{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q2TXG3","uniProtkbId":"ORYB_ASPOR","entryAudit":{"firstPublicDate":"2020-08-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-01-24","entryVersion":112,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Aspergillus oryzae (strain ATCC 42149 / RIB 40)","commonName":"Yellow koji mold","taxonId":510516,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Eurotiomycetes","Eurotiomycetidae","Eurotiales","Aspergillaceae","Aspergillus","Circumdati"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30104550"}],"value":"Fatty acid synthase subunit beta"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30104550"}],"value":"2.3.1.86"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"S-acyl fatty acid synthase thioesterase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"3.1.2.14"}]}],"includes":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"4.2.1.59"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"Enoyl-[acyl-carrier-protein] reductase [NADH]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"1.3.1.9"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"[Acyl-carrier-protein] acetyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"2.3.1.38"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"[Acyl-carrier-protein] malonyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}],"value":"2.3.1.39"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30104550"}],"value":"Oryzines biosynthesis cluster protein oryfasB"}}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30104550"}],"value":"oryfasB"},"orfNames":[{"value":"AO090010000156"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30104550"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30104550"}],"value":"Fatty acid synthase beta subunit; part of the gene cluster that mediates the biosynthesis of oryzines, natural products with an unusual maleidride backbone (PubMed:30104550). The two subunits of the fungal fatty acid synthase oryfasA and oryfasB probably form octenoic acid (Probable). This fatty acid is most likely activated by the acyl-CoA ligase oryP to give octenyl-CoA before the citrate synthase-like protein oryE catalyzes condensation with oxaloacetate to form tricarboxylic acid (Probable). The next steps of the pathways are conjectural, but a favorite possible route has been proposed, beginning with decarboxylation and concomitant dehydration by the decarboxylase oryM, followed by tautomerization, which may lead to the production of a diene intermediate (Probable). Reduction of this diene intermediate could give the known metabolite piliformic acid (Probable). On the pathway to oryzine B and oryzine A, however, hydroxylation of the diene by the alpha-ketoglutarate-dependent dioxygenase oryG and lactonization by the lactonohydrolases oryH or oryL could give oryzine B directly (Probable). Finally, enoyl reduction by the dehydrogenase oryD would then convert oryzine B into oryzine A (Probable)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).","ecNumber":"2.3.1.86","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41788"},{"database":"Rhea","id":"RHEA-COMP:9621"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78446"}],"ecNumber":"2.3.1.38","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41792"},{"database":"Rhea","id":"RHEA-COMP:9623"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57384"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78449"}],"ecNumber":"2.3.1.39","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13097"},{"database":"Rhea","id":"RHEA-COMP:9925"},{"database":"Rhea","id":"RHEA-COMP:9945"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:78784"},{"database":"ChEBI","id":"CHEBI:78827"}],"ecNumber":"4.2.1.59","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10240"},{"database":"Rhea","id":"RHEA-COMP:9925"},{"database":"Rhea","id":"RHEA-COMP:9926"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78784"},{"database":"ChEBI","id":"CHEBI:78785"}],"ecNumber":"1.3.1.9","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15057"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"Rhea","id":"RHEA-COMP:9924"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78783"}],"ecNumber":"3.1.2.14","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TGA1"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30104550"}],"value":"Secondary metabolite biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19097"}],"value":"[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the fungal fatty acid synthetase subunit beta family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2026,"modifier":"EXACT"}},"description":"Fatty acid synthase subunit beta","featureId":"PRO_0000450484"},{"type":"Domain","location":{"start":{"value":1512,"modifier":"EXACT"},"end":{"value":1625,"modifier":"EXACT"}},"description":"MaoC-like","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"Acetyltransferase (AT) domain","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"Enoyl reductase (ER) domain","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1130,"modifier":"EXACT"},"end":{"value":1604,"modifier":"EXACT"}},"description":"Dehydratase (DH) domain","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1643,"modifier":"EXACT"},"end":{"value":2016,"modifier":"EXACT"}},"description":"Malonyl/palmitoyl transferase (MT/PT) domain","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Active site","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PIRSR","id":"PIRSR005562-1"}]},{"type":"Active site","location":{"start":{"value":1788,"modifier":"EXACT"},"end":{"value":1788,"modifier":"EXACT"}},"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PIRSR","id":"PIRSR005562-1"}]}],"keywords":[{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"id":"KW-0520","category":"Ligand","name":"NAD"},{"id":"KW-0521","category":"Ligand","name":"NADP"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"16372010","citationType":"journal article","authors":["Machida M.","Asai K.","Sano M.","Tanaka T.","Kumagai T.","Terai G.","Kusumoto K.","Arima T.","Akita O.","Kashiwagi Y.","Abe K.","Gomi K.","Horiuchi H.","Kitamoto K.","Kobayashi T.","Takeuchi M.","Denning D.W.","Galagan J.E.","Nierman W.C.","Yu J.","Archer D.B.","Bennett J.W.","Bhatnagar D.","Cleveland T.E.","Fedorova N.D.","Gotoh O.","Horikawa H.","Hosoyama A.","Ichinomiya M.","Igarashi R.","Iwashita K.","Juvvadi P.R.","Kato M.","Kato Y.","Kin T.","Kokubun A.","Maeda H.","Maeyama N.","Maruyama J.","Nagasaki H.","Nakajima T.","Oda K.","Okada K.","Paulsen I.","Sakamoto K.","Sawano T.","Takahashi M.","Takase K.","Terabayashi Y.","Wortman J.R.","Yamada O.","Yamagata Y.","Anazawa H.","Hata Y.","Koide Y.","Komori T.","Koyama Y.","Minetoki T.","Suharnan S.","Tanaka A.","Isono K.","Kuhara S.","Ogasawara N.","Kikuchi H."],"citationCrossReferences":[{"database":"PubMed","id":"16372010"},{"database":"DOI","id":"10.1038/nature04300"}],"title":"Genome sequencing and analysis of Aspergillus oryzae.","publicationDate":"2005","journal":"Nature","firstPage":"1157","lastPage":"1161","volume":"438"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 42149 / RIB 40","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"30104550","citationType":"journal article","authors":["Wasil Z.","Kuhnert E.","Simpson T.J.","Cox R.J."],"citationCrossReferences":[{"database":"PubMed","id":"30104550"},{"database":"DOI","id":"10.3390/jof4030096"}],"title":"Oryzines A & B, maleidride congeners from Aspergillus oryzae and their putative biosynthesis.","publicationDate":"2018","journal":"J. Fungi","firstPage":"0","lastPage":"0","volume":"4"},"referencePositions":["FUNCTION","PATHWAY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BA000056","properties":[{"key":"ProteinId","value":"BAE66060.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_001827193.1","properties":[{"key":"NucleotideSequenceId","value":"XM_001827141.1"}]},{"database":"AlphaFoldDB","id":"Q2TXG3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q2TXG3","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"510516.Q2TXG3","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"BAE66060","properties":[{"key":"ProteinId","value":"BAE66060"},{"key":"GeneId","value":"AO090010000156"}]},{"database":"GeneID","id":"5999327","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"aor:AO090010000156","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AO090010000156","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000114_5_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CAGHVRN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"57876at5052","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006564","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"GO","id":"GO:0005835","properties":[{"key":"GoTerm","value":"C:fatty acid synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019171","properties":[{"key":"GoTerm","value":"F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004313","properties":[{"key":"GoTerm","value":"F:[acyl-carrier-protein] S-acetyltransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004314","properties":[{"key":"GoTerm","value":"F:[acyl-carrier-protein] S-malonyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004318","properties":[{"key":"GoTerm","value":"F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004312","properties":[{"key":"GoTerm","value":"F:fatty acid synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016297","properties":[{"key":"GoTerm","value":"F:fatty acyl-[ACP] hydrolase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004321","properties":[{"key":"GoTerm","value":"F:fatty-acyl-CoA synthase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0044550","properties":[{"key":"GoTerm","value":"P:secondary metabolite biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd03447","properties":[{"key":"EntryName","value":"FAS_MaoC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.930.70:FF:000001","properties":[{"key":"EntryName","value":"Fatty acid synthase beta subunit dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.70:FF:000078","properties":[{"key":"EntryName","value":"Fatty acid synthase beta subunit dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1050.120","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.930.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.128.700","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1120.100","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.3330","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.60.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.20.240.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.129.10","properties":[{"key":"EntryName","value":"Hotdog Thioesterase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.366.10","properties":[{"key":"EntryName","value":"Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR001227","properties":[{"key":"EntryName","value":"Ac_transferase_dom_sf"}]},{"database":"InterPro","id":"IPR014043","properties":[{"key":"EntryName","value":"Acyl_transferase_dom"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR039569","properties":[{"key":"EntryName","value":"FAS1-like_DH_region"}]},{"database":"InterPro","id":"IPR016452","properties":[{"key":"EntryName","value":"Fas1/AflB-like"}]},{"database":"InterPro","id":"IPR013565","properties":[{"key":"EntryName","value":"Fas1/AflB-like_central"}]},{"database":"InterPro","id":"IPR040883","properties":[{"key":"EntryName","value":"FAS_meander"}]},{"database":"InterPro","id":"IPR003965","properties":[{"key":"EntryName","value":"Fatty_acid_synthase"}]},{"database":"InterPro","id":"IPR050830","properties":[{"key":"EntryName","value":"Fungal_FAS"}]},{"database":"InterPro","id":"IPR029069","properties":[{"key":"EntryName","value":"HotDog_dom_sf"}]},{"database":"InterPro","id":"IPR002539","properties":[{"key":"EntryName","value":"MaoC-like_dom"}]},{"database":"InterPro","id":"IPR032088","properties":[{"key":"EntryName","value":"SAT"}]},{"database":"PANTHER","id":"PTHR10982:SF21","properties":[{"key":"EntryName","value":"FATTY ACID SYNTHASE SUBUNIT BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10982","properties":[{"key":"EntryName","value":"MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00698","properties":[{"key":"EntryName","value":"Acyl_transf_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08354","properties":[{"key":"EntryName","value":"Fas1-AflB-like_hel"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13452","properties":[{"key":"EntryName","value":"FAS1_DH_region"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22235","properties":[{"key":"EntryName","value":"FAS1_thioest_ins"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17951","properties":[{"key":"EntryName","value":"FAS_meander"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01575","properties":[{"key":"EntryName","value":"MaoC_dehydratas"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16073","properties":[{"key":"EntryName","value":"SAT"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF005562","properties":[{"key":"EntryName","value":"FAS_yeast_beta"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01483","properties":[{"key":"EntryName","value":"FASYNTHASE"}]},{"database":"SMART","id":"SM00827","properties":[{"key":"EntryName","value":"PKS_AT"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF51395","properties":[{"key":"EntryName","value":"FMN-linked oxidoreductases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54637","properties":[{"key":"EntryName","value":"Thioesterase/thiol ester dehydrase-isomerase"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MASTPSSGSYDLAIVTPTEDHSLRSFSLSQGNVQQTFLVSTQDGAFLDQQKASFLQSYSKDQSILGLVFEFLQFLLDEACPPAPLGAFLGAIESQCVRDANIHDLIVSEPEAKNIIRTYYRAHAVAGLNPRPAPSGLFSTVNIEAHRILMAFGGQGSTNLVCVDELADLYSLYQPLLEPLIASVAPALASLSREPSTLQHYLGREIDLYSWLTIPESRPDRAFTATAAVSFPIIGLLDMAHYYVLGKLLDSDSPKRLRSALQGLTGHSQGIIVAAAVAQADTWASFLAQAQWAIRLLFWMGYECHTAAPASPLSSAAIRDSIEHGEGSPSWLLSVRGLRSPALDALITDCNRRLPESEHLSIGLINTERNIVVAGSPRSLRGLCLRLREIEADDGQDQSRVPFRQRKPVVHHTFLPVSAPFHSSHLRAAADRVKERFPDASSPQVGDLLTAVYHTRTGQDMREMFSPSNNLIHSLVEAVACETVDWPATLQVSRSKPPSHIVLLSSSRLSDLVSEIVDGRGVRIIAGTVLAPTDPAVLGGKAELLTTKPSQAPTPWAELFKARLVAGPDGRPILETRLSQLLQAPPIITAGMTPTTVHWDFVAAVMQAGYHVELAGGGYFDAAGMTTAIEKLAAHVPPGRGITCNLIYASPHSIAFQIPLIRSMIQRGIPIDGLTIGAGVPSQDVVNEWIQTLGIKHLSLKPGSIAAIYEVIEIAKKHPTFPIILQWTGGRGGGHHSCEDFHEPLLQTYRDIRRCSNLYLVVGSGFGQADQMHPYITGEWSLSFGRPVMPCDGILIGSRMMVAREAHTSPQAKELILAAAGVADSEWEQSFKKPTGGVLTVQSEMGQPIHKLATRGVRLWHEMDKTIFSLPRDKRVAALNARKAEIIRRLSADFAKPWFGYNAAGDAVDLEDMTYTEVIARLIRLVYVSHQHRWIDPSYRQLVLDFTYRTLERVSNADYATDKLDLSQPEQFVEQVQQLCPAATTRRLHPDDVRFFLTICKQRGRKPVNFIPALDEDFEYWFKKDSLWQSEDVDSIIDQDADRVCILQGPVAVQYSRRADQSAREILDEIHHGLANHFEEGPSQSDRPSLAISEMVSARVTVTESNTHRIIRPTSESLPSVEDWQAFLASQVTGSVRSAIMAEEVLRGSQRQANPLRRVLEPRTGQSIQIPLDGRDLRLVEDAKNRPLVHIKPSGDQEVAVDFYYYDFVETPGNLRFTYKFDSKSLSLVENLDGRDDRVKLFYAHLWLGRADLSYHRLSEVFEGEEITLSSDLHRHLHNALRHTVPDATASATTNTLPLEAAIIAAWKPLMEPLFVAELQGDLLRLVHLSNSIRYTPGAAPLEVNDVVATKSQVRAVTIKETGKTISVEAQIFRSKTLVATVTSEFFIKGSFSDYETTFSHQDEAAIELKVQSAIDEALLRDREWFLLDDPTQSLIDKTLVFRLHTVTRWKDQSTFTSLKTTGSIYTKHWNGTEQKVGTVASEVVECHGNPVIDFLQRKGTVVQEKVPLKHPGLIDNGSRTIRLPLDNALYSSVSKDYNPIHTSSVFARFADLPGTITHGMYTAAVSRAVTECLAADGETGRLRSFSASFVGMVLPGDQLTVRIRHEAMCHGRMVLSVAAYREGTDEKVLQGEAEVEQRTSAYLFTGQGSQAQNMGMQLYDSSAVARSVWDEVDRRLLDQYGWSILNVVRANPKQITIHFRGARGRRIRDNYLAMRTETRMPDGSTRLEPILRDLTAKSESYTFFDSRGLLYATQFAQPAILLMEKAAFEDMKANGLIQEGAAFAGHSLGEYGVLASLVDFLPFEMMMSVVFYRGLVMQFTMERDSNGHTGFSMVAVSPKRVGKYFDEAMLRIVVDLIHRQSGKLLEIVNFNVEAEQYVCAGHVRNIYILSGILDLLSRSATGPQLVASLRSASDPAITDVAKEIAVYLEKAPQLNNPTELKRGRATIPLQGIDVPFHSSHLRSGVSVYRRFLEERIQAENVQVDRLVGKFIPNVMGKPFAIDRSYLEEAAAVTGSSVLRELALAA","length":2026,"molWeight":224257,"crc64":"3E3CB598EDAD7E4D","md5":"44180549E6CDAF17CF3DD848EE180549"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":6,"PATHWAY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":4,"Active site":2},"uniParcId":"UPI000067887C"}}