{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q1RMI8","uniProtkbId":"CCD22_BOVIN","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-05-16","entryVersion":96,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bos taurus","commonName":"Bovine","taxonId":9913,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Laurasiatheria","Artiodactyla","Ruminantia","Pecora","Bovidae","Bovinae","Bos"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Coiled-coil domain-containing protein 22"}}},"genes":[{"geneName":{"value":"CCDC22"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O60826"}],"value":"Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (By similarity). Involved in regulation of NF-kappa-B signaling (By similarity). Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex (By similarity). May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (By similarity). Plays a role in copper ion homeostasis (By similarity). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O60826"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JIG7"}],"value":"Component of the commander complex consisting of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the CCC (COMMD/CCDC22/CCDC93) subcomplex consisting of COMMD1, COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, CCDC22 and CCDC93 (By similarity). Forms a coiled-coil heterodimer with CCDC22; this heterodimer interacts with the guanine nucleotide exchange factor DENND10; the interaction is direct (By similarity). Interacts with CUL1, CUL2, CUL3, SKP1, BTRC (By similarity). Interacts with SNX17 and SNX31 (By similarity). Interacts with CPNE1 and CPNE4 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O60826"}],"value":"Endosome","id":"SL-0101"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O60826"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CCDC22 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":595,"modifier":"EXACT"}},"description":"Coiled-coil domain-containing protein 22","featureId":"PRO_0000338399"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Sufficicient and required for interaction with 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