ID   RIC7_ARATH              Reviewed;         216 AA.
AC   Q1G3K8;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   02-SEP-2026, entry version 77.
DE   RecName: Full=CRIB domain-containing protein RIC7;
DE   AltName: Full=ROP-interactive CRIB motif-containing protein 7;
DE   AltName: Full=Target of ROP protein RIC7;
GN   Name=RIC7; OrderedLocusNames=At4g28556; ORFNames=F20O9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Resource (TAIR);
RT   "Community-consensus reference genome of Arabidopsis thaliana Col-0.";
RL   Submitted (FEB-2026) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [5]
RP   FUNCTION, INTERACTION WITH ARAC11/ROP1, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11752391; DOI=10.1105/tpc.010218;
RA   Wu G., Gu Y., Li S., Yang Z.;
RT   "A genome-wide analysis of Arabidopsis Rop-interactive CRIB motif-
RT   containing proteins that act as Rop GTPase targets.";
RL   Plant Cell 13:2841-2856(2001).
RN   [6]
RP   FUNCTION, INTERACTION WITH ARAC4/ROP2, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=18178769; DOI=10.1105/tpc.107.054544;
RA   Jeon B.W., Hwang J.U., Hwang Y., Song W.Y., Fu Y., Gu Y., Bao F., Cho D.,
RA   Kwak J.M., Yang Z., Lee Y.;
RT   "The Arabidopsis small G protein ROP2 is activated by light in guard cells
RT   and inhibits light-induced stomatal opening.";
RL   Plant Cell 20:75-87(2008).
CC   -!- FUNCTION: Functions as a downstream effector of Rho-related GTP binding
CC       proteins of the 'Rho of Plants' (ROPs) family. Participates in the
CC       propagation of ROP GTPase signals in specific cellular responses.
CC       Functions as a downstream effector of active ARAC4/ROP2 GTPase which is
CC       involved in the prevention of excessive stomatal opening upon light
CC       stimulation. Is involved in pollen tube growth regulation through its
CC       interaction with ARAC11/ROP1. {ECO:0000269|PubMed:11752391,
CC       ECO:0000269|PubMed:18178769}.
CC   -!- SUBUNIT: Interacts with ARAC4/ROP2 and ARAC11/ROP1.
CC       {ECO:0000269|PubMed:11752391, ECO:0000269|PubMed:18178769}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18178769}. Cytoplasm
CC       {ECO:0000269|PubMed:11752391, ECO:0000269|PubMed:18178769}. Cell
CC       membrane {ECO:0000269|PubMed:11752391, ECO:0000269|PubMed:18178769};
CC       Peripheral membrane protein {ECO:0000305}. Note=In guard cells in the
CC       dark localizes predominantly in the nucleus, but upon light
CC       irradiation, it is found at the plasma membrane and in the cytoplasm.
CC       {ECO:0000269|PubMed:18178769}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, guard cells, stems,
CC       flowers, siliques and pollen. {ECO:0000269|PubMed:11752391,
CC       ECO:0000269|PubMed:18178769}.
CC   -!- MISCELLANEOUS: Over-expression of RIC7 in tobacco germinating pollen
CC       reduces pollen tube elongation. {ECO:0000305|PubMed:11752391}.
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DR   EMBL; AL021749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002687; AEE85505.1; -; Genomic_DNA.
DR   EMBL; OZ408686; CAO7049078.1; -; Genomic_DNA.
DR   EMBL; DQ487576; ABF59238.1; -; mRNA.
DR   RefSeq; NP_001031740.1; NM_001036663.2.
DR   AlphaFoldDB; Q1G3K8; -.
DR   FunCoup; Q1G3K8; 74.
DR   PaxDb; 3702-Q1G3K8; -.
DR   ProteomicsDB; 236985; -.
DR   GeneID; 3770548; -.
DR   KEGG; ath:AT4G28556; -.
DR   Araport; AT4G28556; -.
DR   TAIR; AT4G28556; RIC7.
DR   eggNOG; ENOG502S2ZY; Eukaryota.
DR   HOGENOM; CLU_086489_2_0_1; -.
DR   InParanoid; Q1G3K8; -.
DR   OMA; ANIGWDG; -.
DR   PhylomeDB; Q1G3K8; -.
DR   PRO; PR:Q1G3K8; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q1G3K8; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; EXP:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0009416; P:response to light stimulus; IDA:TAIR.
DR   CDD; cd00132; CRIB; 1.
DR   FunFam; 3.90.810.10:FF:000029; Elongation factor Ts, mitochondrial; 1.
DR   Gene3D; 3.90.810.10; CRIB domain; 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   PANTHER; PTHR46325:SF9; CRIB DOMAIN-CONTAINING PROTEIN RIC6-RELATED; 1.
DR   PANTHER; PTHR46325; CRIB DOMAIN-CONTAINING PROTEIN RIC8; 1.
DR   Pfam; PF00786; PBD; 1.
DR   SMART; SM00285; PBD; 1.
DR   PROSITE; PS50108; CRIB; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cytoplasm; Growth regulation; Membrane; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..216
FT                   /note="CRIB domain-containing protein RIC7"
FT                   /id="PRO_0000422730"
FT   DOMAIN          36..49
FT                   /note="CRIB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00057"
FT   REGION          52..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  23754 MW;  73293B11CA48BA5F CRC64;
     MQLGMSSTKM KSLLKGLRYI SQVFAIEGEK EEEMQIGNPT DVKHVAHIGW DGPSDNATAP
     SWMNDFKSSP VMESIQGLGE DDSSVKCQSE FGGRTRDLPK LPKSTRKSSS EKGSPTKERS
     DKTKRRTSNK GTSSSRRTKD EDSTSSSRRT TKDEDSSLSQ HSAGLPEVPK KSKRKKSKEA
     GNGGSSRSSR ISEADYMSDT GSDRSMPQFE DDRNGF
//