{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q1LY51","uniProtkbId":"ZN704_DANRE","entryAudit":{"firstPublicDate":"2007-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-10-05","entryVersion":99,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Danio rerio","commonName":"Zebrafish","synonyms":["Brachydanio rerio"],"taxonId":7955,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Ostariophysi","Cypriniformes","Danionidae","Danioninae","Danio"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Zinc finger protein 704"}}},"genes":[{"geneName":{"value":"znf704"},"orfNames":[{"value":"si:ch211-203l9.2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ERQ3"}],"value":"Transcription factor"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ERQ3"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ERQ3"}],"value":"The CR1 and CR2 motifs mediate sequence-specific DNA binding"}],"commentType":"DOMAIN"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"Zinc finger protein 704","featureId":"PRO_0000288826"},{"type":"Zinc finger","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00042"}]},{"type":"Region","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"CR1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ERQ3"}]},{"type":"Motif","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"CR2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ERQ3"}]},{"type":"Compositional bias","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"23594743","citationType":"journal article","authors":["Howe K.","Clark M.D.","Torroja C.F.","Torrance J.","Berthelot C.","Muffato M.","Collins J.E.","Humphray S.","McLaren K.","Matthews L.","McLaren S.","Sealy I.","Caccamo M.","Churcher C.","Scott C.","Barrett J.C.","Koch R.","Rauch G.J.","White S.","Chow W.","Kilian B.","Quintais L.T.","Guerra-Assuncao J.A.","Zhou Y.","Gu Y.","Yen J.","Vogel J.H.","Eyre T.","Redmond S.","Banerjee R.","Chi J.","Fu B.","Langley E.","Maguire S.F.","Laird G.K.","Lloyd D.","Kenyon E.","Donaldson S.","Sehra H.","Almeida-King J.","Loveland J.","Trevanion S.","Jones M.","Quail M.","Willey D.","Hunt A.","Burton J.","Sims S.","McLay K.","Plumb B.","Davis J.","Clee C.","Oliver K.","Clark R.","Riddle C.","Elliot D.","Threadgold G.","Harden G.","Ware D.","Begum S.","Mortimore B.","Kerry G.","Heath P.","Phillimore B.","Tracey A.","Corby N.","Dunn M.","Johnson C.","Wood J.","Clark S.","Pelan S.","Griffiths G.","Smith M.","Glithero R.","Howden P.","Barker N.","Lloyd C.","Stevens C.","Harley J.","Holt K.","Panagiotidis G.","Lovell J.","Beasley H.","Henderson C.","Gordon D.","Auger K.","Wright D.","Collins J.","Raisen C.","Dyer L.","Leung K.","Robertson L.","Ambridge K.","Leongamornlert D.","McGuire S.","Gilderthorp R.","Griffiths C.","Manthravadi D.","Nichol S.","Barker G.","Whitehead S.","Kay M.","Brown J.","Murnane C.","Gray E.","Humphries M.","Sycamore N.","Barker D.","Saunders D.","Wallis J.","Babbage A.","Hammond S.","Mashreghi-Mohammadi M.","Barr L.","Martin S.","Wray P.","Ellington A.","Matthews N.","Ellwood M.","Woodmansey R.","Clark G.","Cooper J.","Tromans A.","Grafham D.","Skuce C.","Pandian R.","Andrews R.","Harrison E.","Kimberley A.","Garnett J.","Fosker N.","Hall R.","Garner P.","Kelly D.","Bird C.","Palmer S.","Gehring I.","Berger A.","Dooley C.M.","Ersan-Urun Z.","Eser C.","Geiger H.","Geisler M.","Karotki L.","Kirn A.","Konantz J.","Konantz M.","Oberlander M.","Rudolph-Geiger S.","Teucke M.","Lanz C.","Raddatz G.","Osoegawa K.","Zhu B.","Rapp A.","Widaa S.","Langford C.","Yang F.","Schuster S.C.","Carter N.P.","Harrow J.","Ning Z.","Herrero J.","Searle S.M.","Enright A.","Geisler R.","Plasterk R.H.","Lee C.","Westerfield M.","de Jong P.J.","Zon L.I.","Postlethwait J.H.","Nusslein-Volhard C.","Hubbard T.J.","Roest Crollius H.","Rogers J.","Stemple D.L."],"citationCrossReferences":[{"database":"PubMed","id":"23594743"},{"database":"DOI","id":"10.1038/nature12111"}],"title":"The zebrafish reference genome sequence and its relationship to the human genome.","publicationDate":"2013","journal":"Nature","firstPage":"498","lastPage":"503","volume":"496"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Tuebingen","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX119962","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001038383.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001044918.2"}]},{"database":"AlphaFoldDB","id":"Q1LY51","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q1LY51","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q1LY51","properties":[{"key":"Number of interactors","value":"1096"}]},{"database":"STRING","id":"7955.ENSDARP00000082791","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q1LY51","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PaxDb","id":"7955-ENSDARP00000082791","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q1LY51","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSDART00000088358","properties":[{"key":"ProteinId","value":"ENSDARP00000082791"},{"key":"GeneId","value":"ENSDARG00000061718"}]},{"database":"GeneID","id":"560056","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dre:560056","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"ZFIN:ZDB-GENE-060503-775","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"619279","properties":[{"key":"Description","value":"-"}]},{"database":"ZFIN","id":"ZDB-GENE-060503-775","properties":[{"key":"GeneName","value":"znf704"}]},{"database":"eggNOG","id":"ENOG502QTDT","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156172","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_032989_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q1LY51","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QKVEGSC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5950721at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q1LY51","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q1LY51","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000437","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSDARG00000061718","properties":[{"key":"ExpressionPatterns","value":"Expressed in retina and 15 other cell types or tissues"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR052253","properties":[{"key":"EntryName","value":"CR1/CR2-DNA-binding_regulator"}]},{"database":"InterPro","id":"IPR031940","properties":[{"key":"EntryName","value":"ZNF395/ZNF704_N"}]},{"database":"InterPro","id":"IPR013087","properties":[{"key":"EntryName","value":"Znf_C2H2_type"}]},{"database":"PANTHER","id":"PTHR13006","properties":[{"key":"EntryName","value":"PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13006:SF7","properties":[{"key":"EntryName","value":"ZINC FINGER PROTEIN 704"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15997","properties":[{"key":"EntryName","value":"DUF4772"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27556","properties":[{"key":"EntryName","value":"ZNF704_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01366","properties":[{"key":"EntryName","value":"c-clamp"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00355","properties":[{"key":"EntryName","value":"ZnF_C2H2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00028","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50157","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHTRRLVKRSVIGSRVYAPGLTGDAAPLTGVIQAVKQDNRDASTGHRRNVYTVLMQDGSVKEYSEEEIAQMTAKAPLKSSLKSTCNGGQRDGLTQGQNGGVQRGEALSLSPESTEEPRVLEHKRTGRALETEKDHTRSVSLLEQKRKVVSSSIDVPQARKSEEEVDMDKVTAAMVLTSLSTSPLVRSPPVKVSEGLNGSWKDGGFTPSSYSSSGYWSWSAPSDQSNPSTPSPPLSADSFKPFRMPSLSGPPDDNIDEHDGNSLLFDEPIPRKRKNSMKVMFKCLWKNCGKVLSTAAGIQRHIRTVHLGRNCDSECSDGEEDFYYTEIKLNTDSVADGLSSLSPVSPSVLSPPPALDQRQPDGTNGTKSESSSSTPLSRSAPSALYLVHTDHAYQATTPVTIPSTSSTGFTPSSSSFSISWQSPPVTFTGTSASPTHSRTQGFGEQHSQTIAVLSSPPRAAGSLSRKSRGEGKKCRKVYGMENRDMWCTACRWKKACQRFVD","length":501,"molWeight":54294,"crc64":"10E81DE5DED32550","md5":"5F6B3559D3371F77664BC4FE5EEFC77A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1},"countByFeatureType":{"Chain":1,"Zinc finger":1,"Region":7,"Motif":2,"Compositional bias":3},"uniParcId":"UPI0001A4206F"}}