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May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454579"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12077347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12390891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20873783"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25219498"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26924529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31799605"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32099016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32579943"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36302773"}],"value":"Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (PubMed:10454579). 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Interacts with ZCCHC4 (PubMed:31799605)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10454579"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20873783"}],"value":"Cytoplasmic under conditions of serum deprivation (PubMed:10454579). 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