{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q197F6","uniProtkbId":"VF067_IIV3","entryAudit":{"firstPublicDate":"2009-06-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-07-11","entryVersion":42,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Invertebrate iridescent virus 3","commonName":"IIV-3","synonyms":["Mosquito iridescent virus"],"taxonId":345201,"lineage":["Viruses","Varidnaviria","Bamfordvirae","Nucleocytoviricota","Megaviricetes","Pimascovirales","Pimascovirales incertae sedis","Iridoviridae","Betairidovirinae","Chloriridovirus","Chloriridovirus aedes1"]},"organismHosts":[{"scientificName":"Aedes vexans","commonName":"Inland floodwater mosquito","synonyms":["Culex vexans"],"taxonId":7163},{"scientificName":"Culex territans","taxonId":42431},{"scientificName":"Culiseta annulata","taxonId":332058},{"scientificName":"Ochlerotatus sollicitans","commonName":"eastern saltmarsh mosquito","taxonId":310513},{"scientificName":"Ochlerotatus taeniorhynchus","commonName":"Black salt marsh mosquito","synonyms":["Aedes taeniorhynchus"],"taxonId":329105},{"scientificName":"Psorophora ferox","taxonId":7183}],"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein 004R"}}},"genes":[{"orfNames":[{"value":"IIV3-004R"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the IIV-6 067R family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Uncharacterized protein 004R","featureId":"PRO_0000377760"},{"type":"Transmembrane","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16912294","citationType":"journal article","authors":["Delhon G.","Tulman E.R.","Afonso C.L.","Lu Z.","Becnel J.J.","Moser B.A.","Kutish G.F.","Rock D.L."],"citationCrossReferences":[{"database":"PubMed","id":"16912294"},{"database":"DOI","id":"10.1128/jvi.00464-06"}],"title":"Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus).","publicationDate":"2006","journal":"J. Virol.","firstPage":"8439","lastPage":"8449","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ643392","properties":[{"key":"ProteinId","value":"ABF82034.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_654576.1","properties":[{"key":"NucleotideSequenceId","value":"NC_008187.1"}]},{"database":"AlphaFoldDB","id":"Q197F6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"4156253","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"vg:4156253","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10549at10239","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001358","properties":[{"key":"Component","value":"Segment"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR043910","properties":[{"key":"EntryName","value":"DUF5767"}]},{"database":"Pfam","id":"PF19071","properties":[{"key":"EntryName","value":"DUF5767"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPPKNNQITYNIFKVDHRFALPRVRPKFPKFSELYLELLVNRSKVDPQLMNEPYVHRYDPVVSSGESMVNPVPPADDGRMVATTLKAVPRLSSVPNPSPAKPTQKPTISRESFVWESSASIDPSPRVQKKSRGRPASSTPSIEPESISRYRQVKRSIISSYYKQVGEGAPSTTRRAADSENERRPSEVREAPESRRRRETSETGSDKSKAPPPIKEIKKTFGNEENPLINVFEDYPQAKDEDDHKRELLFKFKRLRQTYPKVDIPDFTMLSNHETMKRTYDSTLRNLSIDSTVENYKSYLMMGFMACEMVLGKIGFDMEGYTQQQTLHMNKYEKLLVELGEKSYVPNSVNKWPVEVRLIGLMLFQTTIFIISKIIAKKTNVNLLQIYNNFSGLNEPPKVTRNGSSSGFASGTSSPLVFIPRTKRPSLVPSEKKMRGPSVTRDLAAEQERDA","length":451,"molWeight":51330,"crc64":"BE37D57472448194","md5":"F0937C6188C26D092964F48B2731AEB0"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Region":3,"Compositional bias":4},"uniParcId":"UPI0000D83466"}}