{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q15726","secondaryAccessions":["A8K6N0","Q9HBP1"],"uniProtkbId":"KISS1_HUMAN","entryAudit":{"firstPublicDate":"1999-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-03-23","entryVersion":187,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Metastasis-suppressor KiSS-1"}},"alternativeNames":[{"fullName":{"value":"Kisspeptin-1"}}],"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11385580"}],"value":"Metastin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11457843"}],"value":"Kisspeptin-54"}}]},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11457843"}],"value":"Kisspeptin-14"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11457843"}],"value":"Kisspeptin-13"}}},{"recommendedName":{"fullName":{"value":"Kisspeptin-10"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"KISS1"},"orfNames":[{"value":"PP5098"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6Y4S4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11385580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11457843"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11527393"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12879005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15020672"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15219839"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15596153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15598687"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22335740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25147978"}],"value":"Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54 (PubMed:11385580, PubMed:11457843, PubMed:11527393, PubMed:12879005, PubMed:15020672, PubMed:15596153). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15219839, PubMed:15598687, PubMed:22335740). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:15598687, PubMed:22335740). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (By similarity). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (PubMed:25147978). Kisspeptins are also involved in the regulation of other processes including cell growth, cell proliferation and cell migration (PubMed:11385580, PubMed:11457843, PubMed:11527393, PubMed:12879005, PubMed:15020672, PubMed:15596153)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6Y4S4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11457843"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15020672"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22335740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25147978"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38512807"}],"value":"Binds the G protein-coupled receptor KISS1R/GPR54 and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C (PubMed:11457843, PubMed:22335740). Binding to the receptor also activates beta-arrestin-dependent signaling resulting in ERK1/2 phosphorylation (PubMed:11457843, PubMed:25147978). Activation of the receptor inhibits cell proliferation and cell migration, and is involved in the regulation of trophoblast invasion during early stages of pregnancy. Is also involved in the modulation of airway smooth muscle cells migration (PubMed:11457843, PubMed:15020672, PubMed:38512807). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity)"}],"commentType":"FUNCTION","molecule":"Kisspeptin-10"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39151001"}],"value":"Receptor binding triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C"}],"commentType":"FUNCTION","molecule":"Metastin"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q15726","intActId":"EBI-23759979"},"interactantTwo":{"uniProtKBAccession":"Q9UHD9","geneName":"UBQLN2","intActId":"EBI-947187"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15020672"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11385580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11457843"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12414911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15020672"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8944003"}],"value":"High expression in placenta (PubMed:8944003, PubMed:11385580, PubMed:11457843, PubMed:12574233). Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. In first trimester trophoblasts is expressed at higher levels than at term of gestation, but only expressed in the villous trophoblast (PubMed:15020672). Also expressed in testis, pancreas, liver, small intestine"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12879005"}],"value":"Processed by MMP2 and MMP9"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Hypogonadotropic hypogonadism 13 with or without anosmia","diseaseAccession":"DI-03573","acronym":"HH13","description":"A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).","diseaseCrossReference":{"database":"MIM","id":"614842"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22335740"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8944003"}],"value":"Was originally identified as a metastasis suppressor gene"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the KISS1 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/058","ftp":false,"note":"Tintin's blight - Issue 58 of May 2005"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Metastasis-suppressor KiSS-1","featureId":"PRO_0000021544"},{"type":"Peptide","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Metastin","featureId":"PRO_0000021545"},{"type":"Peptide","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Kisspeptin-14","featureId":"PRO_0000021546"},{"type":"Peptide","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Kisspeptin-13","featureId":"PRO_0000021547"},{"type":"Peptide","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Kisspeptin-10","featureId":"PRO_0000021548"},{"type":"Region","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Essential for receptor binding and receptor activation"},{"type":"Region","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Cleavage; by MMP2 and MMP9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12879005"}]},{"type":"Modified residue","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"15144186"}]},{"type":"Modified residue","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Phenylalanine amide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11385580"}]},{"type":"Natural variant","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"in dbSNP:rs12998","featureCrossReferences":[{"database":"dbSNP","id":"rs12998"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15598687"}],"featureId":"VAR_021396","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"in dbSNP:rs35431622","featureCrossReferences":[{"database":"dbSNP","id":"rs35431622"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15598687"}],"featureId":"VAR_021397","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"in dbSNP:rs4889","featureCrossReferences":[{"database":"dbSNP","id":"rs4889"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15598687"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8944003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9806840"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_021398","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"in HH13; likely pathogenic; severely decreased receptor ligand activity; reduced phospholipase C-activating G protein-coupled receptor signaling","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22335740"}],"featureId":"VAR_069179","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in dbSNP:rs1429366684","featureCrossReferences":[{"database":"dbSNP","id":"rs1429366684"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8944003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9806840"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_091089","alternativeSequence":{"originalSequence":"G","alternativeSequences":["GWGAGAGQ"]}},{"type":"Helix","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ZJD"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1016","category":"Disease","name":"Hypogonadotropic hypogonadism"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"8944003","citationType":"journal article","authors":["Lee J.-H.","Miele M.E.","Hicks D.J.","Phillips K.K.","Trent J.M.","Weissman B.E.","Welch D.R."],"citationCrossReferences":[{"database":"PubMed","id":"8944003"},{"database":"DOI","id":"10.1093/jnci/88.23.1731"}],"title":"KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.","publicationDate":"1996","journal":"J. Natl. Cancer Inst.","firstPage":"1731","lastPage":"1737","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","VARIANTS ARG-81 AND TRP-GLY-ALA-GLY-ALA-GLY-GLN-138 EXT"]},{"referenceNumber":2,"citation":{"id":"CI-CASKPUQN59KU","citationType":"journal article","authors":["Lee J.-H.","Miele M.E.","Hicks D.J.","Phillips K.K.","Trent J.M.","Weissman B.E.","Welch D.R."],"publicationDate":"1997","journal":"J. Natl. Cancer Inst.","firstPage":"1549","lastPage":"1549","volume":"89"},"referencePositions":["ERRATUM OF PUBMED:8944003"]},{"referenceNumber":3,"citation":{"id":"9806840","citationType":"journal article","authors":["West A.","Vojta P.J.","Welch D.R.","Weissman B.E."],"citationCrossReferences":[{"database":"PubMed","id":"9806840"},{"database":"DOI","id":"10.1006/geno.1998.5566"}],"title":"Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1).","publicationDate":"1998","journal":"Genomics","firstPage":"145","lastPage":"148","volume":"54"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANTS ARG-81 AND TRP-GLY-ALA-GLY-ALA-GLY-GLN-138 EXT"]},{"referenceNumber":4,"citation":{"id":"CI-26B69EKK6GM8S","citationType":"submission","authors":["Qiao C.","Lin Q.D.","Xu W.X.","He Y.","Wang C.H."],"title":"Cloned KiSS-1 gene from human term placenta.","publicationDate":"JUN-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANTS ARG-81 AND TRP-GLY-ALA-GLY-ALA-GLY-GLN-138 EXT"],"referenceComments":[{"value":"Term placenta","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15498874","citationType":"journal article","authors":["Wan D.","Gong Y.","Qin W.","Zhang P.","Li J.","Wei L.","Zhou X.","Li H.","Qiu X.","Zhong F.","He L.","Yu J.","Yao G.","Jiang H.","Qian L.","Yu Y.","Shu H.","Chen X.","Xu H.","Guo M.","Pan Z.","Chen Y.","Ge C.","Yang S.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"15498874"},{"database":"DOI","id":"10.1073/pnas.0404089101"}],"title":"Large-scale cDNA transfection screening for genes related to cancer development and progression.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15724","lastPage":"15729","volume":"101"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"11385580","citationType":"journal article","authors":["Ohtaki T.","Shintani Y.","Honda S.","Matsumoto H.","Hori A.","Kanehashi K.","Terao Y.","Kumano S.","Takatsu Y.","Masuda Y.","Ishibashi Y.","Watanabe T.","Asada M.","Yamada T.","Suenaga M.","Kitada C.","Usuki S.","Kurokawa T.","Onda H.","Nishimura O.","Fujino M."],"citationCrossReferences":[{"database":"PubMed","id":"11385580"},{"database":"DOI","id":"10.1038/35079135"}],"title":"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.","publicationDate":"2001","journal":"Nature","firstPage":"613","lastPage":"617","volume":"411"},"referencePositions":["PROTEIN SEQUENCE OF 68-88","AMIDATION AT PHE-121","FUNCTION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"11457843","citationType":"journal article","authors":["Kotani M.","Detheux M.","Vandenbogaerde A.","Communi D.","Vanderwinden J.-M.","Le Poul E.","Brezillon S.","Tyldesley R.","Suarez-Huerta N.","Vandeput F.","Blanpain C.","Schiffmann S.N.","Vassart G.","Parmentier M."],"citationCrossReferences":[{"database":"PubMed","id":"11457843"},{"database":"DOI","id":"10.1074/jbc.m104847200"}],"title":"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"34631","lastPage":"34636","volume":"276"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","MASS SPECTROMETRY"]},{"referenceNumber":11,"citation":{"id":"11527393","citationType":"journal article","authors":["Hori A.","Honda S.","Asada M.","Ohtaki T.","Oda K.","Watanabe T.","Shintani Y.","Yamada T.","Suenaga M.","Kitada C.","Onda H.","Kurokawa T.","Nishimura O.","Fujino M."],"citationCrossReferences":[{"database":"PubMed","id":"11527393"},{"database":"DOI","id":"10.1006/bbrc.2001.5470"}],"title":"Metastin suppresses the motility and growth of CHO cells transfected with its receptor.","publicationDate":"2001","journal":"Biochem. Biophys. Res. Commun.","firstPage":"958","lastPage":"963","volume":"286"},"referencePositions":["FUNCTION"]},{"referenceNumber":12,"citation":{"id":"12414911","citationType":"journal article","authors":["Janneau J.-L.","Maldonado-Estrada J.","Tachdjian G.","Miran I.","Motte N.","Saulnier P.","Sabourin J.-C.","Cote J.-F.","Simon B.","Frydman R.","Chaouat G.","Bellet D."],"citationCrossReferences":[{"database":"PubMed","id":"12414911"},{"database":"DOI","id":"10.1210/jc.2002-021093"}],"title":"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.","publicationDate":"2002","journal":"J. Clin. Endocrinol. Metab.","firstPage":"5336","lastPage":"5339","volume":"87"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":13,"citation":{"id":"12574233","citationType":"journal article","authors":["Horikoshi Y.","Matsumoto H.","Takatsu Y.","Ohtaki T.","Kitada C.","Usuki S.","Fujino M."],"citationCrossReferences":[{"database":"PubMed","id":"12574233"},{"database":"DOI","id":"10.1210/jc.2002-021235"}],"title":"Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans.","publicationDate":"2003","journal":"J. Clin. Endocrinol. Metab.","firstPage":"914","lastPage":"919","volume":"88"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":14,"citation":{"id":"12879005","citationType":"journal article","authors":["Takino T.","Koshikawa N.","Miyamori H.","Tanaka M.","Sasaki T.","Okada Y.","Seiki M.","Sato H."],"citationCrossReferences":[{"database":"PubMed","id":"12879005"},{"database":"DOI","id":"10.1038/sj.onc.1206542"}],"title":"Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.","publicationDate":"2003","journal":"Oncogene","firstPage":"4617","lastPage":"4626","volume":"22"},"referencePositions":["PROTEOLYTIC PROCESSING BY MMP2 AND MMP9","FUNCTION"]},{"referenceNumber":15,"citation":{"id":"15144186","citationType":"journal article","authors":["Brill L.M.","Salomon A.R.","Ficarro S.B.","Mukherji M.","Stettler-Gill M.","Peters E.C."],"citationCrossReferences":[{"database":"PubMed","id":"15144186"},{"database":"DOI","id":"10.1021/ac035352d"}],"title":"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.","publicationDate":"2004","journal":"Anal. Chem.","firstPage":"2763","lastPage":"2772","volume":"76"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-112","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"15020672","citationType":"journal article","authors":["Bilban M.","Ghaffari-Tabrizi N.","Hintermann E.","Bauer S.","Molzer S.","Zoratti C.","Malli R.","Sharabi A.","Hiden U.","Graier W.","Knoefler M.","Andreae F.","Wagner O.","Quaranta V.","Desoye G."],"citationCrossReferences":[{"database":"PubMed","id":"15020672"},{"database":"DOI","id":"10.1242/jcs.00971"}],"title":"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts.","publicationDate":"2004","journal":"J. Cell Sci.","firstPage":"1319","lastPage":"1328","volume":"117"},"referencePositions":["TISSUE SPECIFICITY","SUBCELLULAR LOCATION","FUNCTION"]},{"referenceNumber":17,"citation":{"id":"15219839","citationType":"journal article","authors":["Matsui H.","Takatsu Y.","Kumano S.","Matsumoto H.","Ohtaki T."],"citationCrossReferences":[{"database":"PubMed","id":"15219839"},{"database":"DOI","id":"10.1016/j.bbrc.2004.05.185"}],"title":"Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat.","publicationDate":"2004","journal":"Biochem. Biophys. Res. Commun.","firstPage":"383","lastPage":"388","volume":"320"},"referencePositions":["FUNCTION"]},{"referenceNumber":18,"citation":{"id":"15596153","citationType":"journal article","authors":["Becker J.A.J.","Mirjolet J.-F.","Bernard J.","Burgeon E.","Simons M.-J.","Vassart G.","Parmentier M.","Libert F."],"citationCrossReferences":[{"database":"PubMed","id":"15596153"},{"database":"DOI","id":"10.1016/j.bbrc.2004.11.094"}],"title":"Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors.","publicationDate":"2005","journal":"Biochem. Biophys. Res. Commun.","firstPage":"677","lastPage":"686","volume":"326"},"referencePositions":["FUNCTION"]},{"referenceNumber":19,"citation":{"id":"25147978","citationType":"journal article","authors":["Ahow M.","Min L.","Pampillo M.","Nash C.","Wen J.","Soltis K.","Carroll R.S.","Glidewell-Kenney C.A.","Mellon P.L.","Bhattacharya M.","Tobet S.A.","Kaiser U.B.","Babwah A.V."],"citationCrossReferences":[{"database":"PubMed","id":"25147978"},{"database":"DOI","id":"10.1210/en.2014-1304"}],"title":"KISS1R signals independently of Galphaq/11 and triggers LH secretion via the beta-arrestin pathway in the male mouse.","publicationDate":"2014","journal":"Endocrinology","firstPage":"4433","lastPage":"4446","volume":"155"},"referencePositions":["FUNCTION"]},{"referenceNumber":20,"citation":{"id":"38512807","citationType":"journal article","authors":["Balraj P.","Ambhore N.S.","Ramakrishnan Y.S.","Borkar N.A.","Banerjee P.","Reza M.I.","Varadharajan S.","Kumar A.","Pabelick C.M.","Prakash Y.S.","Sathish V."],"citationCrossReferences":[{"database":"PubMed","id":"38512807"},{"database":"DOI","id":"10.1165/rcmb.2023-0469oc"}],"title":"Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration.","publicationDate":"2024","journal":"Am. J. Respir. Cell Mol. Biol.","firstPage":"507","lastPage":"518","volume":"70"},"referencePositions":["FUNCTION (KISSPEPTIN-10)"]},{"referenceNumber":21,"citation":{"id":"38935498","citationType":"journal article","authors":["Shen S.","Wang D.","Liu H.","He X.","Cao Y.","Chen J.","Li S.","Cheng X.","Xu H.E.","Duan J."],"citationCrossReferences":[{"database":"PubMed","id":"38935498"},{"database":"DOI","id":"10.1016/j.celrep.2024.114389"}],"title":"Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.","publicationDate":"2024","journal":"Cell Rep.","firstPage":"114389","lastPage":"114389","volume":"43"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.06 ANGSTROMS) OF 112-121 IN COMPLEX WITH KISS1R AND G PROTEINS"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ZJD"}]},{"referenceNumber":22,"citation":{"id":"39151001","citationType":"journal article","authors":["Wu Z.","Chen G.","Qiu C.","Yan X.","Xu L.","Jiang S.","Xu J.","Han R.","Shi T.","Liu Y.","Gao W.","Wang Q.","Li J.","Ye F.","Pan X.","Zhang Z.","Ning P.","Zhang B.","Chen J.","Du Y."],"citationCrossReferences":[{"database":"PubMed","id":"39151001"},{"database":"DOI","id":"10.1126/sciadv.adn7771"}],"title":"Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor.","publicationDate":"2024","journal":"Sci. Adv.","firstPage":"eadn7771","lastPage":"eadn7771","volume":"10"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.95 ANGSTROMS) OF 68-121 IN COMPLEX WITH KISS1R; GNAQ; GNB1 AND GNG2","FUNCTION (METASTIN)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8XGS"}]},{"referenceNumber":23,"citation":{"id":"15598687","citationType":"journal article","authors":["Semple R.K.","Achermann J.C.","Ellery J.","Farooqi I.S.","Karet F.E.","Stanhope R.G.","O'rahilly S.","Aparicio S.A."],"citationCrossReferences":[{"database":"PubMed","id":"15598687"},{"database":"DOI","id":"10.1210/jc.2004-1418"}],"title":"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.","publicationDate":"2005","journal":"J. Clin. Endocrinol. Metab.","firstPage":"1849","lastPage":"1855","volume":"90"},"referencePositions":["VARIANTS LYS-20; ARG-36 AND ARG-81","FUNCTION"]},{"referenceNumber":24,"citation":{"id":"22335740","citationType":"journal article","authors":["Topaloglu A.K.","Tello J.A.","Kotan L.D.","Ozbek M.N.","Yilmaz M.B.","Erdogan S.","Gurbuz F.","Temiz F.","Millar R.P.","Yuksel B."],"citationCrossReferences":[{"database":"PubMed","id":"22335740"},{"database":"DOI","id":"10.1056/nejmoa1111184"}],"title":"Inactivating KISS1 mutation and hypogonadotropic hypogonadism.","publicationDate":"2012","journal":"N. Engl. J. Med.","firstPage":"629","lastPage":"635","volume":"366"},"referencePositions":["VARIANT HH13 LYS-115","CHARACTERIZATION OF VARIANT HH13 LYS-115","INVOLVEMENT IN HH13","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U43527","properties":[{"key":"ProteinId","value":"AAC79512.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY117143","properties":[{"key":"ProteinId","value":"AAM78592.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF218017","properties":[{"key":"ProteinId","value":"AAG17259.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL592114","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK291695","properties":[{"key":"ProteinId","value":"BAF84384.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC022819","properties":[{"key":"ProteinId","value":"AAH22819.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS41454.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_002247.3","properties":[{"key":"NucleotideSequenceId","value":"NM_002256.4"}]},{"database":"PDB","id":"8XGS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"F=68-121"}]},{"database":"PDB","id":"8ZJD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"L=112-121"}]},{"database":"PDBsum","id":"8XGS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ZJD","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38331","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60141","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"110014","properties":[{"key":"Interactions","value":"13"}]},{"database":"FunCoup","id":"Q15726","properties":[{"key":"Number of interactors","value":"384"}]},{"database":"IntAct","id":"Q15726","properties":[{"key":"Interactions","value":"9"}]},{"database":"NDEx","id":"IQUERY-CP-KISS1","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000356162","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB11975","properties":[{"key":"GenericName","value":"TAK-448"}]},{"database":"iPTMnet","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"KISS1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000356162","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"60723","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34554","properties":[{"key":"antibodies","value":"324 antibodies from 33 providers"}]},{"database":"DNASU","id":"3814","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000367194.5","properties":[{"key":"ProteinId","value":"ENSP00000356162.4"},{"key":"GeneId","value":"ENSG00000170498.11"}]},{"database":"Ensembl","id":"ENST00000882445.1","properties":[{"key":"ProteinId","value":"ENSP00000552504.1"},{"key":"GeneId","value":"ENSG00000170498.11"}]},{"database":"GeneID","id":"3814","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3814","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000367194.5","properties":[{"key":"ProteinId","value":"ENSP00000356162.4"},{"key":"RefSeqNucleotideId","value":"NM_002256.4"},{"key":"RefSeqProteinId","value":"NP_002247.3"}]},{"database":"UCSC","id":"uc001har.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:6341","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30127","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3814","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3814","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"KISS1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"KISS1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:6341","properties":[{"key":"GeneName","value":"KISS1"}]},{"database":"HPA","id":"ENSG00000170498","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (placenta)"}]},{"database":"MalaCards","id":"KISS1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"603286","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"614842","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000170498","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"650097","properties":[{"key":"Disease","value":"Genetic central precocious puberty in male"}]},{"database":"Orphanet","id":"432","properties":[{"key":"Disease","value":"Normosmic congenital hypogonadotropic hypogonadism"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000170498","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SFM2","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000008827","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_119112_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LAHLIPW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9899812at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q15726","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-HSA-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}]},{"database":"SignaLink","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000170498","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3814","properties":[{"key":"hits","value":"37 hits in 1142 CRISPR screens"}]},{"database":"ChiTaRS","id":"KISS1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Kisspeptin","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3814","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q15726","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q15726","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q15726","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000170498","properties":[{"key":"ExpressionPatterns","value":"Expressed in placenta and 77 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15020672"}]},{"database":"GO","id":"GO:0031773","properties":[{"key":"GoTerm","value":"F:kisspeptin receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007010","properties":[{"key":"GoTerm","value":"P:cytoskeleton organization"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9192814"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045779","properties":[{"key":"GoTerm","value":"P:negative regulation of bone resorption"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033686","properties":[{"key":"GoTerm","value":"P:positive regulation of luteinizing hormone secretion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"DisProt","id":"DP01173","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR020207","properties":[{"key":"EntryName","value":"Metastasis-suppressor_KiSS-1"}]},{"database":"PANTHER","id":"PTHR16955","properties":[{"key":"EntryName","value":"METASTASIS-SUPPRESSOR KISS-1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16955:SF6","properties":[{"key":"EntryName","value":"METASTASIS-SUPPRESSOR KISS-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15152","properties":[{"key":"EntryName","value":"Kisspeptin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNSLVSWQLLLFLCATHFGEPLEKVASVGNSRPTGQQLESLGLLAPGEQSLPCTERKPAATARLSRRGTSLSPPPESSGSPQQPGLSAPHSRQIPAPQGAVLVQREKDLPNYNWNSFGLRFGKREAAPGNHGRSAGRG","length":138,"molWeight":14705,"crc64":"0F0A1E1D66EDC22A","md5":"91DD01CE3A69E71FB032D8C2374EA18F"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1,"DISEASE":1,"MISCELLANEOUS":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Peptide":4,"Region":3,"Compositional bias":2,"Site":1,"Modified residue":2,"Natural variant":5,"Helix":1},"uniParcId":"UPI000007059D"}}