{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q1RMZ1","secondaryAccessions":["Q8N3D0","Q96MV7"],"uniProtkbId":"SAMTR_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-05-16","entryVersion":137,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29123071"}],"value":"S-adenosylmethionine sensor upstream of mTORC1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"}],"value":"Probable methyltransferase BMT2 homolog"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"}],"value":"2.1.1.-"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29123071"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:26475"}],"value":"SAMTOR"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"}],"value":"BMT2"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:26475"}],"value":"C7orf60"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29123071"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35776786"}],"value":"S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071, PubMed:35776786). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29123071"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29590090"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35776786"}],"value":"Interacts with the DEPDC5 subunit of the GATOR1 complex; interaction is disrupted when SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071, PubMed:29590090, PubMed:35776786). Interacts with the KICSTOR complex; interaction is disrupted when SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071, PubMed:35776786)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"}],"value":"Belongs to the BMT2/SAMTOR family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAB71169.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"S-adenosylmethionine sensor upstream of mTORC1","featureId":"PRO_0000321539"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35776786"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29123071"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29123071"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35776786"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03044"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Mutagenesis","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Abolished binding to S-adenosyl-L-methionine without affecting ability to associate with GATOR1 and KICSTOR complexes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35776786"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Strongly decreased ability to associate with GATOR1 and KICSTOR complexes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35776786"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Abolished binding to S-adenosyl-L-methionine without affecting ability to associate with GATOR1 and KICSTOR complexes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35776786"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Abolished binding to S-adenosyl-L-methionine without affecting ability to associate with GATOR1 and KICSTOR complexes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35776786"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"in Ref. 1; BAB71169","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-405"],"referenceComments":[{"value":"Melanoma","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"29123071","citationType":"journal article","authors":["Gu X.","Orozco J.M.","Saxton R.A.","Condon K.J.","Liu G.Y.","Krawczyk P.A.","Scaria S.M.","Harper J.W.","Gygi S.P.","Sabatini D.M."],"citationCrossReferences":[{"database":"PubMed","id":"29123071"},{"database":"DOI","id":"10.1126/science.aao3265"}],"title":"SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.","publicationDate":"2017","journal":"Science","firstPage":"813","lastPage":"818","volume":"358"},"referencePositions":["FUNCTION","INTERACTION WITH THE GATOR1 AND KICSTOR COMPLEXES"]},{"referenceNumber":6,"citation":{"id":"29590090","citationType":"journal article","authors":["Shen K.","Huang R.K.","Brignole E.J.","Condon K.J.","Valenstein M.L.","Chantranupong L.","Bomaliyamu A.","Choe A.","Hong C.","Yu Z.","Sabatini D.M."],"citationCrossReferences":[{"database":"PubMed","id":"29590090"},{"database":"DOI","id":"10.1038/nature26158"}],"title":"Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.","publicationDate":"2018","journal":"Nature","firstPage":"64","lastPage":"69","volume":"556"},"referencePositions":["INTERACTION WITH DEPDC5"]},{"referenceNumber":7,"citation":{"id":"35776786","citationType":"journal article","authors":["Tang X.","Zhang Y.","Wang G.","Zhang C.","Wang F.","Shi J.","Zhang T.","Ding J."],"citationCrossReferences":[{"database":"PubMed","id":"35776786"},{"database":"DOI","id":"10.1126/sciadv.abn3868"}],"title":"Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling.","publicationDate":"2022","journal":"Sci. Adv.","firstPage":"eabn3868","lastPage":"eabn3868","volume":"8"},"referencePositions":["FUNCTION","INTERACTION WITH THE GATOR1 AND KICSTOR COMPLEXES","MUTAGENESIS OF ARG-95; PHE-175; ASP-190 AND ASP-202"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK056380","properties":[{"key":"ProteinId","value":"BAB71169.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471070","properties":[{"key":"ProteinId","value":"EAW83474.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC114615","properties":[{"key":"ProteinId","value":"AAI14616.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL834437","properties":[{"key":"ProteinId","value":"CAD39097.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS43634.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_689769.2","properties":[{"key":"NucleotideSequenceId","value":"NM_152556.3"}]},{"database":"PDB","id":"9O5D","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.34 A"},{"key":"Chains","value":"A=1-405"}]},{"database":"PDBsum","id":"9O5D","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70140","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"127552","properties":[{"key":"Interactions","value":"22"}]},{"database":"FunCoup","id":"Q1RMZ1","properties":[{"key":"Number of interactors","value":"1454"}]},{"database":"IntAct","id":"Q1RMZ1","properties":[{"key":"Interactions","value":"25"}]},{"database":"MINT","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000297145","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q1RMZ1","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"BMT2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"121947576","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000297145","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"61242","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"50763","properties":[{"key":"antibodies","value":"12 antibodies from 8 providers"}]},{"database":"DNASU","id":"154743","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000297145.9","properties":[{"key":"ProteinId","value":"ENSP00000297145.4"},{"key":"GeneId","value":"ENSG00000164603.13"}]},{"database":"GeneID","id":"154743","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:154743","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000297145.9","properties":[{"key":"ProteinId","value":"ENSP00000297145.4"},{"key":"RefSeqNucleotideId","value":"NM_152556.3"},{"key":"RefSeqProteinId","value":"NP_689769.2"}]},{"database":"UCSC","id":"uc003vgo.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:26475","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162380700","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"154743","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SAMTOR","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26475","properties":[{"key":"GeneName","value":"SAMTOR"}]},{"database":"HPA","id":"ENSG00000164603","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"617855","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000164603","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000164603","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QRK4","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000010382","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_036404_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CCQKAYE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5954793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q1RMZ1","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9639288","properties":[{"key":"PathwayName","value":"Amino acids regulate mTORC1"}]},{"database":"SignaLink","id":"Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000164603","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"154743","properties":[{"key":"hits","value":"11 hits in 1140 CRISPR screens"}]},{"database":"ChiTaRS","id":"BMT2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"154743","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q1RMZ1","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q1RMZ1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q1RMZ1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000164603","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 174 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q1RMZ1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0008168","properties":[{"key":"GoTerm","value":"F:methyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29123071"}]},{"database":"GO","id":"GO:1904047","properties":[{"key":"GoTerm","value":"F:S-adenosyl-L-methionine binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29123071"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35776786"}]},{"database":"GO","id":"GO:0034198","properties":[{"key":"GoTerm","value":"P:cellular response to amino acid starvation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29123071"}]},{"database":"GO","id":"GO:0061431","properties":[{"key":"GoTerm","value":"P:cellular response to methionine"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29123071"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35776786"}]},{"database":"GO","id":"GO:1904263","properties":[{"key":"GoTerm","value":"P:positive regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29123071"}]},{"database":"GO","id":"GO:1903432","properties":[{"key":"GoTerm","value":"P:regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29123071"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35776786"}]},{"database":"FunFam","id":"3.40.50.150:FF:000089","properties":[{"key":"EntryName","value":"S-adenosylmethionine sensor upstream of mTORC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03044","properties":[{"key":"EntryName","value":"BMT2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR021867","properties":[{"key":"EntryName","value":"Bmt2/SAMTOR"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR21008:SF0","properties":[{"key":"EntryName","value":"S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21008","properties":[{"key":"EntryName","value":"S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11968","properties":[{"key":"EntryName","value":"Bmt2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS","length":405,"molWeight":46324,"crc64":"5C19614953ABD670","md5":"FA6D4858FEDEA0296E1E307D258D1949"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Binding site":6,"Mutagenesis":4,"Sequence conflict":1},"uniParcId":"UPI000020F946"}}