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Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11001926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17095724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24100041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24316715"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24407421"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24981863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29348140"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29506078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29507755"}],"value":"Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:24316715, PubMed:24407421, PubMed:24981863, PubMed:29348140, PubMed:29506078, PubMed:29507755). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29507755). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755). Interacts with WT1 (PubMed:11001926, PubMed:17095724). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 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