{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q2MV57","secondaryAccessions":["Q6PDZ5","Q8C0B3","Q9CXF5"],"uniProtkbId":"TECT2_MOUSE","entryAudit":{"firstPublicDate":"2006-04-04","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2006-04-04","entryVersion":119,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tectonic-2"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"Tctn2"},"synonyms":[{"value":"Tect2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21725307"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22179047"}],"value":"Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21725307"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22179047"}],"value":"Part of the tectonic-like complex (also named B9 complex)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localizes at the transition zone, a region between the basal body and the ciliary axoneme"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21725307"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q2MV57-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q2MV57-2"],"sequenceIds":["VSP_017766"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21462283"}],"value":"Significant expression is observed in brain, kidney and eye"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21462283"}],"value":"At 8.5 dpc, expressed in the neural tube, most notably in the rhombomere of the future hindbrain. By 10.5 dpc, expressed throughout the brain, the length of the neural tube, the growing edge of the limb buds, heart, and eyes. Strong expression is observed in the kidney at 14.5 dpc"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21565611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21725307"}],"value":"Mice have ventricular septal defects and can display right-sided stomach. The embryos exhibit microphthalmia, cleft palate and polydactyly. Embryos lack also nodal cilia. Cilia in neural tubes are scarce and morphologically defective, and failed to elongate axonemes. Basal bodies dock to the plasma membrane in Tctn2 null neural epithelium. No Arl13b ciliary staining in defective Tctn2 embryos perineural mesenchyme suggesting that, as in Tctn1 null mutants, defective Tctn2 cilia lack Arl13b. Tctn1 and Tctn2 share a common function, with both affecting ciliogenesis in a tissue-specific manner"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the tectonic family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"Tectonic-2","featureId":"PRO_0000229799"},{"type":"Topological domain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":700,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19349973"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_017766","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in Ref. 1; ABB90561","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"in Ref. 1; ABB90561","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"in Ref. 1; ABB90561","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in Ref. 2; BAC27569","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16357211","citationType":"journal article","authors":["Reiter J.F.","Skarnes W.C."],"citationCrossReferences":[{"database":"PubMed","id":"16357211"},{"database":"DOI","id":"10.1101/gad.1363606"}],"title":"Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.","publicationDate":"2006","journal":"Genes Dev.","firstPage":"22","lastPage":"27","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Liver","type":"TISSUE"},{"value":"Medulla oblongata","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"19349973","citationType":"journal article","authors":["Wollscheid B.","Bausch-Fluck D.","Henderson C.","O'Brien R.","Bibel M.","Schiess R.","Aebersold R.","Watts J.D."],"citationCrossReferences":[{"database":"PubMed","id":"19349973"},{"database":"DOI","id":"10.1038/nbt.1532"}],"title":"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.","publicationDate":"2009","journal":"Nat. Biotechnol.","firstPage":"378","lastPage":"386","volume":"27"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-389"]},{"referenceNumber":5,"citation":{"id":"21565611","citationType":"journal article","authors":["Sang L.","Miller J.J.","Corbit K.C.","Giles R.H.","Brauer M.J.","Otto E.A.","Baye L.M.","Wen X.","Scales S.J.","Kwong M.","Huntzicker E.G.","Sfakianos M.K.","Sandoval W.","Bazan J.F.","Kulkarni P.","Garcia-Gonzalo F.R.","Seol A.D.","O'Toole J.F.","Held S.","Reutter H.M.","Lane W.S.","Rafiq M.A.","Noor A.","Ansar M.","Devi A.R.","Sheffield V.C.","Slusarski D.C.","Vincent J.B.","Doherty D.A.","Hildebrandt F.","Reiter J.F.","Jackson P.K."],"citationCrossReferences":[{"database":"PubMed","id":"21565611"},{"database":"DOI","id":"10.1016/j.cell.2011.04.019"}],"title":"Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.","publicationDate":"2011","journal":"Cell","firstPage":"513","lastPage":"528","volume":"145"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","INTERACTION WITH MKS1"]},{"referenceNumber":6,"citation":{"id":"21462283","citationType":"journal article","authors":["Shaheen R.","Faqeih E.","Seidahmed M.Z.","Sunker A.","Alali F.E.","Alkuraya F.S."],"citationCrossReferences":[{"database":"PubMed","id":"21462283"},{"database":"DOI","id":"10.1002/humu.21507"}],"title":"A TCTN2 mutation defines a novel Meckel Gruber syndrome locus.","publicationDate":"2011","journal":"Hum. Mutat.","firstPage":"573","lastPage":"578","volume":"32"},"referencePositions":["TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]},{"referenceNumber":7,"citation":{"id":"22179047","citationType":"journal article","authors":["Chih B.","Liu P.","Chinn Y.","Chalouni C.","Komuves L.G.","Hass P.E.","Sandoval W.","Peterson A.S."],"citationCrossReferences":[{"database":"PubMed","id":"22179047"},{"database":"DOI","id":"10.1038/ncb2410"}],"title":"A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.","publicationDate":"2012","journal":"Nat. Cell Biol.","firstPage":"61","lastPage":"72","volume":"14"},"referencePositions":["IDENTIFICATION IN THE TECTONIC-LIKE COMPLEX","FUNCTION"]},{"referenceNumber":8,"citation":{"id":"21725307","citationType":"journal article","authors":["Garcia-Gonzalo F.R.","Corbit K.C.","Sirerol-Piquer M.S.","Ramaswami G.","Otto E.A.","Noriega T.R.","Seol A.D.","Robinson J.F.","Bennett C.L.","Josifova D.J.","Garcia-Verdugo J.M.","Katsanis N.","Hildebrandt F.","Reiter J.F."],"citationCrossReferences":[{"database":"PubMed","id":"21725307"},{"database":"DOI","id":"10.1038/ng.891"}],"title":"A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.","publicationDate":"2011","journal":"Nat. Genet.","firstPage":"776","lastPage":"784","volume":"43"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","SUBCELLULAR LOCATION","IDENTIFICATION IN THE TECTONIC-LIKE COMPLEX"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ278869","properties":[{"key":"ProteinId","value":"ABB90561.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK014476","properties":[{"key":"ProteinId","value":"BAB29379.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK031829","properties":[{"key":"ProteinId","value":"BAC27569.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC058375","properties":[{"key":"ProteinId","value":"AAH58375.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_080762.1","properties":[{"key":"NucleotideSequenceId","value":"NM_026486.3"}],"isoformId":"Q2MV57-1"},{"database":"AlphaFoldDB","id":"Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"212577","properties":[{"key":"Interactions","value":"1"}]},{"database":"CORUM","id":"Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q2MV57","properties":[{"key":"Number of interactors","value":"311"}]},{"database":"IntAct","id":"Q2MV57","properties":[{"key":"Interactions","value":"3"}]},{"database":"STRING","id":"10090.ENSMUSP00000158959","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q2MV57","properties":[{"key":"glycosylation","value":"5 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q2MV57","properties":[{"key":"glycosylation","value":"9 sites, 3 N-linked glycans (5 sites)"}]},{"database":"iPTMnet","id":"Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000158959","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"263154","properties":[{"key":"Description","value":"-"}],"isoformId":"Q2MV57-1"},{"database":"ProteomicsDB","id":"263155","properties":[{"key":"Description","value":"-"}],"isoformId":"Q2MV57-2"},{"database":"Antibodypedia","id":"45731","properties":[{"key":"antibodies","value":"164 antibodies from 30 providers"}]},{"database":"DNASU","id":"67978","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000239501.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000159383.2"},{"key":"GeneId","value":"ENSMUSG00000118662.2"}],"isoformId":"Q2MV57-1"},{"database":"GeneID","id":"67978","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:67978","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008zqg.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q2MV57-1"},{"database":"AGR","id":"MGI:1915228","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79867","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1915228","properties":[{"key":"GeneName","value":"Tctn2"}]},{"database":"GeneTree","id":"ENSGT00570000079101","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GWFPFLC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9282501at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-5620912","properties":[{"key":"PathwayName","value":"Anchoring of the basal body to the plasma membrane"}]},{"database":"BioGRID-ORCS","id":"67978","properties":[{"key":"hits","value":"2 hits in 22 CRISPR screens"}]},{"database":"PRO","id":"PR:Q2MV57","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q2MV57","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0035869","properties":[{"key":"GoTerm","value":"C:ciliary transition zone"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29487109"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0036038","properties":[{"key":"GoTerm","value":"C:MKS complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21725307"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22179047"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21565611"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21725307"}]},{"database":"GO","id":"GO:1904491","properties":[{"key":"GoTerm","value":"P:protein localization to ciliary transition zone"},{"key":"GoEvidenceType","value":"IMP:WormBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26982032"}]},{"database":"GO","id":"GO:0007224","properties":[{"key":"GoTerm","value":"P:smoothened signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21565611"}]},{"database":"InterPro","id":"IPR040354","properties":[{"key":"EntryName","value":"TCTN1-3"}]},{"database":"InterPro","id":"IPR011677","properties":[{"key":"EntryName","value":"TCTN1-3_dom"}]},{"database":"InterPro","id":"IPR057724","properties":[{"key":"EntryName","value":"TCTN1-3_N"}]},{"database":"PANTHER","id":"PTHR14611","properties":[{"key":"EntryName","value":"TECTONIC FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14611:SF6","properties":[{"key":"EntryName","value":"TECTONIC-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25752","properties":[{"key":"EntryName","value":"DUF1619_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07773","properties":[{"key":"EntryName","value":"TCTN_DUF1619"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGSLSPLSLLWGLLLLQGVLRPLRGDPVFIPPFIRMSSPEVRATLVGGSEDVAVSLSLLQVEEGVLPVPTCGGRRNETVDWNVTVSPRESTLEVTIRWKRGLDWCSADETASFSEPPCVLQMLLVSASHNASCLAHLLIQVEIYPNTSVTHNASENMTVIPNQVYQPLGPCPCDLTAKACDIQCCCDQDCQPEVRELFAQSCFSGVFGGHVSPPSHHHCAVSTTHQTPDWFPLLCVQSPPSTSPFLGHFYHGATSPRHSPGFEAHLHFDLRDFADASYKQGDPIMTTEGYFTIPQVSLAGQCLQDAPVAFLRNFDSVCTMDLEVHQGRDEIVLENMKIRTTGGPVTPTVTYEEAIDLDKFITSPDTVLSVGSAPRNVNVEEHYVFRWQNNSISGLDITVIRAEISAQQRGMMTQRFTVKFLSHHSGGEKEFSGNPGYQLGKPVRALHTAGMNVSTLHLWQPAGRGLCTAAALRPILFGENAFSGCLLEVGIKENCTQLRENVLQRLDLLTQATHVARRGNSDYSDLSDGWLEIIRAEAPDTGADLPLSSVNGVCPEVPARLSIRILTAEAGSVEGVAQREILAVETRFSTVTWQYQCGLTCEDKADLLPLSASVEFINVPAQMPHPPTRFQINFTEYDCTRNELCWPQLLYPLTQYYQGEPQSQCVAKGLMLLSLLMLAILLRHPWVRMCKARDSAAIYH","length":700,"molWeight":77111,"crc64":"59B1C3A973EFD581","md5":"E92F8762099109B0D5F9D9B3727B1EF5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Glycosylation":5,"Alternative sequence":1,"Sequence conflict":4},"uniParcId":"UPI00000231B7"}}