{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3B820","secondaryAccessions":["B4DJV7","Q9H8R2"],"uniProtkbId":"F161A_HUMAN","entryAudit":{"firstPublicDate":"2008-04-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-04-08","entryVersion":147,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein FAM161A"}}},"genes":[{"geneName":{"value":"FAM161A"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22940612"}],"value":"Involved in ciliogenesis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22791751"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22940612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25018096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27588451"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32110738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36233334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37934472"}],"value":"Interacts (via central region) with CFAP418 (via N-terminus); the interaction is direct (PubMed:36233334). Interacts (via C-terminus) with microtubules (PubMed:22791751). Interacts with LCA5 (PubMed:22940612). Interacts with CEP290 (PubMed:22940612). Interacts with SDCCAG8 (PubMed:22940612). Interacts with FAM161B (PubMed:22791751). Interacts with POC1B (PubMed:25018096). Interacts with CEP78 (PubMed:27588451). Forms a microtubule-associated complex with POC5, CETN2 and POC1B (PubMed:32110738). Interacts with CCDC15 (PubMed:37934472)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P29972","geneName":"AQP1","intActId":"EBI-745213"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9Y2T1","geneName":"AXIN2","intActId":"EBI-4400025"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BYV9","geneName":"BACH2","intActId":"EBI-1642333"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BUH8","geneName":"BEGAIN","intActId":"EBI-742722"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q5T5X7","geneName":"BEND3","intActId":"EBI-1211496"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q7L4P6","geneName":"BEND5","intActId":"EBI-724373"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8TD16-2","geneName":"BICD2","intActId":"EBI-11975051"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"A2RRN7","geneName":"CADPS","intActId":"EBI-10179719"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9P1Z2","geneName":"CALCOCO1","intActId":"EBI-749920"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q13137","geneName":"CALCOCO2","intActId":"EBI-739580"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9H257","geneName":"CARD9","intActId":"EBI-751319"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9H257-2","geneName":"CARD9","intActId":"EBI-11530605"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8NA61","geneName":"CBY2","intActId":"EBI-741724"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8NA61-2","geneName":"CBY2","intActId":"EBI-11524851"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q68D86","geneName":"CCDC102B","intActId":"EBI-10171570"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86Z20","geneName":"CCDC125","intActId":"EBI-11977221"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8IYE1","geneName":"CCDC13","intActId":"EBI-10961312"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96JN2-2","geneName":"CCDC136","intActId":"EBI-10171416"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8N715","geneName":"CCDC185","intActId":"EBI-740814"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q2TAC2","geneName":"CCDC57","intActId":"EBI-2808286"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q2TAC2-2","geneName":"CCDC57","intActId":"EBI-10961624"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"A6NC98","geneName":"CCDC88B","intActId":"EBI-347573"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P24863","geneName":"CCNC","intActId":"EBI-395261"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O95273","geneName":"CCNDBP1","intActId":"EBI-748961"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q01850","geneName":"CDR2","intActId":"EBI-1181367"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86X02","geneName":"CDR2L","intActId":"EBI-11063830"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9C0F1","geneName":"CEP44","intActId":"EBI-744115"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8IYX8-2","geneName":"CEP57L1","intActId":"EBI-10181988"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96MT8","geneName":"CEP63","intActId":"EBI-741977"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96MT8-3","geneName":"CEP63","intActId":"EBI-11522539"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8NHQ1","geneName":"CEP70","intActId":"EBI-739624"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9P209","geneName":"CEP72","intActId":"EBI-739498"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96NL8","geneName":"CFAP418","intActId":"EBI-11904873"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9UI47-2","geneName":"CTNNA3","intActId":"EBI-11962928"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q7L7V1","geneName":"DHX32","intActId":"EBI-2807297"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8NF50-2","geneName":"DOCK8","intActId":"EBI-10174653"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"A2ABF9","geneName":"EHMT2","intActId":"EBI-10174566"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O60447","geneName":"EVI5","intActId":"EBI-852291"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q3B820","geneName":"FAM161A","intActId":"EBI-719941"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8IZU0","geneName":"FAM9B","intActId":"EBI-10175124"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"A1L4K1","geneName":"FSD2","intActId":"EBI-5661036"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P51114-2","geneName":"FXR1","intActId":"EBI-11022345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O95995","geneName":"GAS8","intActId":"EBI-1052570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"A6NEM1","geneName":"GOLGA6L9","intActId":"EBI-5916454"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86WP2","geneName":"GPBP1","intActId":"EBI-2349758"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q6PI77","geneName":"GPRASP3","intActId":"EBI-11519926"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q4V328","geneName":"GRIPAP1","intActId":"EBI-717919"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96MH2","geneName":"HEXIM2","intActId":"EBI-5460660"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q6NT76","geneName":"HMBOX1","intActId":"EBI-2549423"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9UJC3","geneName":"HOOK1","intActId":"EBI-746704"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96ED9-2","geneName":"HOOK2","intActId":"EBI-10961706"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q13422","geneName":"IKZF1","intActId":"EBI-745305"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8NBZ0","geneName":"INO80E","intActId":"EBI-769401"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O75564-2","geneName":"JRK","intActId":"EBI-17181882"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q63ZY3","geneName":"KANK2","intActId":"EBI-2556193"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8N6L0","geneName":"KASH5","intActId":"EBI-749265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q92993","geneName":"KAT5","intActId":"EBI-399080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O60341","geneName":"KDM1A","intActId":"EBI-710124"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q2KHM9","geneName":"KIAA0753","intActId":"EBI-2805604"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86T90","geneName":"KIAA1328","intActId":"EBI-3437878"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BVG8-5","geneName":"KIFC3","intActId":"EBI-14069005"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P60409","geneName":"KRTAP10-7","intActId":"EBI-10172290"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P60410","geneName":"KRTAP10-8","intActId":"EBI-10171774"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P60411","geneName":"KRTAP10-9","intActId":"EBI-10172052"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BYR9","geneName":"KRTAP2-4","intActId":"EBI-14065470"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q6L8G8","geneName":"KRTAP5-7","intActId":"EBI-11987425"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P26371","geneName":"KRTAP5-9","intActId":"EBI-3958099"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O95751","geneName":"LDOC1","intActId":"EBI-740738"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P02545","geneName":"LMNA","intActId":"EBI-351935"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8IV03","geneName":"LURAP1L","intActId":"EBI-12898559"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9Y250","geneName":"LZTS1","intActId":"EBI-1216080"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BRK4","geneName":"LZTS2","intActId":"EBI-741037"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P43364","geneName":"MAGEA11","intActId":"EBI-739552"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P23508","geneName":"MCC","intActId":"EBI-307531"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q14566","geneName":"MCM6","intActId":"EBI-374900"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q99750","geneName":"MDFI","intActId":"EBI-724076"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9UJV3-2","geneName":"MID2","intActId":"EBI-10172526"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8TD10","geneName":"MIPOL1","intActId":"EBI-2548751"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9UHC7","geneName":"MKRN1","intActId":"EBI-373524"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O94964-4","geneName":"MTCL2","intActId":"EBI-14083835"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q5JR59","geneName":"MTUS2","intActId":"EBI-742948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q5JR59-3","geneName":"MTUS2","intActId":"EBI-11522433"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q7Z6G3-2","geneName":"NECAB2","intActId":"EBI-10172876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9Y2I6","geneName":"NINL","intActId":"EBI-719716"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86Y26","geneName":"NUTM1","intActId":"EBI-10178410"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9H4L5","geneName":"OSBPL3","intActId":"EBI-1051317"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q5VU43","geneName":"PDE4DIP","intActId":"EBI-1105124"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8TBR0","geneName":"PDE4DIP","intActId":"EBI-10240575"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8IXK0","geneName":"PHC2","intActId":"EBI-713786"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q4G0R1","geneName":"PIBF1","intActId":"EBI-14066006"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9NRD5","geneName":"PICK1","intActId":"EBI-79165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q58EX7","geneName":"PLEKHG4","intActId":"EBI-949255"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8ND90","geneName":"PNMA1","intActId":"EBI-302345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9UL42","geneName":"PNMA2","intActId":"EBI-302355"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8NA72","geneName":"POC5","intActId":"EBI-2561090"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8NA72-3","geneName":"POC5","intActId":"EBI-11751537"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q13136","geneName":"PPFIA1","intActId":"EBI-745426"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q969Q6","geneName":"PPP2R3C","intActId":"EBI-2561661"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P31321","geneName":"PRKAR1B","intActId":"EBI-2805516"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P47897","geneName":"QARS1","intActId":"EBI-347462"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q6NUQ1","geneName":"RINT1","intActId":"EBI-726876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9HAT0","geneName":"ROPN1","intActId":"EBI-1378139"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q92622","geneName":"RUBCN","intActId":"EBI-2952709"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q59EK9","geneName":"RUNDC3A","intActId":"EBI-747225"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BWG6","geneName":"SCNM1","intActId":"EBI-748391"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96GM5","geneName":"SMARCD1","intActId":"EBI-358489"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9Y2D8","geneName":"SSX2IP","intActId":"EBI-2212028"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O75558","geneName":"STX11","intActId":"EBI-714135"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8N0S2","geneName":"SYCE1","intActId":"EBI-6872807"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86VP1","geneName":"TAX1BP1","intActId":"EBI-529518"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86TI0","geneName":"TBC1D1","intActId":"EBI-1644036"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9UBB9","geneName":"TFIP11","intActId":"EBI-1105213"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q15025","geneName":"TNIP1","intActId":"EBI-357849"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96KP6","geneName":"TNIP3","intActId":"EBI-2509913"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q13077","geneName":"TRAF1","intActId":"EBI-359224"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q12933","geneName":"TRAF2","intActId":"EBI-355744"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96RU7","geneName":"TRIB3","intActId":"EBI-492476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9C019","geneName":"TRIM15","intActId":"EBI-2342111"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P14373","geneName":"TRIM27","intActId":"EBI-719493"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O94972","geneName":"TRIM37","intActId":"EBI-741602"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8WV44","geneName":"TRIM41","intActId":"EBI-725997"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BYV2","geneName":"TRIM54","intActId":"EBI-2130429"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q86WT6-2","geneName":"TRIM69","intActId":"EBI-11525489"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8N3L3","geneName":"TXLNB","intActId":"EBI-6116822"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P08670","geneName":"VIM","intActId":"EBI-353844"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8N1B4","geneName":"VPS52","intActId":"EBI-2799833"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9Y2K1","geneName":"ZBTB1","intActId":"EBI-2682961"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O43829","geneName":"ZBTB14","intActId":"EBI-10176632"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O43298","geneName":"ZBTB43","intActId":"EBI-740718"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q96BR9","geneName":"ZBTB8A","intActId":"EBI-742740"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9NZV7","geneName":"ZIM2","intActId":"EBI-11962760"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P17028","geneName":"ZNF24","intActId":"EBI-707773"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"P15622-3","geneName":"ZNF250","intActId":"EBI-10177272"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8N554","geneName":"ZNF276","intActId":"EBI-750821"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9BUY5","geneName":"ZNF426","intActId":"EBI-743265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q8TF50","geneName":"ZNF526","intActId":"EBI-11035148"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q3KQV3","geneName":"ZNF792","intActId":"EBI-10240849"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"Q9UGI0","geneName":"ZRANB1","intActId":"EBI-527853"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3B820","intActId":"EBI-719941"},"interactantTwo":{"uniProtKBAccession":"O43309","geneName":"ZSCAN12","intActId":"EBI-1210440"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32110738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37934472"}],"value":"Localized to the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium. Localizes to the inner scaffold in the central region of centrioles"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22940612"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22940612"}],"value":"Cell projection, cilium","id":"SL-0066"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32110738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32946374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37934472"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole","id":"SL-0046"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q3B820-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q3B820-2"],"sequenceIds":["VSP_032935"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q3B820-3"],"sequenceIds":["VSP_039126"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20705278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20705279"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36233334"}],"value":"Isoform 1 and isoform 3 are widely expressed with highest levels in retina and testis, with isoform 1 being the most abundant in all tissues tested"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Retinitis pigmentosa 28","diseaseAccession":"DI-02911","acronym":"RP28","description":"A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.","diseaseCrossReference":{"database":"MIM","id":"606068"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20705278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20705279"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31236346"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the FAM161 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAG58969.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Protein FAM161A","featureId":"PRO_0000329052"},{"type":"Region","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"Required for interaction with CFAP418","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36233334"}]},{"type":"Region","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":522,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":606,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Cross-link","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_032935","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_039126","alternativeSequence":{"originalSequence":"V","alternativeSequences":["VRRSLEEKKMLEEERNRILTKQKQRMKELQKLLTTRAKAYDSHQSLAQISKSRVKCL"]}},{"type":"Natural variant","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in dbSNP:rs11125895","featureCrossReferences":[{"database":"dbSNP","id":"rs11125895"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17974005"}],"featureId":"VAR_060180","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in dbSNP:rs17513722","featureCrossReferences":[{"database":"dbSNP","id":"rs17513722"}],"featureId":"VAR_042630","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in dbSNP:rs6733774","featureCrossReferences":[{"database":"dbSNP","id":"rs6733774"}],"featureId":"VAR_042631","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"in RP28","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31236346"}],"featureId":"VAR_083934","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in Ref. 1; BX648834","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in Ref. 3; BAB14544","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"in Ref. 3; BAG58969","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["M"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-1186","category":"Disease","name":"Ciliopathy"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0682","category":"Disease","name":"Retinitis pigmentosa"},{"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0844","category":"Biological process","name":"Vision"}],"references":[{"referenceNumber":1,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)","VARIANT MET-107"],"referenceComments":[{"value":"Colon endothelium","type":"TISSUE"},{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-545 (ISOFORM 2)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-660 (ISOFORMS 1/2)"],"referenceComments":[{"value":"Ovary","type":"TISSUE"},{"value":"Thalamus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-660 (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"14654843","citationType":"journal article","authors":["Andersen J.S.","Wilkinson C.J.","Mayor T.","Mortensen P.","Nigg E.A.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"14654843"},{"database":"DOI","id":"10.1038/nature02166"}],"title":"Proteomic characterization of the human centrosome by protein correlation profiling.","publicationDate":"2003","journal":"Nature","firstPage":"570","lastPage":"574","volume":"426"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Lymphoblast","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"20705278","citationType":"journal article","authors":["Langmann T.","Di Gioia S.A.","Rau I.","Stohr H.","Maksimovic N.S.","Corbo J.C.","Renner A.B.","Zrenner E.","Kumaramanickavel G.","Karlstetter M.","Arsenijevic Y.","Weber B.H.","Gal A.","Rivolta C."],"citationCrossReferences":[{"database":"PubMed","id":"20705278"},{"database":"DOI","id":"10.1016/j.ajhg.2010.07.018"}],"title":"Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa.","publicationDate":"2010","journal":"Am. J. Hum. Genet.","firstPage":"376","lastPage":"381","volume":"87"},"referencePositions":["INVOLVEMENT IN RP28","TISSUE SPECIFICITY"]},{"referenceNumber":7,"citation":{"id":"20705279","citationType":"journal article","authors":["Bandah-Rozenfeld D.","Mizrahi-Meissonnier L.","Farhy C.","Obolensky A.","Chowers I.","Pe'er J.","Merin S.","Ben-Yosef T.","Ashery-Padan R.","Banin E.","Sharon D."],"citationCrossReferences":[{"database":"PubMed","id":"20705279"},{"database":"DOI","id":"10.1016/j.ajhg.2010.07.022"}],"title":"Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa.","publicationDate":"2010","journal":"Am. J. Hum. Genet.","firstPage":"382","lastPage":"391","volume":"87"},"referencePositions":["INVOLVEMENT IN RP28","TISSUE SPECIFICITY"]},{"referenceNumber":8,"citation":{"id":"22940612","citationType":"journal article","authors":["Di Gioia S.A.","Letteboer S.J.","Kostic C.","Bandah-Rozenfeld D.","Hetterschijt L.","Sharon D.","Arsenijevic Y.","Roepman R.","Rivolta C."],"citationCrossReferences":[{"database":"PubMed","id":"22940612"},{"database":"DOI","id":"10.1093/hmg/dds368"}],"title":"FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies.","publicationDate":"2012","journal":"Hum. Mol. Genet.","firstPage":"5174","lastPage":"5184","volume":"21"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH LCA5; CEP290 AND SDCCAG8"]},{"referenceNumber":9,"citation":{"id":"22791751","citationType":"journal article","authors":["Zach F.","Grassmann F.","Langmann T.","Sorusch N.","Wolfrum U.","Stohr H."],"citationCrossReferences":[{"database":"PubMed","id":"22791751"},{"database":"DOI","id":"10.1093/hmg/dds268"}],"title":"The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association.","publicationDate":"2012","journal":"Hum. Mol. Genet.","firstPage":"4573","lastPage":"4586","volume":"21"},"referencePositions":["INTERACTION WITH MICROTUBULES AND FAM161B"]},{"referenceNumber":10,"citation":{"id":"25018096","citationType":"journal article","authors":["Roosing S.","Lamers I.J.","de Vrieze E.","van den Born L.I.","Lambertus S.","Arts H.H.","Peters T.A.","Hoyng C.B.","Kremer H.","Hetterschijt L.","Letteboer S.J.","van Wijk E.","Roepman R.","den Hollander A.I.","Cremers F.P.","Boldt K.","de Baere E.","Klaver C.C.","Coppieters F.","Koolen D.A.","Lugtenberg D.","Neveling K.","van Reeuwijk J.","Ueffing M.","van Beersum S.E.","Zonneveld-Vrieling M.N."],"citationCrossReferences":[{"database":"PubMed","id":"25018096"},{"database":"DOI","id":"10.1016/j.ajhg.2014.06.012"}],"title":"Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy.","publicationDate":"2014","journal":"Am. J. Hum. Genet.","firstPage":"131","lastPage":"142","volume":"95"},"referencePositions":["INTERACTION WITH POC1B"]},{"referenceNumber":11,"citation":{"id":"27588451","citationType":"journal article","authors":["Nikopoulos K.","Farinelli P.","Giangreco B.","Tsika C.","Royer-Bertrand B.","Mbefo M.K.","Bedoni N.","Kjellstroem U.","El Zaoui I.","Di Gioia S.A.","Balzano S.","Cisarova K.","Messina A.","Decembrini S.","Plainis S.","Blazaki S.V.","Khan M.I.","Micheal S.","Boldt K.","Ueffing M.","Moulin A.P.","Cremers F.P.","Roepman R.","Arsenijevic Y.","Tsilimbaris M.K.","Andreasson S.","Rivolta C."],"citationCrossReferences":[{"database":"PubMed","id":"27588451"},{"database":"DOI","id":"10.1016/j.ajhg.2016.07.009"}],"title":"Mutations in CEP78 cause cone-rod dystrophy and hearing loss associated with primary-cilia defects.","publicationDate":"2016","journal":"Am. J. Hum. Genet.","firstPage":"770","lastPage":"776","volume":"99"},"referencePositions":["INTERACTION WITH CEP78"]},{"referenceNumber":12,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-468 AND LYS-484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"32110738","citationType":"journal article","authors":["Le Guennec M.","Klena N.","Gambarotto D.","Laporte M.H.","Tassin A.M.","van den Hoek H.","Erdmann P.S.","Schaffer M.","Kovacik L.","Borgers S.","Goldie K.N.","Stahlberg H.","Bornens M.","Azimzadeh J.","Engel B.D.","Hamel V.","Guichard P."],"citationCrossReferences":[{"database":"PubMed","id":"32110738"},{"database":"DOI","id":"10.1126/sciadv.aaz4137"}],"title":"A helical inner scaffold provides a structural basis for centriole cohesion.","publicationDate":"2020","journal":"Sci. Adv.","firstPage":"eaaz4137","lastPage":"eaaz4137","volume":"6"},"referencePositions":["SUBCELLULAR LOCATION","COMPLEX FORMATION WITH POC1B; CETN2 AND POC5"]},{"referenceNumber":14,"citation":{"id":"32946374","citationType":"journal article","authors":["Steib E.","Laporte M.H.","Gambarotto D.","Olieric N.","Zheng C.","Borgers S.","Olieric V.","Le Guennec M.","Koll F.","Tassin A.M.","Steinmetz M.O.","Guichard P.","Hamel V."],"citationCrossReferences":[{"database":"PubMed","id":"32946374"},{"database":"DOI","id":"10.7554/elife.57205"}],"title":"WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.","publicationDate":"2020","journal":"Elife","firstPage":"0","lastPage":"0","volume":"9"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":15,"citation":{"id":"36233334","citationType":"journal article","authors":["Liu Y.","Chen J.","Sager R.","Sasaki E.","Hu H."],"citationCrossReferences":[{"database":"PubMed","id":"36233334"},{"database":"DOI","id":"10.3390/ijms231912033"}],"title":"Interactions between C8orf37 and FAM161A, Two Ciliary Proteins Essential for Photoreceptor Survival.","publicationDate":"2022","journal":"Int. J. Mol. Sci.","firstPage":"12033","lastPage":"12033","volume":"23"},"referencePositions":["INTERACTION WITH CFAP418","TISSUE SPECIFICITY"]},{"referenceNumber":16,"citation":{"id":"37934472","citationType":"journal article","authors":["Arslanhan M.D.","Cengiz-Emek S.","Odabasi E.","Steib E.","Hamel V.","Guichard P.","Firat-Karalar E.N."],"citationCrossReferences":[{"database":"PubMed","id":"37934472"},{"database":"DOI","id":"10.1083/jcb.202305009"}],"title":"CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity.","publicationDate":"2023","journal":"J. Cell Biol.","firstPage":"0","lastPage":"0","volume":"222"},"referencePositions":["INTERACTION WITH CCDC15","SUBCELLULAR LOCATION"]},{"referenceNumber":17,"citation":{"id":"31236346","citationType":"journal article","authors":["Hu Y.S.","Song H.","Li Y.","Xiao Z.Y.","Li T."],"citationCrossReferences":[{"database":"PubMed","id":"31236346"},{"database":"DOI","id":"10.18240/ijo.2019.06.06"}],"title":"Whole-exome sequencing identifies novel mutations in genes responsible for retinitis pigmentosa in 2 nonconsanguineous Chinese families.","publicationDate":"2019","journal":"Int. J. Ophthalmol.","firstPage":"915","lastPage":"923","volume":"12"},"referencePositions":["VARIANT RP28 315-LYS--HIS-660 DEL"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX648834","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX649029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC107081","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK023367","properties":[{"key":"ProteinId","value":"BAB14544.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK296255","properties":[{"key":"ProteinId","value":"BAG58969.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC107162","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC107163","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS42687.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3B820-1"},{"database":"CCDS","id":"CCDS56120.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3B820-3"},{"database":"RefSeq","id":"NP_001188472.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001201543.2"}],"isoformId":"Q3B820-3"},{"database":"RefSeq","id":"NP_115556.2","properties":[{"key":"NucleotideSequenceId","value":"NM_032180.3"}],"isoformId":"Q3B820-1"},{"database":"AlphaFoldDB","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"123909","properties":[{"key":"Interactions","value":"163"}]},{"database":"FunCoup","id":"Q3B820","properties":[{"key":"Number of interactors","value":"378"}]},{"database":"IntAct","id":"Q3B820","properties":[{"key":"Interactions","value":"154"}]},{"database":"MINT","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-FAM161A","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000385158","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q3B820","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FAM161A","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"182705173","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000385158","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"61665","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3B820-1"},{"database":"ProteomicsDB","id":"61666","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3B820-2"},{"database":"ProteomicsDB","id":"61667","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3B820-3"},{"database":"Antibodypedia","id":"30688","properties":[{"key":"antibodies","value":"74 antibodies from 10 providers"}]},{"database":"DNASU","id":"84140","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000404929.6","properties":[{"key":"ProteinId","value":"ENSP00000385158.1"},{"key":"GeneId","value":"ENSG00000170264.14"}],"isoformId":"Q3B820-3"},{"database":"Ensembl","id":"ENST00000405894.3","properties":[{"key":"ProteinId","value":"ENSP00000385893.3"},{"key":"GeneId","value":"ENSG00000170264.14"}],"isoformId":"Q3B820-1"},{"database":"GeneID","id":"84140","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:84140","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000404929.6","properties":[{"key":"ProteinId","value":"ENSP00000385158.1"},{"key":"RefSeqNucleotideId","value":"NM_001201543.2"},{"key":"RefSeqProteinId","value":"NP_001188472.1"}],"isoformId":"Q3B820-3"},{"database":"UCSC","id":"uc002sbm.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q3B820-1"},{"database":"AGR","id":"HGNC:25808","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162386876","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"84140","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"84140","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FAM161A","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"FAM161A","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25808","properties":[{"key":"GeneName","value":"FAM161A"}]},{"database":"HPA","id":"ENSG00000170264","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (retina)"}]},{"database":"MalaCards","id":"FAM161A","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"606068","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"613596","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000170264","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"791","properties":[{"key":"Disease","value":"Retinitis pigmentosa"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000170264","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QRC3","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157824","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_010955_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EVTECQR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2150121at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q3B820","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000170264","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"84140","properties":[{"key":"hits","value":"14 hits in 1155 CRISPR screens"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"ChiTaRS","id":"FAM161A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"84140","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q3B820","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q3B820","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q3B820","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000170264","properties":[{"key":"ExpressionPatterns","value":"Expressed in pigmented layer of retina and 146 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q3B820","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000235","properties":[{"key":"GoTerm","value":"C:astral microtubule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0005814","properties":[{"key":"GoTerm","value":"C:centriole"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32110738"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37934472"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21399614"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22940612"}]},{"database":"GO","id":"GO:0072686","properties":[{"key":"GoTerm","value":"C:mitotic spindle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0097431","properties":[{"key":"GoTerm","value":"C:mitotic spindle pole"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0032391","properties":[{"key":"GoTerm","value":"C:photoreceptor connecting cilium"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22940612"}]},{"database":"GO","id":"GO:0001917","properties":[{"key":"GoTerm","value":"C:photoreceptor inner segment"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0005876","properties":[{"key":"GoTerm","value":"C:spindle microtubule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22791751"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22940612"}]},{"database":"GO","id":"GO:0044782","properties":[{"key":"GoTerm","value":"P:cilium organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR051655","properties":[{"key":"EntryName","value":"FAM161"}]},{"database":"InterPro","id":"IPR019579","properties":[{"key":"EntryName","value":"FAM161A/B"}]},{"database":"PANTHER","id":"PTHR21501","properties":[{"key":"EntryName","value":"PROTEIN FAM-161"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21501:SF3","properties":[{"key":"EntryName","value":"PROTEIN FAM161A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10595","properties":[{"key":"EntryName","value":"FAM161A_B"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGASADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLVKQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKCKHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRKSEKERMREYQRELEEREEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQETKSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH","length":660,"molWeight":76752,"crc64":"E2C0D443C1A0DAA5","md5":"524E867DF25B669D209A9455C87F0BF5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":141,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":2,"Coiled coil":3,"Compositional bias":2,"Cross-link":2,"Alternative sequence":2,"Natural variant":4,"Sequence conflict":3},"uniParcId":"UPI0000160B77"}}