{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q20762","uniProtkbId":"YAO6_CAEEL","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2005-05-10","entryVersion":136,"sequenceVersion":4},"annotationScore":3.0,"organism":{"scientificName":"Caenorhabditis elegans","taxonId":6239,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Rhabditina","Rhabditomorpha","Rhabditoidea","Rhabditidae","Peloderinae","Caenorhabditis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein F54D1.6"}},"flag":"Precursor"},"genes":[{"orfNames":[{"value":"F54D1.6"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":1423,"modifier":"EXACT"}},"description":"Uncharacterized protein F54D1.6","featureId":"PRO_0000014285"},{"type":"Topological domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":1321,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1322,"modifier":"EXACT"},"end":{"value":1342,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":1343,"modifier":"EXACT"},"end":{"value":1423,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"NIDO","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00570"}]},{"type":"Domain","location":{"start":{"value":638,"modifier":"EXACT"},"end":{"value":818,"modifier":"EXACT"}},"description":"AMOP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00347"}]},{"type":"Region","location":{"start":{"value":1364,"modifier":"EXACT"},"end":{"value":1401,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1378,"modifier":"EXACT"},"end":{"value":1401,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15888633"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15888633"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17761667"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":483,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15888633"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15888633"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17761667"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":903,"modifier":"EXACT"},"end":{"value":903,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17761667"}],"featureId":""}],"keywords":[{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9851916","citationType":"journal article","authoringGroup":["The C. elegans sequencing consortium"],"citationCrossReferences":[{"database":"PubMed","id":"9851916"},{"database":"DOI","id":"10.1126/science.282.5396.2012"}],"title":"Genome sequence of the nematode C. elegans: a platform for investigating biology.","publicationDate":"1998","journal":"Science","firstPage":"2012","lastPage":"2018","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Bristol N2","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"15888633","citationType":"journal article","authors":["Fan X.","She Y.-M.","Bagshaw R.D.","Callahan J.W.","Schachter H.","Mahuran D.J."],"citationCrossReferences":[{"database":"PubMed","id":"15888633"},{"database":"DOI","id":"10.1093/glycob/cwi075"}],"title":"Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.","publicationDate":"2005","journal":"Glycobiology","firstPage":"952","lastPage":"964","volume":"15"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-306; ASN-355; ASN-483 AND ASN-666","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":3,"citation":{"id":"17761667","citationType":"journal article","authors":["Kaji H.","Kamiie J.","Kawakami H.","Kido K.","Yamauchi Y.","Shinkawa T.","Taoka M.","Takahashi N.","Isobe T."],"citationCrossReferences":[{"database":"PubMed","id":"17761667"},{"database":"DOI","id":"10.1074/mcp.m600392-mcp200"}],"title":"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.","publicationDate":"2007","journal":"Mol. Cell. Proteomics","firstPage":"2100","lastPage":"2109","volume":"6"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-355; ASN-666 AND ASN-903","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Bristol N2","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z77132","properties":[{"key":"ProteinId","value":"CAB00863.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"T22643","properties":[{"key":"EntryName","value":"T22643"}]},{"database":"RefSeq","id":"NP_502119.2","properties":[{"key":"NucleotideSequenceId","value":"NM_069718.5"}]},{"database":"AlphaFoldDB","id":"Q20762","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q20762","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"43136","properties":[{"key":"Interactions","value":"2"}]},{"database":"FunCoup","id":"Q20762","properties":[{"key":"Number of interactors","value":"43"}]},{"database":"STRING","id":"6239.F54D1.6.2","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q20762","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"6239-F54D1.6.2","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q20762","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"F54D1.6.1","properties":[{"key":"ProteinId","value":"F54D1.6.1"},{"key":"GeneId","value":"WBGene00010047"}]},{"database":"GeneID","id":"178037","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cel:CELE_F54D1.6","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"F54D1.6","properties":[{"key":"OrganismName","value":"c. elegans"}]},{"database":"AGR","id":"WB:WBGene00010047","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"178037","properties":[{"key":"Description","value":"-"}]},{"database":"WormBase","id":"F54D1.6","properties":[{"key":"ProteinId","value":"CE37523"},{"key":"GeneId","value":"WBGene00010047"},{"key":"GeneName","value":"-"}]},{"database":"eggNOG","id":"KOG4291","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_004798_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q20762","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FIFLCCW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9972657at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q20762","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q20762","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001940","properties":[{"key":"Component","value":"Chromosome IV"}]},{"database":"Bgee","id":"WBGene00010047","properties":[{"key":"ExpressionPatterns","value":"Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007160","properties":[{"key":"GoTerm","value":"P:cell-matrix adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR005533","properties":[{"key":"EntryName","value":"AMOP_dom"}]},{"database":"InterPro","id":"IPR056075","properties":[{"key":"EntryName","value":"DUF7658"}]},{"database":"InterPro","id":"IPR051495","properties":[{"key":"EntryName","value":"Epithelial_Barrier/Signaling"}]},{"database":"InterPro","id":"IPR057017","properties":[{"key":"EntryName","value":"F54D1_6-like_C"}]},{"database":"InterPro","id":"IPR057018","properties":[{"key":"EntryName","value":"F54D1_6-like_Ig-like"}]},{"database":"InterPro","id":"IPR057019","properties":[{"key":"EntryName","value":"F54D1_6-like_Ig-like_2"}]},{"database":"InterPro","id":"IPR003886","properties":[{"key":"EntryName","value":"NIDO_dom"}]},{"database":"PANTHER","id":"PTHR13802","properties":[{"key":"EntryName","value":"MUCIN 4-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13802:SF60","properties":[{"key":"EntryName","value":"PROTEIN CBG06057"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03782","properties":[{"key":"EntryName","value":"AMOP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24678","properties":[{"key":"EntryName","value":"DUF7658"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24469","properties":[{"key":"EntryName","value":"F54D1_6_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24462","properties":[{"key":"EntryName","value":"Ig_F54D1_6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24464","properties":[{"key":"EntryName","value":"Ig_F54D1_6_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06119","properties":[{"key":"EntryName","value":"NIDO"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00723","properties":[{"key":"EntryName","value":"AMOP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00539","properties":[{"key":"EntryName","value":"NIDO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50856","properties":[{"key":"EntryName","value":"AMOP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51220","properties":[{"key":"EntryName","value":"NIDO"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTSSVRLAFLATLLLLLPLEAQIQQANSANVNQNVGQQDTGTLFTGTGTNLYYGVNLVPFGPEVGDQEVNPGLLTAGQTIDLHMYFPFYGGLYNYSTLSVNGYIGFATVLDQGPTLNVGPDMTDWPRHEDPAMIAPYLCKQQIPQNLNPGMRSGVFYRLMMRQSLFGRQTGSNMNMGQATYQSSFFGQSASKACPGTPDSYVRCDSQADYFLEEMQRWLIEGVAGAAAFRADAALVVTWYNTASAISGRSDIDSGQLATYQAIWLTDRTARLSYVILNYDRLGFDAADFRQNSRSGRCQALFNGGNHTGLVPVDPTQDFKNTPKVLAQRSGVPQMVRGRYMFRVDDVVRPAGCSNKTGGTYPMLIYPNIVNMLGEMTVDVNAICLDKSQTYILMIEQRQTATCTVLTSAIARCNLPKIFDWGTKTVYFQPQSGGANDEKAFVGYIYFVPPTLDPMRLDIGNVYDWFKNPLPYTTMPLVWYPRNFTNPEMTQHMDQVRMNDDTLYSTQLGLYVIAYREYKDDTIKKFRPEHRVICRLATYSNRNTYEYRWKPQEERINLYQVEQWYMNDWERQNDLYHYRFGYLKLAPLKTNQEQNPQQLLSGLVSSPISLHFLWTSNNPQFATTTYSQQDESARTEYVKKKSLEMCHDWYDEDGAQWNFIRDTETNSSCPCIERQAIADIGRFMPHPRCSQAFRDITCTTSIGSRNCYMSSQNVMTTYAGDGRQYNENLARFPTHYGQVCCYDDQGHLMQTSYQPVIKVTPEVPYNPGFPMRAYEFGTAPYMGQYEVPGLSAFHNDYMPYFLCCKFADFRCQMFYWRRPSSGCQEYQPPAYGEVMGAGTFNTIDNDKFIFNEPGVYNGLYIPHTLSTPEVKVQIRMERYPNRRVDFSLLGRYMAQQDLVQPTNATVVTGVVLEATGTDRVHVVARKDTRRFRYRTSIIVGNILRYFDTMRIQRFKGVMIYVNNVERGQPEIYVVLEEAQIGIRVRESYAIDIDRLSEYQESMGILNIAVSVPPQYGVRPDGDKTREQEIRQRYNLPRVSGVFRPFPDQSSGSYLNTLTLNDVNSETYRQQIINMYRVQGSGEPGSDQNINNQGNNYGMPTENMFTTSRDEDKKFEVFPEAQMKSGPIFKTSPKYETGAYRFYPMTGQVLNQRLQTCRDMQQNTNINMQPLQSQLTGEYGQTQCPDNPSSIIQDCGDSVPCLYDYYNFNAKLLGLNVKNEWNTFTSDRFDASRQYNSCGVINIEYPEYLMKTSSMSSAYLQGDVARFECFQSHWIYGVHEYKCGIVVDRNQRNIIDPRDYRFEWNKGEQPWCRSREKQNFLTWLAIIGGIFGVLVFVILIFLCCWIVKQKKKGEAAERRGYDMASRSSMTGSRGGKKYPIHESEPLNEKRFDADTYRDDDFYPPAREEQYAARNEDLHGLKTSV","length":1423,"molWeight":163201,"crc64":"3B779D522BF4FFE4","md5":"48E425BBB3381C3F4702CB864C7139B2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":2,"Region":1,"Compositional bias":1,"Glycosylation":6},"uniParcId":"UPI000044F605"}}