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Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28436939"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29420262"}],"value":"Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation (PubMed:28436939). Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion (PubMed:28436939). Interacts (via N-terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains) (PubMed:29420262). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin-protein ligase complexes (PubMed:29420262)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q3KP66","intActId":"EBI-7545562"},"interactantTwo":{"uniProtKBAccession":"Q9Y297","geneName":"BTRC","intActId":"EBI-307461"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3KP66","intActId":"EBI-7545562"},"interactantTwo":{"uniProtKBAccession":"Q15438","geneName":"CYTH1","intActId":"EBI-997830"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3KP66","intActId":"EBI-7545562"},"interactantTwo":{"uniProtKBAccession":"Q99418","geneName":"CYTH2","intActId":"EBI-448974"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3KP66","intActId":"EBI-7545562"},"interactantTwo":{"uniProtKBAccession":"Q9UKB1","geneName":"FBXW11","intActId":"EBI-355189"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3KP66-1","intActId":"EBI-52354453"},"interactantTwo":{"uniProtKBAccession":"Q15438","geneName":"CYTH1","intActId":"EBI-997830"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3KP66-1","intActId":"EBI-52354453"},"interactantTwo":{"uniProtKBAccession":"Q99418","geneName":"CYTH2","intActId":"EBI-448974"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28436939"}],"value":"Translocates to the nucleus upon NOD2 stimulation"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28436939"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28436939"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q3KP66-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q3KP66-3"],"sequenceIds":["VSP_046048"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28436939"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29420262"}],"value":"Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28436939"}],"value":"Expression is induced by the component of peptidoglycan muramyl dipeptide (PubMed:28436939). 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