{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q1G3U6","secondaryAccessions":["Q8L8X2","Q940G4"],"uniProtkbId":"PCO3_ARATH","entryAudit":{"firstPublicDate":"2015-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-06-27","entryVersion":118,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24599061"}],"value":"Plant cysteine oxidase 3"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29848548"}],"value":"AtPCO3"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24599061"}],"value":"1.13.11.20"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18978034"}],"value":"NIFS-like protein 2"},"shortNames":[{"value":"NifS2"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24599061"}],"value":"PCO3"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18978034"}],"value":"CpNIFS2"}],"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT1G18490"}],"value":"At1g18490"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AC013354"}],"value":"F15H18.26"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24599061"}],"value":"Catalyzes the oxidation of N-terminal cysteine residues (N-Cys), thus preparing the protein for N-end rule pathway-mediated proteasomal degradation, upstream of the N-end rule enzymes ATE1, ATE2 and PRT6 (Probable) (PubMed:29848548). Controls the preparation of the group VII ethylene response factor (ERF-VII) proteins for degradation via the 26S proteasome N-end rule pathway (Probable) (PubMed:29848548). Acts as an oxygen sensor that controls the stability of ERF-VII proteins, which are stabilized in flooding-induced hypoxia, and regulate transcriptional adaptation to these adverse conditions (Probable) (PubMed:29848548)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-cysteine + O2 = 3-sulfino-L-alanine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20441"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:35235"},{"database":"ChEBI","id":"CHEBI:61085"}],"ecNumber":"1.13.11.20","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24599061"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:20442"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24599061"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Fe(2+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9SJI9"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29033"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9SJI9"}],"value":"Binds 1 Fe(2+) cation per subunit."}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":8.43,"unit":"umol/min/mg","enzyme":"enzyme with CGGAIISDFIPPPR peptide as substrate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"}]}],"michaelisConstants":[{"constant":0.56,"unit":"mM","substrate":"CGGAIISDFIPPPR peptide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"}],"value":"kcat is 4.7 sec(-1) with CGGAIISDFIPPPR peptide as substrate."}]}},"phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"}],"value":"Optimum pH is 8.5 with CGGAIISDFIPPPR peptide as substrate."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24599061"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24599061"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q1G3U6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q1G3U6-2"],"sequenceIds":["VSP_057518"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the cysteine dioxygenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18978034"}],"value":"Was originally identified as a putative plastidic SufS-like protein and thus called CpNifS2"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAK96846.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAM67070.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Plant cysteine oxidase 3","featureId":"PRO_0000432451"},{"type":"Binding site","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9SJI9"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9SJI9"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9SJI9"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","note":"catalytic"}},{"type":"Alternative sequence","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_057518","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in Ref. 5; AAM67070","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0408","category":"Ligand","name":"Iron"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11130712","citationType":"journal article","authors":["Theologis A.","Ecker J.R.","Palm C.J.","Federspiel N.A.","Kaul S.","White O.","Alonso J.","Altafi H.","Araujo R.","Bowman C.L.","Brooks S.Y.","Buehler E.","Chan A.","Chao Q.","Chen H.","Cheuk R.F.","Chin C.W.","Chung M.K.","Conn L.","Conway A.B.","Conway A.R.","Creasy T.H.","Dewar K.","Dunn P.","Etgu P.","Feldblyum T.V.","Feng J.-D.","Fong B.","Fujii C.Y.","Gill J.E.","Goldsmith A.D.","Haas B.","Hansen N.F.","Hughes B.","Huizar L.","Hunter J.L.","Jenkins J.","Johnson-Hopson C.","Khan S.","Khaykin E.","Kim C.J.","Koo H.L.","Kremenetskaia I.","Kurtz D.B.","Kwan A.","Lam B.","Langin-Hooper S.","Lee A.","Lee J.M.","Lenz C.A.","Li J.H.","Li Y.-P.","Lin X.","Liu S.X.","Liu Z.A.","Luros J.S.","Maiti R.","Marziali A.","Militscher J.","Miranda M.","Nguyen M.","Nierman W.C.","Osborne B.I.","Pai G.","Peterson J.","Pham P.K.","Rizzo M.","Rooney T.","Rowley D.","Sakano H.","Salzberg S.L.","Schwartz J.R.","Shinn P.","Southwick A.M.","Sun H.","Tallon L.J.","Tambunga G.","Toriumi M.J.","Town C.D.","Utterback T.","Van Aken S.","Vaysberg M.","Vysotskaia V.S.","Walker M.","Wu D.","Yu G.","Fraser C.M.","Venter J.C.","Davis R.W."],"citationCrossReferences":[{"database":"PubMed","id":"11130712"},{"database":"DOI","id":"10.1038/35048500"}],"title":"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"816","lastPage":"820","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"17147637","citationType":"journal article","authors":["Underwood B.A.","Vanderhaeghen R.","Whitford R.","Town C.D.","Hilson P."],"citationCrossReferences":[{"database":"PubMed","id":"17147637"},{"database":"DOI","id":"10.1111/j.1467-7652.2006.00183.x"}],"title":"Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations.","publicationDate":"2006","journal":"Plant Biotechnol. J.","firstPage":"317","lastPage":"324","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-3TH3AFLAVIRO9","citationType":"submission","authors":["Brover V.V.","Troukhan M.E.","Alexandrov N.A.","Lu Y.-P.","Flavell R.B.","Feldmann K.A."],"title":"Full-length cDNA from Arabidopsis thaliana.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":6,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-282 (ISOFORM 2)"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"18978034","citationType":"journal article","authors":["Schippers J.H.","Nunes-Nesi A.","Apetrei R.","Hille J.","Fernie A.R.","Dijkwel P.P."],"citationCrossReferences":[{"database":"PubMed","id":"18978034"},{"database":"DOI","id":"10.1105/tpc.107.056341"}],"title":"The Arabidopsis onset of leaf death5 mutation of quinolinate synthase affects nicotinamide adenine dinucleotide biosynthesis and causes early ageing.","publicationDate":"2008","journal":"Plant Cell","firstPage":"2909","lastPage":"2925","volume":"20"},"referencePositions":["IDENTIFICATION"]},{"referenceNumber":8,"citation":{"id":"24599061","citationType":"journal article","authors":["Weits D.A.","Giuntoli B.","Kosmacz M.","Parlanti S.","Hubberten H.M.","Riegler H.","Hoefgen R.","Perata P.","van Dongen J.T.","Licausi F."],"citationCrossReferences":[{"database":"PubMed","id":"24599061"},{"database":"DOI","id":"10.1038/ncomms4425"}],"title":"Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"3425","lastPage":"3425","volume":"5"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","GENE FAMILY","NOMENCLATURE","SUBCELLULAR LOCATION"]},{"referenceNumber":9,"citation":{"id":"29848548","citationType":"journal article","authors":["White M.D.","Kamps J.J.A.G.","East S.","Taylor Kearney L.J.","Flashman E."],"citationCrossReferences":[{"database":"PubMed","id":"29848548"},{"database":"DOI","id":"10.1074/jbc.ra118.003496"}],"title":"The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors.","publicationDate":"2018","journal":"J. Biol. Chem.","firstPage":"11786","lastPage":"11795","volume":"293"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC013354","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002684","properties":[{"key":"ProteinId","value":"AEE29722.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408683","properties":[{"key":"ProteinId","value":"CAO7027830.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"DQ487488","properties":[{"key":"ProteinId","value":"ABF59200.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY088754","properties":[{"key":"ProteinId","value":"AAM67070.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY054655","properties":[{"key":"ProteinId","value":"AAK96846.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY072501","properties":[{"key":"ProteinId","value":"AAL66916.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_564055.1","properties":[{"key":"NucleotideSequenceId","value":"NM_101707.4"}],"isoformId":"Q1G3U6-1"},{"database":"AlphaFoldDB","id":"Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q1G3U6","properties":[{"key":"Number of interactors","value":"2263"}]},{"database":"IntAct","id":"Q1G3U6","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"3702.Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"236444","properties":[{"key":"Description","value":"-"}],"isoformId":"Q1G3U6-1"},{"database":"GeneID","id":"838430","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT1G18490","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT1G18490","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT1G18490","properties":[{"key":"GeneName","value":"PCO3"}]},{"database":"eggNOG","id":"KOG4281","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_061320_3_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KVSVRCF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"271433at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"SABIO-RK","id":"Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q1G3U6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"Q1G3U6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0017172","properties":[{"key":"GoTerm","value":"F:cysteine dioxygenase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29848548"}]},{"database":"GO","id":"GO:0005506","properties":[{"key":"GoTerm","value":"F:iron ion binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"33207269"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29848548"}]},{"database":"GO","id":"GO:0070483","properties":[{"key":"GoTerm","value":"P:detection of hypoxia"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29848548"}]},{"database":"GO","id":"GO:0018171","properties":[{"key":"GoTerm","value":"P:peptidyl-cysteine oxidation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29848548"}]},{"database":"CDD","id":"cd20289","properties":[{"key":"EntryName","value":"cupin_ADO"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.10","properties":[{"key":"EntryName","value":"Jelly Rolls"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012864","properties":[{"key":"EntryName","value":"PCO/ADO"}]},{"database":"InterPro","id":"IPR014710","properties":[{"key":"EntryName","value":"RmlC-like_jellyroll"}]},{"database":"InterPro","id":"IPR011051","properties":[{"key":"EntryName","value":"RmlC_Cupin_sf"}]},{"database":"PANTHER","id":"PTHR22966","properties":[{"key":"EntryName","value":"2-AMINOETHANETHIOL DIOXYGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22966:SF29","properties":[{"key":"EntryName","value":"PLANT CYSTEINE OXIDASE 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07847","properties":[{"key":"EntryName","value":"PCO_ADO"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51182","properties":[{"key":"EntryName","value":"RmlC-like cupins"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLSRLFKAGEKVLSNLVSKKDIYMASRNQEKSPKVQELYDLCKETFTGKAPSPASMAIQKLCSVLDSVSPADVGLEEVSQDDDRGYGVSGVSRFNRVGRWAQPITFLDIHECDTFTMCIFCFPTSSVIPLHDHPEMAVFSKILYGSLHVKAYDWVEPPCIITQDKGVPGSLPARLAKLVSDKVITPQSEIPALYPKTGGNLHCFTALTPCAVLDILSPPYKESVGRSCSYYMDYPFSTFALENGMKKVDEGKEDEYAWLVQIDTPDDLHMRPGSYTGPTIRV","length":282,"molWeight":31291,"crc64":"342F69567E6136F6","md5":"D0B7DF4156EC3743E39F9562145CD7B6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Binding site":3,"Alternative sequence":1,"Sequence conflict":1},"uniParcId":"UPI0000162DEF"}}