{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q1ZZU3","secondaryAccessions":["Q5SYX7","Q5SYX8","Q8N2W6"],"uniProtkbId":"SWI5_HUMAN","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-04-18","entryVersion":122,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"DNA repair protein SWI5 homolog"}},"alternativeNames":[{"fullName":{"value":"HBV DNAPTP1-transactivated protein A"}},{"fullName":{"value":"Protein SAE3 homolog"}}]},"genes":[{"geneName":{"value":"SWI5"},"synonyms":[{"value":"C9orf119"},{"value":"SAE3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21252223"}],"value":"Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21252223"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23754376"}],"value":"Component of the SWI5-SFR1 complex. Interacts with RAD51"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q1ZZU3","intActId":"EBI-20832852"},"interactantTwo":{"uniProtKBAccession":"Q86XK3","geneName":"SFR1","intActId":"EBI-1104535"},"numberOfExperiments":6,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SWI5/SAE3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"DNA repair protein SWI5 homolog","featureId":"PRO_0000324584"},{"type":"Region","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Mutagenesis","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Does not affect interaction with SFR1/MEI5.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21252223"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-BM5GMV03LR6N0","citationType":"submission","authors":["Lun Y.Z.","Cheng J.","Guo J.","Zhang L.Y.","Zhao B.C."],"title":"Homo sapiens HBV DNAPTP1-transactivated protein A.","publicationDate":"FEB-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.S.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.R.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.I.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.M.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-235"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21252223","citationType":"journal article","authors":["Yuan J.","Chen J."],"citationCrossReferences":[{"database":"PubMed","id":"21252223"},{"database":"DOI","id":"10.1074/jbc.m110.207290"}],"title":"The role of human SWI5-MEI5 complex in homologous recombination repair.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"9888","lastPage":"9893","volume":"286"},"referencePositions":["FUNCTION","IDENTIFICATION IN THE SWI5-SFR1 COMPLEX","INTERACTION WITH RAD51","MUTAGENESIS OF LEU-173"]},{"referenceNumber":5,"citation":{"id":"23754376","citationType":"journal article","authors":["Yuan J.","Chen J."],"citationCrossReferences":[{"database":"PubMed","id":"23754376"},{"database":"DOI","id":"10.1073/pnas.1220662110"}],"title":"FIGNL1-containing protein complex is required for efficient homologous recombination repair.","publicationDate":"2013","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10640","lastPage":"10645","volume":"110"},"referencePositions":["INTERACTION WITH RAD51"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ414820","properties":[{"key":"ProteinId","value":"ABD72916.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL590708","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC029911","properties":[{"key":"ProteinId","value":"AAH29911.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001035100.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001040011.2"}]},{"database":"RefSeq","id":"NP_001305018.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001318089.2"}]},{"database":"RefSeq","id":"NP_001305021.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318092.2"}]},{"database":"AlphaFoldDB","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"131997","properties":[{"key":"Interactions","value":"3"}]},{"database":"ComplexPortal","id":"CPX-8093","properties":[{"key":"EntryName","value":"SWI5-SFR1 recombination accessory factor complex"}]},{"database":"FunCoup","id":"Q1ZZU3","properties":[{"key":"Number of interactors","value":"217"}]},{"database":"IntAct","id":"Q1ZZU3","properties":[{"key":"Interactions","value":"3"}]},{"database":"STRING","id":"9606.ENSP00000316609","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q1ZZU3","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SWI5","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"121940938","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000316609","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"61258","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"375757","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"375757","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:375757","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc004bup.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:31412","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134903574","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"375757","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"375757","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SWI5","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:31412","properties":[{"key":"GeneName","value":"SWI5"}]},{"database":"MIM","id":"616528","properties":[{"key":"Type","value":"gene"}]},{"database":"eggNOG","id":"ENOG502S8Z3","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"255837at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q1ZZU3","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"375757","properties":[{"key":"hits","value":"16 hits in 281 CRISPR screens"}]},{"database":"ChiTaRS","id":"SWI5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"375757","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q1ZZU3","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q1ZZU3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"Q1ZZU3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0000228","properties":[{"key":"GoTerm","value":"C:nuclear chromosome"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21252223"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032798","properties":[{"key":"GoTerm","value":"C:Swi5-Sfr1 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21252223"}]},{"database":"GO","id":"GO:0071479","properties":[{"key":"GoTerm","value":"P:cellular response to ionizing radiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23754376"}]},{"database":"GO","id":"GO:0000724","properties":[{"key":"GoTerm","value":"P:double-strand break repair via homologous recombination"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21252223"}]},{"database":"GO","id":"GO:0000707","properties":[{"key":"GoTerm","value":"P:meiotic DNA recombinase assembly"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21252223"}]},{"database":"GO","id":"GO:0007131","properties":[{"key":"GoTerm","value":"P:reciprocal meiotic recombination"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21252223"}]},{"database":"FunFam","id":"1.20.5.170:FF:000056","properties":[{"key":"EntryName","value":"DNA repair protein SWI5 homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010760","properties":[{"key":"EntryName","value":"DNA-repair_Swi5"}]},{"database":"PANTHER","id":"PTHR28529","properties":[{"key":"EntryName","value":"DNA REPAIR PROTEIN SWI5 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28529:SF2","properties":[{"key":"EntryName","value":"DNA REPAIR PROTEIN SWI5 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07061","properties":[{"key":"EntryName","value":"Swi5"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQRRGQRDLWRHNKSCARNRCPRPPRERGGAGFPWVRAQLSVRQFTLRVRVPGPVHLRGRSPTPALDPLAPLNPLIRGPRTPGLRRWIQSLALLLPNCSSSRIPTVPRPHSGLWVQSDFPLGFLSRTEPRLTRSCRGAFRSPRPLPKSGQADGTSEESLHLDIQKLKEKRDMLDKEISQFVSEGYSVDELEDHITQLHEYNDIKDVGQMLMGKLAVIRGVTTKELYPEFGLDMND","length":235,"molWeight":26739,"crc64":"5DCA1CE228987987","md5":"30CFB843EC01B5070D87202D4AF1D4E1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Coiled coil":1,"Mutagenesis":1},"uniParcId":"UPI00001D76F5"}}