{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q14AI0","secondaryAccessions":["Q4FZL5"],"uniProtkbId":"DCC1_MOUSE","entryAudit":{"firstPublicDate":"2008-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-08-22","entryVersion":104,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Sister chromatid cohesion protein DCC1"}},"alternativeNames":[{"fullName":{"value":"Defective in sister chromatid cohesion protein 1 homolog"}}]},"genes":[{"geneName":{"value":"DSCC1"},"synonyms":[{"value":"DCC1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9BVC3"}],"value":"Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18. Interacts with DDX11"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the DCC1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Sister chromatid cohesion protein DCC1","featureId":"PRO_0000318065"}],"keywords":[{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Oocyte","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC099382","properties":[{"key":"ProteinId","value":"AAH99382.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC116833","properties":[{"key":"ProteinId","value":"AAI16834.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC116835","properties":[{"key":"ProteinId","value":"AAI16836.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS27473.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_898912.2","properties":[{"key":"NucleotideSequenceId","value":"NM_183089.3"}]},{"database":"AlphaFoldDB","id":"Q14AI0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q14AI0","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q14AI0","properties":[{"key":"Number of interactors","value":"2257"}]},{"database":"STRING","id":"10090.ENSMUSP00000023059","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q14AI0","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000023059","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"279161","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q14AI0","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"26822","properties":[{"key":"antibodies","value":"205 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENSMUST00000023059.13","properties":[{"key":"ProteinId","value":"ENSMUSP00000023059.7"},{"key":"GeneId","value":"ENSMUSG00000022422.14"}]},{"database":"GeneID","id":"72107","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:72107","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007vrw.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1919357","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79075","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1919357","properties":[{"key":"GeneName","value":"Dscc1"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000022422","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0798","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000017400","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q14AI0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DSESWPF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5199543at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q14AI0","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-174411","properties":[{"key":"PathwayName","value":"Polymerase switching on the C-strand of the telomere"}]},{"database":"BioGRID-ORCS","id":"72107","properties":[{"key":"hits","value":"18 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q14AI0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"Q14AI0","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000022422","properties":[{"key":"ExpressionPatterns","value":"Expressed in manus and 139 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q14AI0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000775","properties":[{"key":"GoTerm","value":"C:chromosome, centromeric region"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031390","properties":[{"key":"GoTerm","value":"C:Ctf18 RFC-like complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003689","properties":[{"key":"GoTerm","value":"F:DNA clamp loader activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0017116","properties":[{"key":"GoTerm","value":"F:single-stranded DNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034088","properties":[{"key":"GoTerm","value":"P:maintenance of mitotic sister chromatid cohesion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1900264","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034421","properties":[{"key":"GoTerm","value":"P:post-translational protein acetylation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006275","properties":[{"key":"GoTerm","value":"P:regulation of DNA replication"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR019128","properties":[{"key":"EntryName","value":"Dcc1"}]},{"database":"PANTHER","id":"PTHR13395:SF6","properties":[{"key":"EntryName","value":"SISTER CHROMATID COHESION PROTEIN DCC1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13395","properties":[{"key":"EntryName","value":"SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09724","properties":[{"key":"EntryName","value":"Dcc1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSPPSASRRTREEVDATLQVAKLNATELLPTVHCLSFSSGTGGAATGDFCLLELEPALCQQLEAGDSFVIRGDKDEQAVLCSKDKTYDLKIADTSNMLLFIPGCKTPDQLKEEETPSAIVHTEIFGFSNNYWELRRCRPKLKKLKRLLMENTYEGPDSQKEEDASRSKYTTEDLLNHIQASEEEIMAQLQVLNACEIGGYWRILEFDYEIKLLNHVTQLVDSESWSLDRVPLTVCLQELGPLEPEEMIEHCLKCYGKRYVDKDDVYFELDADKICRVTAEMLLQNAVKFNLAEFQEVWQQSVPEGMTTRLDQLKGLALVDRNSRPEIIFLLKVDDLPEGTQDRFNSLFSLREKWTEEDITPYIQDLCGEKQTIGALLTKYSRSSMQNGIKVYNSRRLIS","length":399,"molWeight":45522,"crc64":"7AF16514EF64D9E5","md5":"C3F7A82EBABA5B68AFE13472A8F8372F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI0000509A7D"}}