{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q15326","secondaryAccessions":["B2R6G8","B7Z293","F6UH50","Q2LD45","Q2LD46","Q2LD47","Q2LD48","Q5VUI1","Q8N4B3"],"uniProtkbId":"ZMY11_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-11-28","entryVersion":212,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Zinc finger MYND domain-containing protein 11"}},"alternativeNames":[{"fullName":{"value":"Adenovirus 5 E1A-binding protein"}},{"fullName":{"value":"Bone morphogenetic protein receptor-associated molecule 1"}},{"fullName":{"value":"Protein BS69"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16966"}],"value":"ZMYND11"},"synonyms":[{"value":"BRAM1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24675531"}],"value":"BS69"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8R5C8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10734313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16565076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24675531"}],"value":"Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845565"}],"value":"(Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10734313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15947784"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16565076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19766626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23372760"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24675531"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845565"}],"value":"Homooligomer; forms homooligomers via its C-terminus (PubMed:26845565). Interacts with histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) (PubMed:24675531, PubMed:26655721). Interacts (via MYND-type zinc finger) with NCOR1 (PubMed:10734313). Interacts (via MYND-type zinc finger) with MGA protein (via PXLXP motif) (PubMed:23372760). Interacts (via MYND-type zinc finger) with EZH2 (PubMed:16565076). Interacts with EMSY and E2F6 (PubMed:15947784, PubMed:16565076). Interacts with PIAS1 and UBE2I (PubMed:19766626)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11733528"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23372760"}],"value":"(Microbial infection) Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11733528"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12181323"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16382137"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19379743"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20138174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26845565"}],"value":"(Microbial infection) Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif) (PubMed:11733528, PubMed:26845565). Interacts with Epstein-Barr virus-derived protein LMP1; leading to negatively regulate NF-kappa-B activation by Epstein-Barr virus-derived protein LMP1 (PubMed:12181323, PubMed:16382137, PubMed:19379743, PubMed:20138174)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q15326","intActId":"EBI-2623509"},"interactantTwo":{"uniProtKBAccession":"P36941","geneName":"LTBR","intActId":"EBI-3509981"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15326","intActId":"EBI-2623509"},"interactantTwo":{"uniProtKBAccession":"Q13114","geneName":"TRAF3","intActId":"EBI-357631"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15326","intActId":"EBI-2623509"},"interactantTwo":{"uniProtKBAccession":"Q9UKY1","geneName":"ZHX1","intActId":"EBI-347767"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15326","intActId":"EBI-2623509"},"interactantTwo":{"uniProtKBAccession":"P12978","geneName":"EBNA2","intActId":"EBI-8052923"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q15326","intActId":"EBI-2623509"},"interactantTwo":{"uniProtKBAccession":"P03230","geneName":"LMP1","intActId":"EBI-6973030"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q15326","intActId":"EBI-2623509"},"interactantTwo":{"uniProtKBAccession":"P03255","intActId":"EBI-2603114"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16565076"}],"value":"Associates with chromatin and mitotic chromosomes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16565076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19766626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24675531"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25593309"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16565076"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q15326-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q15326-2"],"sequenceIds":["VSP_044482"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q15326-3"],"sequenceIds":["VSP_044483"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q15326-4"],"sequenceIds":["VSP_044482","VSP_044483"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q15326-5"],"sequenceIds":["VSP_044482","VSP_046246"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q15326-6"],"sequenceIds":["VSP_047209","VSP_044483"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16565076"}],"value":"Ubiquitous"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24590075"}],"value":"Down-regulated in breast cancer patients with poor prognosis"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24675531"}],"value":"The PWWP domain specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and adopts a five-bladed beta-barrel fold with an extended C-terminal alpha-helix, with a conserved H3.3K36me3-binding aromatic cage formed by Phe-291 and Trp-294 of the beta1-beta2 loop and Phe-310 of the beta3-beta4 loop. Specific recognition of H3.3 histone is mediated by the encapsulation of the H3.3-specific 'Ser 31' residue in a composite pocket formed by the tandem bromo-PWWP domains"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19766626"}],"value":"Sumoylated following its interaction with PIAS1 and UBE2I"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16565076"}],"value":"Ubiquitinated, leading to proteasomal degradation"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23915195"}],"value":"A chromosomal aberration involving ZMYND11 is a cause of acute poorly differentiated myeloid leukemia. 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