{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q1R3Z0","uniProtkbId":"ZAPB_ECOUT","entryAudit":{"firstPublicDate":"2008-05-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-05-20","entryVersion":87,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Escherichia coli (strain UTI89 / UPEC)","taxonId":364106,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Cell division protein ZapB"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"zapB"},"orderedLocusNames":[{"value":"UTI89_C4512"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Localizes to the septum at mid-cell, in a FtsZ-like pattern"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}],"value":"Belongs to the ZapB family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"ABE09924.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Cell division protein ZapB","featureId":"PRO_0000333899"},{"type":"Region","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}]},{"type":"Compositional bias","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01196"}]}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0717","category":"Biological process","name":"Septation"}],"references":[{"referenceNumber":1,"citation":{"id":"16585510","citationType":"journal article","authors":["Chen S.L.","Hung C.-S.","Xu J.","Reigstad C.S.","Magrini V.","Sabo A.","Blasiar D.","Bieri T.","Meyer R.R.","Ozersky P.","Armstrong J.R.","Fulton R.S.","Latreille J.P.","Spieth J.","Hooton T.M.","Mardis E.R.","Hultgren S.J.","Gordon J.I."],"citationCrossReferences":[{"database":"PubMed","id":"16585510"},{"database":"DOI","id":"10.1073/pnas.0600938103"}],"title":"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5977","lastPage":"5982","volume":"103"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"UTI89 / UPEC","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP000243","properties":[{"key":"ProteinId","value":"ABE09924.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_001296623.1","properties":[{"key":"NucleotideSequenceId","value":"NC_007946.1"}]},{"database":"AlphaFoldDB","id":"Q1R3Z0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q1R3Z0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"67174954","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"93777970","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"eci:UTI89_C4512","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_171174_2_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0090529","properties":[{"key":"GoTerm","value":"P:cell septum assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043093","properties":[{"key":"GoTerm","value":"P:FtsZ-dependent cytokinesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"1.20.5.340:FF:000014","properties":[{"key":"EntryName","value":"Cell division protein ZapB"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01196","properties":[{"key":"EntryName","value":"ZapB"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009252","properties":[{"key":"EntryName","value":"Cell_div_ZapB"}]},{"database":"NCBIfam","id":"NF011951","properties":[{"key":"EntryName","value":"PRK15422.1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06005","properties":[{"key":"EntryName","value":"ZapB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTMSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQEVQNAQHQREELERENNHLKEQQNGWQERLQALLGRMEEV","length":81,"molWeight":9635,"crc64":"B01DC1A433A1D01B","md5":"D08945678E24C1ED1AD25FC20C27125F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Coiled coil":1,"Compositional bias":2,"Modified residue":1},"uniParcId":"UPI000013B41B"}}