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Part of a bifunctional DHAP-shunt salvage pathway for SAM by-products (PubMed:31950558)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11852"},{"database":"ChEBI","id":"CHEBI:16708"},{"database":"ChEBI","id":"CHEBI:17509"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58533"}],"ecNumber":"2.4.2.28","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23042035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31950558"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11853"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31950558"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24869"},{"database":"ChEBI","id":"CHEBI:16708"},{"database":"ChEBI","id":"CHEBI:17319"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58749"}],"ecNumber":"2.4.2.28","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31950558"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:24870"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31950558"}]}]},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":14.0,"unit":"uM","substrate":"5'-methylthioadenosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23042035"}]},{"constant":40.0,"unit":"uM","substrate":"5'-deoxyadenosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23042035"}]},{"constant":41.0,"unit":"uM","substrate":"adenine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31950558"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23042035"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31950558"}],"value":"kcat is 4.5 sec(-1) with 5'-methylthioadenosine as substrate. kcat is 6.7 sec(-1) with 5'-deoxyadenosine as substrate (PubMed:23042035). kcat is 0.06 sec(-1) with adenine as substrate (PubMed:31950558)."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01963"}],"value":"Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01963"}],"value":"Homohexamer. 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