170374","properties":[{"key":"ProteinId","value":"BAE41754.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK171174","properties":[{"key":"ProteinId","value":"BAE42293.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC118003","properties":[{"key":"ProteinId","value":"AAI18004.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC119769","properties":[{"key":"ProteinId","value":"AAI19770.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS40641.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001028707.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001033535.3"}]},{"database":"AlphaFoldDB","id":"Q3TBL6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q3TBL6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"232698","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q3TBL6","properties":[{"key":"Number of interactors","value":"1425"}]},{"database":"STRING","id":"10090.ENSMUSP00000096356","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q3TBL6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q3TBL6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000096356","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"297500","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"57338","properties":[{"key":"antibodies","value":"86 antibodies from 22 providers"}]},{"database":"Ensembl","id":"ENSMUST00000098760.5","properties":[{"key":"ProteinId","value":"ENSMUSP00000096356.4"},{"key":"GeneId","value":"ENSMUSG00000074345.5"}]},{"database":"GeneID","id":"244882","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:244882","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009pmt.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2685363","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"388121","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2685363","properties":[{"key":"GeneName","value":"Tnfaip8l3"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000074345","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QRE6","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000003488","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_085918_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3TBL6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RMCEGIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10055976at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q3TBL6","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-1483255","properties":[{"key":"PathwayName","value":"PI Metabolism"}]},{"database":"BioGRID-ORCS","id":"244882","properties":[{"key":"hits","value":"1 hit in 79 CRISPR screens"}]},{"database":"PRO","id":"PR:Q3TBL6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"Q3TBL6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000074345","properties":[{"key":"ExpressionPatterns","value":"Expressed in dentate gyrus of hippocampal formation granule cell and 32 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25479791"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25242044"}]},{"database":"GO","id":"GO:0035091","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25242044"}]},{"database":"GO","id":"GO:0008526","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol transfer activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25242044"}]},{"database":"GO","id":"GO:1902633","properties":[{"key":"GoTerm","value":"P:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25242044"}]},{"database":"GO","id":"GO:0015914","properties":[{"key":"GoTerm","value":"P:phospholipid transport"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25242044"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25242044"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:1902531","properties":[{"key":"GoTerm","value":"P:regulation of intracellular signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"FunFam","id":"1.20.1440.160:FF:000001","properties":[{"key":"EntryName","value":"Tumor necrosis factor alpha-induced protein 8-like 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1440.160","properties":[{"key":"EntryName","value":"Tumor necrosis factor alpha-induced protein 8-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008477","properties":[{"key":"EntryName","value":"TNFAIP8-like"}]},{"database":"InterPro","id":"IPR038355","properties":[{"key":"EntryName","value":"TNFAIP8_sf"}]},{"database":"PANTHER","id":"PTHR12757:SF5","properties":[{"key":"EntryName","value":"TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12757","properties":[{"key":"EntryName","value":"TUMOR NECROSIS FACTOR INDUCED PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05527","properties":[{"key":"EntryName","value":"TNFAIP8"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDSDSGEQSEGEPGTAAGPHVFSSKNLALQAQKKILSKIASKTVANMLIDDTSSEIFDELYKVTEIHTHNKKEAHKIMKDAIKVAIKIGILYRNKQFSQEEVIIVEKLRKKLNQTAMTMVSFYEVEYTFDTNVLSKLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYGPHGNCRPNLKRICEGINKLLDDKIL","length":204,"molWeight":23243,"crc64":"2A5830746A4D8AE5","md5":"1ABCB03BB8120B2D8C485F3F3EA3C2D7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":1,"Mutagenesis":7},"uniParcId":"UPI00001C4486"}}