{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q21827","uniProtkbId":"GPTC1_CAEEL","entryAudit":{"firstPublicDate":"2007-05-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":133,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Caenorhabditis elegans","taxonId":6239,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Rhabditina","Rhabditomorpha","Rhabditoidea","Rhabditidae","Peloderinae","Caenorhabditis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"R07E5.1"}],"value":"G patch domain-containing protein 1 homolog"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"R07E5.1"}],"value":"gpch-1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"R07E5.1"}],"value":"R07E5.1"}]}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q21827","intActId":"EBI-2412202"},"interactantTwo":{"uniProtKBAccession":"Q19986","geneName":"wdr-83","intActId":"EBI-2417030"},"numberOfExperiments":4,"organismDiffer":false}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the GPATCH1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"G patch domain-containing protein 1 homolog","featureId":"PRO_0000287459"},{"type":"Domain","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"G-patch","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00092"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":584,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":668,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":720,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":761,"modifier":"EXACT"},"end":{"value":794,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":800,"modifier":"EXACT"},"end":{"value":812,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"9851916","citationType":"journal article","authoringGroup":["The C. elegans sequencing consortium"],"citationCrossReferences":[{"database":"PubMed","id":"9851916"},{"database":"DOI","id":"10.1126/science.282.5396.2012"}],"title":"Genome sequence of the nematode C. elegans: a platform for investigating biology.","publicationDate":"1998","journal":"Science","firstPage":"2012","lastPage":"2018","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Bristol N2","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z32683","properties":[{"key":"ProteinId","value":"CAA83621.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S43604","properties":[{"key":"EntryName","value":"S43604"}]},{"database":"RefSeq","id":"NP_497893.1","properties":[{"key":"NucleotideSequenceId","value":"NM_065492.6"}]},{"database":"AlphaFoldDB","id":"Q21827","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"40810","properties":[{"key":"Interactions","value":"7"}]},{"database":"FunCoup","id":"Q21827","properties":[{"key":"Number of interactors","value":"2561"}]},{"database":"IntAct","id":"Q21827","properties":[{"key":"Interactions","value":"3"}]},{"database":"STRING","id":"6239.R07E5.1.1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"6239-R07E5.1.1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q21827","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"R07E5.1.1","properties":[{"key":"ProteinId","value":"R07E5.1.1"},{"key":"GeneId","value":"WBGene00011109"}]},{"database":"GeneID","id":"175574","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cel:CELE_R07E5.1","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"R07E5.1","properties":[{"key":"OrganismName","value":"c. elegans"}]},{"database":"AGR","id":"WB:WBGene00011109","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"175574","properties":[{"key":"Description","value":"-"}]},{"database":"WormBase","id":"R07E5.1","properties":[{"key":"ProteinId","value":"CE00658"},{"key":"GeneId","value":"WBGene00011109"},{"key":"GeneName","value":"gpch-1"}]},{"database":"eggNOG","id":"KOG2138","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_008613_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q21827","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DQQKPDT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"20507at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q21827","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-CEL-72163","properties":[{"key":"PathwayName","value":"mRNA Splicing - Major Pathway"}]},{"database":"PRO","id":"PR:Q21827","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001940","properties":[{"key":"Component","value":"Chromosome III"}]},{"database":"Bgee","id":"WBGene00011109","properties":[{"key":"ExpressionPatterns","value":"Expressed in germ line (C elegans) and 4 other cell types or tissues"}]},{"database":"GO","id":"GO:0003676","properties":[{"key":"GoTerm","value":"F:nucleic acid binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006397","properties":[{"key":"GoTerm","value":"P:mRNA processing"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR011666","properties":[{"key":"EntryName","value":"DUF1604"}]},{"database":"InterPro","id":"IPR000467","properties":[{"key":"EntryName","value":"G_patch_dom"}]},{"database":"PANTHER","id":"PTHR13384","properties":[{"key":"EntryName","value":"G PATCH DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13384:SF19","properties":[{"key":"EntryName","value":"G PATCH DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07713","properties":[{"key":"EntryName","value":"DUF1604"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01585","properties":[{"key":"EntryName","value":"G-patch"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF26093","properties":[{"key":"EntryName","value":"HTH_TGH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00443","properties":[{"key":"EntryName","value":"G_patch"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50174","properties":[{"key":"EntryName","value":"G_PATCH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNRKKLAAYGQEFEDDDEEGSSVSKKPTQIHEEIATDEKGKRRFHGAFTGGFSAGYWNTVGSKQGWVPQVFSSSRNERGEQIKQRAEDFMDAEDLGEYGIGNRSIKQTAAFGEGAGQKRKMAWERDTTSISTITQMFEDVVKPVSNSIGVRMLRSMGWREGRGIGLANVKQKQKRGGESSEAQFDREQASKVAPAYEFSNEDALVKQLTPLTGTHGIGYQGLRKTTVLNESYGRTTLALKSGKKNSKGIKGQAFGVGAFEEEDESVYSNYDLSQFDFSLDVAGASEESNLKTQKLVTAFELQPKRLNPRKFYAPPRVPPNFRGDHRPIPMDISKLPQMMKNDVKHMNAEQRAKFLGEDRVNALEIGGKSSKKPTERRSRWDIKANEVEKRDNERGGGEAEEDRDRRQRNRIEFPDEPMRQARFKEFLHYIRRGLPYPQPTDLTVWEWEWEKKEFESKLTSDERGMLPEVQSRAQPLAKTAIAAPIHEMMASKFVKEAGGDLKVGTKDEDKLAAVKMEMFGEKTRQSFDWYPDNLLAKRFNVPHPYPGSDTVGVPALQKTDWKRKDRLADIGGVSATLGLPNTANEIEMRERLLKSRAQRGAEEKKRNQSDDDDEKEYDDKDSDEEEENEAEPNNQKVDKAPKSFFDFIFGDGDGADSDESNSEDEEAEEKERQEILKKREEDLKRRREIVEKKEEENRKRVEKELKELENRDLLRVSKQQEDDDIQIIDETSASSFGPALPPSSKPVLSKTEVLKLLEKNMKKKKKDKKEKEKKKKSKKSKKSKKEKKTKRKHSSSSADDSGDNSDGWEEKK","length":812,"molWeight":92630,"crc64":"E266247AFF0C7D82","md5":"41AE4DB3B835BA83CEE1E058DFAFAEC8"},"extraAttributes":{"countByCommentType":{"INTERACTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":3,"Compositional bias":7},"uniParcId":"UPI0000078C80"}}