{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q15013","secondaryAccessions":["B4DLV3","E9PAT7","Q6IBB1"],"uniProtkbId":"MD2BP_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":177,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"MAD2L1-binding protein"}},"alternativeNames":[{"fullName":{"value":"Caught by MAD2 protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18022368"}],"value":"p31(comet)"}}]},"genes":[{"geneName":{"value":"MAD2L1BP"},"synonyms":[{"value":"CMT2"},{"value":"KIAA0110"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18022368"}],"value":"May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12456649"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18022368"}],"value":"Interacts with MAD2L1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"Q8TC99","geneName":"FNDC8","intActId":"EBI-12903902"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"Q8IX15-3","geneName":"HOMEZ","intActId":"EBI-10172004"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"Q9BT40","geneName":"INPP5K","intActId":"EBI-749162"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"Q13257","geneName":"MAD2L1","intActId":"EBI-78203"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"Q13287","geneName":"NMI","intActId":"EBI-372942"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"Q562F6","geneName":"SGO2","intActId":"EBI-989213"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"Q15645","geneName":"TRIP13","intActId":"EBI-358993"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"O43829","geneName":"ZBTB14","intActId":"EBI-10176632"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q15013","intActId":"EBI-712181"},"interactantTwo":{"uniProtKBAccession":"O95125","geneName":"ZNF202","intActId":"EBI-751960"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q15013-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q15013-3"],"sequenceIds":["VSP_046268"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12456649"}],"value":"During the cell cycle, levels increase and then remain constant until late mitosis after which they drop"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MAD2L1BP family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAG59665.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"MAD2L1-binding protein","featureId":"PRO_0000096310"},{"type":"Region","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Interaction with MAD2L1"},{"type":"Modified residue","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"}],"featureId":"VSP_046268","alternativeSequence":{"originalSequence":"MAAPEAEVLSSAAVP","alternativeSequences":["MARVPLGRSLTLSPRLEHNGMTSAHHNFRLPGSRDSPASASQVAEII"]}},{"type":"Mutagenesis","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Loss of interaction with MAD2L1 and disruption of ability to overcome spindle checkpoint-dependent mitotic arrest; when associated with A-191.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18022368"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Loss of interaction with MAD2L1 and disruption of ability to overcome spindle checkpoint-dependent mitotic arrest; when associated with A-83.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18022368"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in Ref. 2; BAG59665","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"in Ref. 3; CAG33174","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Helix","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Helix","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Helix","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Turn","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Helix","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Turn","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2QYF"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"7788527","citationType":"journal article","authors":["Nagase T.","Miyajima N.","Tanaka A.","Sazuka T.","Seki N.","Sato S.","Tabata S.","Ishikawa K.","Kawarabayasi Y.","Kotani H.","Nomura N."],"citationCrossReferences":[{"database":"PubMed","id":"7788527"},{"database":"DOI","id":"10.1093/dnares/2.1.37"}],"title":"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.","publicationDate":"1995","journal":"DNA Res.","firstPage":"37","lastPage":"43","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-8O6M6FJR7QHJH","citationType":"submission","authors":["Li W.B.","Gruber C.","Jessee J.","Polayes D."],"title":"Full-length cDNA libraries and normalization.","publicationDate":"APR-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-224 (ISOFORM 2)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"12456649","citationType":"journal article","authors":["Habu T.","Kim S.H.","Weinstein J.","Matsumoto T."],"citationCrossReferences":[{"database":"PubMed","id":"12456649"},{"database":"DOI","id":"10.1093/emboj/cdf659"}],"title":"Identification of a MAD2-binding protein, CMT2, and its role in mitosis.","publicationDate":"2002","journal":"EMBO J.","firstPage":"6419","lastPage":"6428","volume":"21"},"referencePositions":["POSSIBLE FUNCTION","INTERACTION WITH MAD2L1","SUBCELLULAR LOCATION","DEVELOPMENTAL STAGE"]},{"referenceNumber":8,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"18022368","citationType":"journal article","authors":["Yang M.","Li B.","Tomchick D.R.","Machius M.","Rizo J.","Yu H.","Luo X."],"citationCrossReferences":[{"database":"PubMed","id":"18022368"},{"database":"DOI","id":"10.1016/j.cell.2007.08.048"}],"title":"p31comet blocks Mad2 activation through structural mimicry.","publicationDate":"2007","journal":"Cell","firstPage":"744","lastPage":"755","volume":"131"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 36-274 IN COMPLEX WITH MAD2L1","FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH MAD2L1","MUTAGENESIS OF GLN-83 AND PHE-191"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D14811","properties":[{"key":"ProteinId","value":"BAA03552.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK297172","properties":[{"key":"ProteinId","value":"BAG59665.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR456893","properties":[{"key":"ProteinId","value":"CAG33174.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL136131","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353602","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC002904","properties":[{"key":"ProteinId","value":"AAH02904.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL537692","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS47431.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15013-3"},{"database":"CCDS","id":"CCDS4904.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15013-1"},{"database":"RefSeq","id":"NP_001003690.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001003690.2"}],"isoformId":"Q15013-3"},{"database":"RefSeq","id":"NP_055443.1","properties":[{"key":"NucleotideSequenceId","value":"NM_014628.3"}],"isoformId":"Q15013-1"},{"database":"PDB","id":"2QYF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=36-274"}]},{"database":"PDB","id":"6F0X","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.60 A"},{"key":"Chains","value":"P=1-274"}]},{"database":"PDBsum","id":"2QYF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6F0X","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-4166","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114955","properties":[{"key":"Interactions","value":"73"}]},{"database":"DIP","id":"DIP-34492N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q15013","properties":[{"key":"Number of interactors","value":"3324"}]},{"database":"IntAct","id":"Q15013","properties":[{"key":"Interactions","value":"57"}]},{"database":"MINT","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-MAD2L1BP","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000410818","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MAD2L1BP","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000410818","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19077","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"60365","properties":[{"key":"Description","value":"-"}],"isoformId":"Q15013-1"},{"database":"Pumba","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"30554","properties":[{"key":"antibodies","value":"318 antibodies from 35 providers"}]},{"database":"DNASU","id":"9587","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000372171.5","properties":[{"key":"ProteinId","value":"ENSP00000361244.4"},{"key":"GeneId","value":"ENSG00000124688.15"}],"isoformId":"Q15013-1"},{"database":"Ensembl","id":"ENST00000451025.6","properties":[{"key":"ProteinId","value":"ENSP00000410818.2"},{"key":"GeneId","value":"ENSG00000124688.15"}],"isoformId":"Q15013-3"},{"database":"Ensembl","id":"ENST00000924971.1","properties":[{"key":"ProteinId","value":"ENSP00000595030.1"},{"key":"GeneId","value":"ENSG00000124688.15"}],"isoformId":"Q15013-1"},{"database":"GeneID","id":"9587","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:9587","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000372171.5","properties":[{"key":"ProteinId","value":"ENSP00000361244.4"},{"key":"RefSeqNucleotideId","value":"NM_014628.3"},{"key":"RefSeqProteinId","value":"NP_055443.1"}]},{"database":"UCSC","id":"uc003ovu.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q15013-1"},{"database":"AGR","id":"HGNC:21059","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134911020","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9587","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"9587","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MAD2L1BP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:21059","properties":[{"key":"GeneName","value":"MAD2L1BP"}]},{"database":"HPA","id":"ENSG00000124688","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"618136","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000124688","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124688","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QTUF","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000003812","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_079654_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KCQQVLM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6334764at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q15013","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000124688","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"9587","properties":[{"key":"hits","value":"251 hits in 1168 CRISPR screens"}]},{"database":"ChiTaRS","id":"MAD2L1BP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"MAD2L1BP","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"9587","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q15013","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q15013","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q15013","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000124688","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of transverse colon and 187 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10942595"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10942595"}]},{"database":"GO","id":"GO:0005819","properties":[{"key":"GoTerm","value":"C:spindle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1902426","properties":[{"key":"GoTerm","value":"P:deactivation of mitotic spindle assembly checkpoint"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18022368"}]},{"database":"GO","id":"GO:0007096","properties":[{"key":"GoTerm","value":"P:regulation of exit from mitosis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12456649"}]},{"database":"DisProt","id":"DP03192","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.30.900.20:FF:000001","properties":[{"key":"EntryName","value":"MAD2L1 binding protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.900.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009511","properties":[{"key":"EntryName","value":"MAD1/Cdc20-bound-Mad2-bd"}]},{"database":"InterPro","id":"IPR053729","properties":[{"key":"EntryName","value":"MAD2L1BP_domain_sf"}]},{"database":"PANTHER","id":"PTHR15681","properties":[{"key":"EntryName","value":"MAD2L1-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15681:SF1","properties":[{"key":"EntryName","value":"MAD2L1-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06581","properties":[{"key":"EntryName","value":"p31comet"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAPEAEVLSSAAVPDLEWYEKSEETHASQIELLETSSTQEPLNASEAFCPRDCMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRKPSPQAEEMLKKKPRATTEVSSRKCQQALAELESVLSHLEDFFARTLVPRVLILLGGNALSPKEFYELDLSLLAPYSVDQSLSTAACLRRLFRAIFMADAFSELQAPPLMGTVVMAQGHRNCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPSIRTTAWEDYIWFQAPVTFKGFRE","length":274,"molWeight":31052,"crc64":"5C49FBE1F456105C","md5":"56F90A1D4441EF375C355E09CA57455D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Modified residue":1,"Alternative sequence":1,"Mutagenesis":2,"Sequence conflict":2,"Beta strand":9,"Helix":6,"Turn":2},"uniParcId":"UPI0000000C4A"}}