{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q2TAL8","secondaryAccessions":["Q4G0F7","Q7L621","Q8TEA5"],"uniProtkbId":"QRIC1_HUMAN","entryAudit":{"firstPublicDate":"2007-01-09","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-01-24","entryVersion":145,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Transcriptional regulator QRICH1"}},"alternativeNames":[{"fullName":{"value":"Glutamine-rich protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"33384352"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:24713"}],"value":"QRICH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30281152"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33384352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40355839"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40608935"}],"value":"Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352, PubMed:40355839). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression (PubMed:40608935). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (PubMed:40608935). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40608935"}],"value":"Component of the zincore complex, a heterotetramer composed of a dimer of QRICH1 and 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translational level via an alternative ribosome re-initiation mechanism in response to various stress such as endoplasmic reticulum stress or oxidative stress (PubMed:33384352). In the absence of stress, ribosomes re-initiate translation at an inhibitory upstream open reading frames (uORFs) of the QRICH1 transcript, which preclude QRICH1 translation. In response to stress and subsequent EIF2S1/eIF-2-alpha phosphorylation, ribosomes bypass the inhibitory uORFs and re-initiate translation at the QRICH1 coding sequence (PubMed:33384352). Positive autoregulation at the transcriptional level (PubMed:33384352)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"33384352"}],"value":"The CARD domain may be involved in the regulation of caspase activity in the context of programmed cell death"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Ververi-Brady syndrome 1","diseaseAccession":"DI-05250","acronym":"VERBRAS1","description":"An autosomal dominant disorder characterized by mild developmental delay and intellectual disability, speech delay, learning difficulties, autistic features, and mild facial 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