{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q2WGJ8","uniProtkbId":"CTSRQ_HUMAN","entryAudit":{"firstPublicDate":"2008-04-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-01-10","entryVersion":111,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cation channel sperm-associated auxiliary subunit theta"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cation channel sperm-associated auxiliary subunit TMEM249"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:44155"}],"value":"Catsper channel auxiliary subunit theta"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:44155"}],"value":"Transmembrane protein 249"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:44155"}],"value":"CATSPERQ"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:44155"}],"value":"C8orfK29"},{"value":"TMEM249"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}],"value":"Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZR5"}],"value":"Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, CATSPERT, CATSPERQ, CATSPERH and EFCAB9 (By similarity). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (By similarity). The auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively (By similarity). CATSPERH interacts with CATSPERB, further stabilizing the complex. CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}],"value":"Predominantly located in the principal piece of the sperm tail"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}],"value":"Cell projection, cilium, flagellum membrane","id":"SL-0115"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"In mouse, Slco6c1 is an additional auxiliary subunit of the CatSper complex. It is unclear if the related SLCO6A1 protein performs the same role in non-rodent species"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Cation channel sperm-associated auxiliary subunit theta","featureId":"PRO_0000332223"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}]},{"type":"Transmembrane","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}]},{"type":"Topological domain","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}]},{"type":"Transmembrane","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}]},{"type":"Topological domain","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A2R8VHF7"}]},{"type":"Region","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0282","category":"Cellular component","name":"Flagellum"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-67HCHLIT61AGL","citationType":"submission","authors":["Shimizu N.","Asakawa S.","Shimizu A.","Yamazaki S.","Ishikawa S.K."],"title":"Novel gene on human chromosome 8.","publicationDate":"DEC-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L. 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