{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q13936","secondaryAccessions":["B2RUT3","E9PDJ0","Q13917","Q13918","Q13919","Q13920","Q13921","Q13922","Q13923","Q13924","Q13925","Q13926","Q13927","Q13928","Q13929","Q13930","Q13932","Q13933","Q14743","Q14744","Q15877","Q4VMI7","Q4VMI8","Q4VMI9","Q6PKM7","Q8N6C0","Q99025","Q99241","Q99875"],"uniProtkbId":"CAC1C_HUMAN","entryAudit":{"firstPublicDate":"1999-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-10-05","entryVersion":255,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Voltage-dependent L-type calcium channel subunit alpha-1C"}},"alternativeNames":[{"fullName":{"value":"Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle"}},{"fullName":{"value":"Voltage-gated calcium channel subunit alpha Cav1.2"}}]},"genes":[{"geneName":{"value":"CACNA1C"},"synonyms":[{"value":"CACH2"},{"value":"CACN2"},{"value":"CACNL1A1"},{"value":"CCHL1A1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P15381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12181424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15863612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16299511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20953164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23677916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24728418"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25260352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25633834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26253506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27218670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28119464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29078335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29742403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30023270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30172029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31430211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34163037"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8099908"},{"evidenceCode":"ECO:0000305"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12176756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7737988"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 12"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 13"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 14"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 15"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9087614"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 16"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9087614"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 17"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8392192"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 18"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7737988"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 19"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7737988"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 20"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9607315"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 21"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9607315"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 22"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9607315"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 23"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 24"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 25"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9013606"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 26"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9013606"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 27"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11741969"}],"value":"Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents"}],"commentType":"FUNCTION","molecule":"Isoform 34"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29779930"}],"value":"(Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12181424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15863612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16299511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20953164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23677916"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24728418"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25260352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25633834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26253506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27218670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28119464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29078335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30023270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30172029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31430211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34163037"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8099908"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 12","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12176756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7737988"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 13","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 14","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 15","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 16","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9087614"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 17","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9087614"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 18","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8392192"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 19","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7737988"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 20","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7737988"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 21","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9607315"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 22","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9607315"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 23","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9607315"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 24","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 25","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17071743"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 26","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9013606"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 27","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9013606"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 34","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11741969"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P15381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12176756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15140941"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15980432"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29078335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29742403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7737988"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8099908"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8392192"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9607315"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16299511"}],"value":"Inhibited by dihydropyridines (DHP), such as isradipine (PubMed:7737988, PubMed:8099908, PubMed:8392192, PubMed:9607315). Inhibited by nifedipine (By similarity). Selectively inhibited by the snake venom calciseptine (PubMed:37972591). Inhibited by pinaverium bromide (PIN) (PubMed:37972591). Channel activity is regulated by Ca(2+) and calmodulin (Probable) (PubMed:29742403). Binding of STAC1, STAC2 or STAC3 to a region that overlaps with the calmodulin binding site inhibits channel inactivation by Ca(2+) and calmodulin (PubMed:29078335). Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function (PubMed:15140941, PubMed:15980432). Shear stress and pressure increases calcium channel activity (PubMed:12176756)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P15381"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01815"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11741969"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12176756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12181424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15140941"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15141227"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15863612"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15980432"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16299511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16338416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17224476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19279214"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20953164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22518098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24728418"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29078335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29742403"},{"evidenceCode":"ECO:0000305"}],"value":"Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and ancillary beta, gamma and delta subunits (PubMed:12176756, PubMed:12181424, PubMed:15141227, PubMed:16299511, PubMed:20953164, PubMed:29078335, PubMed:29742403). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains only one of each type of subunit (Probable). CACNA1C channel activity is modulated by ancillary subunits, such as CACNB1, CACNB2, CACNB3, CACNA2D1 and CACNA2D4 (PubMed:11741969, PubMed:12181424, PubMed:17224476, PubMed:29742403). Interacts with the gamma subunits CACNG4, CACNG6, CACNG7 and CACNG8 (By similarity). Interacts with CACNB1 (By similarity). Interacts with CACNB2 (PubMed:11741969, PubMed:12176756, PubMed:15141227, PubMed:15863612, PubMed:17224476, PubMed:20953164, PubMed:24728418, PubMed:29742403). Identified in a complex with CACNA2D4 and CACNB3 (PubMed:12181424). Interacts with CACNB3 (PubMed:12181424, PubMed:29742403). Interacts with CACNA2D1 (PubMed:15863612, PubMed:20953164, PubMed:24728418, PubMed:29742403). Interacts with CACNA2D4 (PubMed:12181424). Interacts with CALM1 (PubMed:16299511, PubMed:16338416, PubMed:19279214, PubMed:20953164, PubMed:22518098, PubMed:29742403). Interacts (via the N-terminus and the C-terminal C and IQ motifs) with CABP1; this inhibits Ca(2+)-dependent channel inactivation (PubMed:15140941, PubMed:15980432). The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding (PubMed:15140941). The binding to the cytoplasmic N-terminal domain is calcium independent but is essential for the channel modulation. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner (By similarity). Interacts with CIB1; the interaction increases upon cardiomyocytes hypertrophy (By similarity). Interacts with STAC2 and STAC3; this inhibits channel inactivation (PubMed:29078335). Interacts (via N-terminus) with LRRC7; in neurons, the interaction enhances channel trafficking to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29779930"}],"value":"(Microbial infection) Interacts with influenzavirus H1 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Overall expression is reduced in atherosclerotic vascular smooth muscle"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P15381"}],"value":"Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28119464"}],"value":"Phosphorylation by PKA at Ser-1981 activates the channel. 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