{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3E828","secondaryAccessions":["D6VW58"],"uniProtkbId":"EMR1_YEAST","entryAudit":{"firstPublicDate":"2006-07-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-11-08","entryVersion":91,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"ERMES regulator 1"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"SGD","id":"S000028522"}],"value":"MCO6"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"SGD","id":"S000028522"}],"value":"YJL127C-B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4ZGE1"}],"value":"Mediates the formation of endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) foci, thereby contributing to the formation of ER-mitochondrial contact sites"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26928762"}],"value":"Mitochondrion outer membrane","id":"SL-0172"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4ZGE1"}],"value":"Single-pass type III membrane protein","id":"SL-9907"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the EMR1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"ERMES regulator 1","featureId":"PRO_0000245410"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4ZGE1"}]},{"type":"Transmembrane","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4ZGE1"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1000","category":"Cellular component","name":"Mitochondrion outer membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"8641269","citationType":"journal article","authors":["Galibert F.","Alexandraki D.","Baur A.","Boles E.","Chalwatzis N.","Chuat J.-C.","Coster F.","Cziepluch C.","de Haan M.","Domdey H.","Durand P.","Entian K.-D.","Gatius M.","Goffeau A.","Grivell L.A.","Hennemann A.","Herbert C.J.","Heumann K.","Hilger F.","Hollenberg C.P.","Huang M.-E.","Jacq C.","Jauniaux J.-C.","Katsoulou C.","Kirchrath L.","Kleine K.","Kordes E.","Koetter P.","Liebl S.","Louis E.J.","Manus V.","Mewes H.-W.","Miosga T.","Obermaier B.","Perea J.","Pohl T.M.","Portetelle D.","Pujol A.","Purnelle B.","Ramezani Rad M.","Rasmussen S.W.","Rose M.","Rossau R.","Schaaff-Gerstenschlaeger I.","Smits P.H.M.","Scarcez T.","Soriano N.","To Van D.","Tzermia M.","Van Broekhoven A.","Vandenbol M.","Wedler H.","von Wettstein D.","Wambutt R.","Zagulski M.","Zollner A.","Karpfinger-Hartl L."],"citationCrossReferences":[{"database":"PubMed","id":"8641269"},{"database":"DOI","id":"10.1002/j.1460-2075.1996.tb00557.x"}],"title":"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.","publicationDate":"1996","journal":"EMBO J.","firstPage":"2031","lastPage":"2049","volume":"15"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"12844361","citationType":"journal article","authors":["Brachat S.","Dietrich F.S.","Voegeli S.","Zhang Z.","Stuart L.","Lerch A.","Gates K.","Gaffney T.D.","Philippsen P."],"citationCrossReferences":[{"database":"PubMed","id":"12844361"},{"database":"DOI","id":"10.1186/gb-2003-4-7-r45"}],"title":"Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.","publicationDate":"2003","journal":"Genome Biol.","firstPage":"R45.1","lastPage":"R45.13","volume":"4"},"referencePositions":["GENOME REANNOTATION"]},{"referenceNumber":4,"citation":{"id":"26928762","citationType":"journal article","authors":["Yofe I.","Weill U.","Meurer M.","Chuartzman S.","Zalckvar E.","Goldman O.","Ben-Dor S.","Schuetze C.","Wiedemann N.","Knop M.","Khmelinskii A.","Schuldiner M."],"citationCrossReferences":[{"database":"PubMed","id":"26928762"},{"database":"DOI","id":"10.1038/nmeth.3795"}],"title":"One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.","publicationDate":"2016","journal":"Nat. Methods","firstPage":"371","lastPage":"378","volume":"13"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z49402","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006943","properties":[{"key":"ProteinId","value":"DAA08674.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_878103.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001184532.1"}]},{"database":"AlphaFoldDB","id":"Q3E828","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"37008","properties":[{"key":"Interactions","value":"44"}]},{"database":"FunCoup","id":"Q3E828","properties":[{"key":"Number of interactors","value":"11"}]},{"database":"STRING","id":"4932.YJL127C-B","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YJL127C-B","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q3E828","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YJL127C-B_mRNA","properties":[{"key":"ProteinId","value":"YJL127C-B"},{"key":"GeneId","value":"YJL127C-B"}]},{"database":"GeneID","id":"1466466","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YJL127C-B","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000028522","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000028522","properties":[{"key":"GeneName","value":"MCO6"}]},{"database":"VEuPathDB","id":"FungiDB:YJL127C-B","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SBQD","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_3088968_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3E828","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NIFVESH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2122015at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-31804-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"1466466","properties":[{"key":"hits","value":"1 hit in 10 CRISPR screens"}]},{"database":"PRO","id":"PR:Q3E828","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"Q3E828","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005741","properties":[{"key":"GoTerm","value":"C:mitochondrial outer membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26928762"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"26928762"}]},{"database":"GO","id":"GO:0001401","properties":[{"key":"GoTerm","value":"C:SAM complex"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38377000"}]},{"database":"GO","id":"GO:0070096","properties":[{"key":"GoTerm","value":"P:mitochondrial outer membrane translocase complex assembly"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"38377000"}]},{"database":"InterPro","id":"IPR035195","properties":[{"key":"EntryName","value":"Emr1"}]},{"database":"Pfam","id":"PF17237","properties":[{"key":"EntryName","value":"Emr1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIFFFNQIRSIFTALHTPTQQIQLSRRAFFQFLGYLGSCVVISLAAQSKYVQ","length":52,"molWeight":6017,"crc64":"A1CBFF3B98C8CFAA","md5":"8B706698E1C88F938E3EB960B9E20CC4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":2,"Transmembrane":1},"uniParcId":"UPI00001B65B7"}}