ID   PGFRL_HUMAN             Reviewed;         375 AA.
AC   Q15198; A8K085; Q6FH04;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 180.
DE   RecName: Full=Platelet-derived growth factor receptor-like protein;
DE            Short=PDGFR-like protein;
DE   AltName: Full=PDGF receptor beta-like tumor suppressor;
DE   Flags: Precursor;
GN   Name=PDGFRL; Synonyms=PRLTS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], VARIANT CRC TYR-23, AND TISSUE SPECIFICITY.
RC   TISSUE=Fetal lung;
RX   PubMed=7898930;
RA   Fujiwara Y., Ohata H., Kuroki T., Koyama K., Tsuchiya E., Monden M.,
RA   Nakamura Y.;
RT   "Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22
RT   that is homologous to an extracellular domain of the PDGF receptor beta
RT   gene.";
RL   Oncogene 10:891-895(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Urinary bladder;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH GRB2 AND TNK2.
RX   PubMed=19815557; DOI=10.1074/jbc.m109.072660;
RA   Pao-Chun L., Chan P.M., Chan W., Manser E.;
RT   "Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is
RT   mediated by Grb2: an analysis of ACK1 effects on Axl signaling.";
RL   J. Biol. Chem. 284:34954-34963(2009).
RN   [7]
RP   POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO BEHCET DISEASE.
RX   PubMed=22926996; DOI=10.1002/humu.22208;
RA   Hou S., Xiao X., Zhou Y., Zhu X., Li F., Kijlstra A., Yang P.;
RT   "Genetic variant on PDGFRL associated with Behcet disease in Chinese Han
RT   populations.";
RL   Hum. Mutat. 34:74-78(2013).
CC   -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in colon, lung and liver.
CC       {ECO:0000269|PubMed:7898930}.
CC   -!- DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease
CC       characterized by malignant lesions arising from the inner wall of the
CC       large intestine (the colon) and the rectum. Genetic alterations are
CC       often associated with progression from premalignant lesion (adenoma) to
CC       invasive adenocarcinoma. Risk factors for cancer of the colon and
CC       rectum include colon polyps, long-standing ulcerative colitis, and
CC       genetic family history. {ECO:0000269|PubMed:7898930}. Note=The gene
CC       represented in this entry is involved in disease pathogenesis.
CC   -!- DISEASE: Note=A polymorphism in PDGFRL has been reported to be
CC       associated with susceptibility to Behcet disease (PubMed:22926996).
CC       Behcet disease is a complex multiple-system disorder characterized by
CC       recurrent oral ulcerations, recurrent genital ulcerations, typical skin
CC       lesions, and uveitis. Behcet disease also involves joints, blood
CC       vessels, musculoskeletal, neurological systems, and the
CC       gastrointestinal tract. {ECO:0000269|PubMed:22926996}.
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DR   EMBL; D37965; BAA07179.1; -; mRNA.
DR   EMBL; CR541952; CAG46750.1; -; mRNA.
DR   EMBL; AK289450; BAF82139.1; -; mRNA.
DR   EMBL; CH471080; EAW63811.1; -; Genomic_DNA.
DR   EMBL; BC010927; AAH10927.1; -; mRNA.
DR   CCDS; CCDS6003.1; -.
DR   PIR; I60125; I60125.
DR   RefSeq; NP_006198.1; NM_006207.2.
DR   AlphaFoldDB; Q15198; -.
DR   BioGRID; 111183; 43.
DR   IntAct; Q15198; 24.
DR   MINT; Q15198; -.
DR   STRING; 9606.ENSP00000444211; -.
DR   TCDB; 8.A.23.1.55; the basigin (basigin) family.
DR   GlyConnect; 1609; 3 N-Linked glycans (1 site).
DR   GlyCosmos; Q15198; 2 sites, 2 glycans.
DR   GlyGen; Q15198; 2 sites, 2 N-linked glycans (1 site).
DR   iPTMnet; Q15198; -.
DR   PhosphoSitePlus; Q15198; -.
DR   BioMuta; PDGFRL; -.
DR   DMDM; 74762141; -.
DR   jPOST; Q15198; -.
DR   MassIVE; Q15198; -.
DR   PaxDb; 9606-ENSP00000444211; -.
DR   PeptideAtlas; Q15198; -.
DR   ProteomicsDB; 60488; -.
DR   Antibodypedia; 22286; 274 antibodies from 31 providers.
DR   DNASU; 5157; -.
DR   Ensembl; ENST00000251630.11; ENSP00000251630.4; ENSG00000104213.13.
DR   Ensembl; ENST00000541323.1; ENSP00000444211.1; ENSG00000104213.13.
DR   GeneID; 5157; -.
DR   KEGG; hsa:5157; -.
DR   MANE-Select; ENST00000251630.11; ENSP00000251630.4; NM_001372073.1; NP_001359002.1.
DR   UCSC; uc003wxr.3; human.
DR   AGR; HGNC:8805; -.
DR   CTD; 5157; -.
DR   DisGeNET; 5157; -.
DR   GeneCards; PDGFRL; -.
DR   HGNC; HGNC:8805; PDGFRL.
DR   HPA; ENSG00000104213; Tissue enhanced (ovary).
DR   MalaCards; PDGFRL; -.
DR   MIM; 114500; phenotype.
DR   MIM; 604584; gene.
DR   neXtProt; NX_Q15198; -.
DR   OpenTargets; ENSG00000104213; -.
DR   Orphanet; 210159; Adult hepatocellular carcinoma.
DR   PharmGKB; PA33149; -.
DR   VEuPathDB; HostDB:ENSG00000104213; -.
DR   eggNOG; KOG0200; Eukaryota.
DR   GeneTree; ENSGT00390000017153; -.
DR   HOGENOM; CLU_062833_0_0_1; -.
DR   InParanoid; Q15198; -.
DR   OMA; GNKIEWS; -.
DR   OrthoDB; 3035719at2759; -.
DR   PhylomeDB; Q15198; -.
DR   TreeFam; TF334735; -.
DR   PathwayCommons; Q15198; -.
DR   SignaLink; Q15198; -.
DR   BioGRID-ORCS; 5157; 10 hits in 1152 CRISPR screens.
DR   ChiTaRS; PDGFRL; human.
DR   GenomeRNAi; 5157; -.
DR   Pharos; Q15198; Tbio.
DR   PRO; PR:Q15198; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q15198; Protein.
DR   Bgee; ENSG00000104213; Expressed in pericardium and 166 other cell types or tissues.
DR   ExpressionAtlas; Q15198; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
DR   GO; GO:0005019; F:platelet-derived growth factor beta-receptor activity; TAS:ProtInc.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR042495; PDGFRL.
DR   PANTHER; PTHR15360; PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE; 1.
DR   PANTHER; PTHR15360:SF1; PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   Pfam; PF21339; VEGFR-1-like_Ig-like; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   Genevisible; Q15198; HS.
PE   1: Evidence at protein level;
KW   Disease variant; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..375
FT                   /note="Platelet-derived growth factor receptor-like
FT                   protein"
FT                   /id="PRO_0000233090"
FT   DOMAIN          62..159
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          272..375
FT                   /note="Ig-like C2-type 2"
FT   REGION          22..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        219
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..143
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        293..357
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VARIANT         23
FT                   /note="H -> Y (in CRC; somatic mutation;
FT                   dbSNP:rs137853148)"
FT                   /evidence="ECO:0000269|PubMed:7898930"
FT                   /id="VAR_026052"
FT   CONFLICT        227
FT                   /note="M -> I (in Ref. 2; CAG46750)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   375 AA;  41861 MW;  DF7FE6EB3FB2A802 CRC64;
     MKVWLLLGLL LVHEALEDVT GQHLPKNKRP KEPGENRIKP TNKKVKPKIP KMKDRDSANS
     APKTQSIMMQ VLDKGRFQKP AATLSLLAGQ TVELRCKGSR IGWSYPAYLD TFKDSRLSVK
     QNERYGQLTL VNSTSADTGE FSCWVQLCSG YICRKDEAKT GSTYIFFTEK GELFVPSPSY
     FDVVYLNPDR QAVVPCRVTV LSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSEH
     QGVVYCRAEA GGRSQISVKY QLLYVAVPSG PPSTTILASS NKVKSGDDIS VLCTVLGEPD
     VEVEFTWIFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VITVEDFETI DAGYYICTAQ
     NLQGQTTVAT TVEFS
//