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Important during development for the up-regulation of mitochondrial activity during the transition to higher larval stages (PubMed:19888333). Regulates mitochondrial iron homeostasis (PubMed:26427876). May play an important role in mitochondrial protein synthesis (By similarity). May also participate in mitochondrial DNA replication (By similarity). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (By similarity). Plays a role in regulating the production of reactive oxygen species in response to heat stress (PubMed:22245785)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NVI7"}],"value":"In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19888333"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19888333"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NVI7"}],"value":"Mitochondrion matrix, mitochondrion nucleoid","id":"SL-0269"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19888333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22245785"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26427876"}],"value":"RNAi-mediated knockdown results in an increased adult lifespan (PubMed:22245785). RNAi-mediated knockdown at the L1 stage of larval development results in arrest in the majority of animals at this larval stage (PubMed:19888333). Some surviving animals arrest during the subsequent larval stages (PubMed:19888333). RNAi-mediated knockdown in young adults results in a gradual decrease in the reproduction rate over time whereby initially fewer embryos are produced as compared to wild-type animals, and eventually adults fail to reproduce (PubMed:19888333). The few embryos that are produced by the young adults are viable, but animals arrest at the L1 larval stage (PubMed:19888333). RNAi-mediated knockdown results in sufficient mitochondrial function at the L1 larval stage, and no obvious changes in mitochondrial mass (PubMed:19888333). However, RNAi-mediated knockdown results in defects in mitochondrial activity and structure characterized by reduced mitochondrial NADH-ubiquinone oxidoreductase and citrate synthase activity compared to wild-type animals at later stages of development, and a disorganized mitochondrial network with thinner mitochondria (PubMed:19888333). RNAi-mediated knockdown results in increased levels of reactive oxygen species as compared to wild-type animals at 37 degrees Celsius (PubMed:22245785). RNAi-mediated knockdown during early developmental stages and at the L3 larval stage results in increased levels of iron and heme (PubMed:26427876). RNAi-mediated knockdown in a mics-1 mutant background results in an enhanced increase in adult lifespan as compared to the single mutants and wild-type animals (PubMed:22245785)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the AAA ATPase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22245785"},{"evidenceCode":"ECO:0000305"}],"value":"Has been shown to interact (via C-terminus) with mics-1 (via PDZ domain) (PubMed:22245785). The physiological significance of this interaction is uncertain; the mics-1 PDZ domain is expected to be in the cytoplasm"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27506200"},{"evidenceCode":"ECO:0000305"}],"value":"Has been shown to interact (via C-terminus) with dlg-1 (via PDZ domain) (PubMed:22245785). 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