{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q14839","secondaryAccessions":["Q8IXZ5"],"uniProtkbId":"CHD4_HUMAN","entryAudit":{"firstPublicDate":"1999-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-11-02","entryVersion":251,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"ATP-dependent chromatin remodeler CHD4"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977666"}],"value":"3.6.4.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Chromo domain-containing protein 4"},"shortNames":[{"value":"CHD-4"}]},{"fullName":{"value":"Mi-2 autoantigen 218 kDa protein"}},{"fullName":{"value":"Mi2-beta"}}]},"genes":[{"geneName":{"value":"CHD4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6PDQ2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16428440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17626165"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25593309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32543371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9804427"}],"value":"ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977666"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32543371"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6RYR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6RYU"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6PDQ2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10204490"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10545197"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12198550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14530259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16428440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17626165"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19644445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21555454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23149945"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25593309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27616479"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29567837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30134174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33283408"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064715"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9804427"}],"value":"Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:10204490, PubMed:15454082, PubMed:16428440, PubMed:28977666, PubMed:33283408, PubMed:9804427). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:28977666, PubMed:33283408). Interacts with IKFZ1; the interaction is direct and when in part of the NuRD complex (By similarity). Part of a complex containing ATR and HDAC2 (PubMed:10545197). Interacts with HDAC2; the interaction is direct (PubMed:12198550, PubMed:25593309). Interacts with the cohesin complex component RAD21; the interaction is direct (PubMed:12198550). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (PubMed:12198550). Interacts with ZGPAT; the interaction is direct (PubMed:19644445). Interacts with ZMYND8; the interaction is direct, appears to occur with monomeric ZMYND8, and is increased following DNA damage (PubMed:25593309, PubMed:30134174, PubMed:36064715). Interacts with BCL6 (PubMed:15454082). Interacts with BRD4 (PubMed:21555454). Interacts with CBX1 (PubMed:28977666). Interacts with CBX3 (PubMed:28977666). Interacts with CBX5 (PubMed:28977666). Interacts with GATAD2A (PubMed:33283408). Interacts with HDAC1 (PubMed:25593309, PubMed:27616479, PubMed:28977666, PubMed:36064715). Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (By similarity). Interacts with MTA1 (PubMed:28977666). Interacts with PCNT (PubMed:17626165). Interacts with RBBP7 (PubMed:28977666). Interacts with SETX (PubMed:23149945). Interacts with TRIM27 (PubMed:14530259). Interacts with histone H3 (PubMed:32543371). Interacts with histone H4 (PubMed:32543371). Does not interact with PWWP2A (By similarity). Does not interact with PWWP2B (By similarity). Interacts (via KIKL motif) with BRD3 (via NET domain) (PubMed:29567837)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q14839","intActId":"EBI-372916"},"interactantTwo":{"uniProtKBAccession":"Q13547","geneName":"HDAC1","intActId":"EBI-301834"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q14839","intActId":"EBI-372916"},"interactantTwo":{"uniProtKBAccession":"P01106","geneName":"MYC","intActId":"EBI-447544"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q14839","intActId":"EBI-372916"},"interactantTwo":{"uniProtKBAccession":"Q17R98","geneName":"ZNF827","intActId":"EBI-5564776"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q14839","intActId":"EBI-372916"},"interactantTwo":{"uniProtKBAccession":"P70326","geneName":"Tbx5","intActId":"EBI-8411807"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6PDQ2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27732854"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977666"}],"value":"Associates with centrosomes in interphase (By similarity). 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