{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q13492","secondaryAccessions":["B4DTM3","E9PN05","F8VPG7","O60700","Q4LE54","Q6GMQ6","Q86XZ9"],"uniProtkbId":"PICAL_HUMAN","entryAudit":{"firstPublicDate":"2002-11-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-17","entryVersion":218,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Phosphatidylinositol-binding clathrin assembly protein"}},"alternativeNames":[{"fullName":{"value":"Clathrin assembly lymphoid myeloid leukemia protein"}}]},"genes":[{"geneName":{"value":"PICALM"},"synonyms":[{"value":"CALM"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10436022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16262731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21808019"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22118466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23741335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24067654"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25241929"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25898166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27574975"}],"value":"Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16262731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21808019"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22118466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23741335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24067654"}],"value":"Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with PIMREG; this interaction may change the subcellular location into the nucleus (PubMed:16491119). Interacts with AP2A1 (via its alpha-appendage domain) (PubMed:16262731). Interacts (via N-terminus) with VAMP2; VAMP3; VAMP7 and VAMP8 (Via N-terminus) (PubMed:21808019, PubMed:22118466, PubMed:23741335). Interacts with LC3/MAP1LC3A (PubMed:24067654)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q13492","intActId":"EBI-2803688"},"interactantTwo":{"uniProtKBAccession":"P42566","geneName":"EPS15","intActId":"EBI-396684"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13492","intActId":"EBI-2803688"},"interactantTwo":{"uniProtKBAccession":"Q14192","geneName":"FHL2","intActId":"EBI-701903"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13492-3","intActId":"EBI-11031437"},"interactantTwo":{"uniProtKBAccession":"P54253","geneName":"ATXN1","intActId":"EBI-930964"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13492-3","intActId":"EBI-11031437"},"interactantTwo":{"uniProtKBAccession":"P0C7T5","geneName":"ATXN1L","intActId":"EBI-8624731"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13492-3","intActId":"EBI-11031437"},"interactantTwo":{"uniProtKBAccession":"Q96K80","geneName":"ZC3H10","intActId":"EBI-742550"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10436022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"}],"value":"Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16262731"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10436022"}],"value":"Membrane, clathrin-coated pit","id":"SL-0069"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10436022"}],"value":"Golgi apparatus","id":"SL-0132"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10436022"}],"value":"Cytoplasmic vesicle, clathrin-coated vesicle","id":"SL-0070"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Type I"}],"isoformIds":["Q13492-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Type II"}],"isoformIds":["Q13492-2"],"sequenceIds":["VSP_004067"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q13492-3"],"sequenceIds":["VSP_009607","VSP_009608"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q13492-4"],"sequenceIds":["VSP_044567","VSP_009607"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q13492-5"],"sequenceIds":["VSP_044568"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643484"}],"value":"Expressed in all tissues examined"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643484"}],"value":"A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PICALM/SNAP91 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAE06099.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/64/CALM","ftp":false}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"Phosphatidylinositol-binding clathrin assembly protein","featureId":"PRO_0000187062"},{"type":"Domain","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"ENTH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00243"}]},{"type":"Region","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Interaction with PIMREG","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"}]},{"type":"Region","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":649,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form CALM/MLLT10 fusion protein"},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_044567","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_009607","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_044568","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_009608","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MNGMHFPQY"]}},{"type":"Alternative sequence","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9737689"}],"featureId":"VSP_004067","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"in dbSNP:rs12800974","featureCrossReferences":[{"database":"dbSNP","id":"rs12800974"}],"featureId":"VAR_028191","alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"in dbSNP:rs12222608","featureCrossReferences":[{"database":"dbSNP","id":"rs12222608"}],"featureId":"VAR_028192","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":578,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"in dbSNP:rs1043858","featureCrossReferences":[{"database":"dbSNP","id":"rs1043858"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9737689"}],"featureId":"VAR_028193","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":579,"modifier":"EXACT"}},"description":"in dbSNP:rs1043859","featureCrossReferences":[{"database":"dbSNP","id":"rs1043859"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9737689"}],"featureId":"VAR_028194","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"in dbSNP:rs556337","featureCrossReferences":[{"database":"dbSNP","id":"rs556337"}],"featureId":"VAR_028195","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in Ref. 2; BAG62035","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in Ref. 1; AAB07762","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in Ref. 2; BAG62035","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0168","category":"Cellular component","name":"Coated pit"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0254","category":"Biological process","name":"Endocytosis"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0656","category":"Disease","name":"Proto-oncogene"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"8643484","citationType":"journal article","authors":["Dreyling M.H.","Martinez-Climent J.A.","Zheng M.","Mao J.","Rowley J.D.","Bohlander S.K."],"citationCrossReferences":[{"database":"PubMed","id":"8643484"},{"database":"DOI","id":"10.1073/pnas.93.10.4804"}],"title":"The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.","publicationDate":"1996","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4804","lastPage":"4809","volume":"93"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","CHROMOSOMAL TRANSLOCATION","TISSUE SPECIFICITY","VARIANTS CYS-578 AND GLU-579"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-1DVUKGU9SI55Q","citationType":"submission","authors":["Nakajima D.","Saito K.","Yamakawa H.","Kikuno R.F.","Nakayama M.","Ohara R.","Okazaki N.","Koga H.","Nagase T.","Ohara O."],"title":"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method.","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.-W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.-S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)"],"referenceComments":[{"value":"PNS","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"9737689","citationType":"journal article","authors":["Silliman C.C.","McGavran L.","Wei Q.","Miller L.A.","Li S.","Hunger S.P."],"citationCrossReferences":[{"database":"PubMed","id":"9737689"},{"database":"DOI","id":"10.1038/sj.leu.2401109"}],"title":"Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.","publicationDate":"1998","journal":"Leukemia","firstPage":"1404","lastPage":"1410","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 575-652 (ISOFORMS 1 AND 2)","VARIANTS CYS-578 AND GLU-579"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"10436022","citationType":"journal article","authors":["Tebar F.","Bohlander S.K.","Sorkin A."],"citationCrossReferences":[{"database":"PubMed","id":"10436022"},{"database":"DOI","id":"10.1091/mbc.10.8.2687"}],"title":"Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.","publicationDate":"1999","journal":"Mol. Biol. Cell","firstPage":"2687","lastPage":"2702","volume":"10"},"referencePositions":["FUNCTION","INTERACTION WITH CLATHRIN","SUBCELLULAR LOCATION"]},{"referenceNumber":9,"citation":{"id":"16262731","citationType":"journal article","authors":["Meyerholz A.","Hinrichsen L.","Groos S.","Esk P.C.","Brandes G.","Ungewickell E.J."],"citationCrossReferences":[{"database":"PubMed","id":"16262731"},{"database":"DOI","id":"10.1111/j.1600-0854.2005.00355.x"}],"title":"Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation.","publicationDate":"2005","journal":"Traffic","firstPage":"1225","lastPage":"1234","volume":"6"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH AP2A1 AND CLATHRIN"]},{"referenceNumber":10,"citation":{"id":"16491119","citationType":"journal article","authors":["Archangelo L.F.","Glaesner J.","Krause A.","Bohlander S.K."],"citationCrossReferences":[{"database":"PubMed","id":"16491119"},{"database":"DOI","id":"10.1038/sj.onc.1209438"}],"title":"The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10.","publicationDate":"2006","journal":"Oncogene","firstPage":"4099","lastPage":"4109","volume":"25"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH PIMREG"]},{"referenceNumber":11,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"22118466","citationType":"journal article","authors":["Miller S.E.","Sahlender D.A.","Graham S.C.","Honing S.","Robinson M.S.","Peden A.A.","Owen D.J."],"citationCrossReferences":[{"database":"PubMed","id":"22118466"},{"database":"DOI","id":"10.1016/j.cell.2011.10.038"}],"title":"The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.","publicationDate":"2011","journal":"Cell","firstPage":"1118","lastPage":"1131","volume":"147"},"referencePositions":["FUNCTION","INTERACTION WITH VAMP2; VAMP3 AND VAMP8"]},{"referenceNumber":16,"citation":{"id":"21808019","citationType":"journal article","authors":["Koo S.J.","Markovic S.","Puchkov D.","Mahrenholz C.C.","Beceren-Braun F.","Maritzen T.","Dernedde J.","Volkmer R.","Oschkinat H.","Haucke V."],"citationCrossReferences":[{"database":"PubMed","id":"21808019"},{"database":"DOI","id":"10.1073/pnas.1107067108"}],"title":"SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.","publicationDate":"2011","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13540","lastPage":"13545","volume":"108"},"referencePositions":["FUNCTION","INTERACTION WITH VAMP2"]},{"referenceNumber":17,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"23741335","citationType":"journal article","authors":["Sahlender D.A.","Kozik P.","Miller S.E.","Peden A.A.","Robinson M.S."],"citationCrossReferences":[{"database":"PubMed","id":"23741335"},{"database":"DOI","id":"10.1371/journal.pone.0064514"}],"title":"Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E64514","lastPage":"E64514","volume":"8"},"referencePositions":["FUNCTION","INTERACTION WITH VAMP7"]},{"referenceNumber":20,"citation":{"id":"24067654","citationType":"journal article","authors":["Tian Y.","Chang J.C.","Fan E.Y.","Flajolet M.","Greengard P."],"citationCrossReferences":[{"database":"PubMed","id":"24067654"},{"database":"DOI","id":"10.1073/pnas.1315110110"}],"title":"Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.","publicationDate":"2013","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"17071","lastPage":"17076","volume":"110"},"referencePositions":["FUNCTION","INTERACTION WITH LC3/MAP1LC3A"]},{"referenceNumber":21,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-20; SER-303 AND SER-315","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-238","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":24,"citation":{"id":"25241929","citationType":"journal article","authors":["Moreau K.","Fleming A.","Imarisio S.","Lopez Ramirez A.","Mercer J.L.","Jimenez-Sanchez M.","Bento C.F.","Puri C.","Zavodszky E.","Siddiqi F.","Lavau C.P.","Betton M.","O'Kane C.J.","Wechsler D.S.","Rubinsztein D.C."],"citationCrossReferences":[{"database":"PubMed","id":"25241929"},{"database":"DOI","id":"10.1038/ncomms5998"}],"title":"PICALM modulates autophagy activity and tau accumulation.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4998","lastPage":"4998","volume":"5"},"referencePositions":["FUNCTION"]},{"referenceNumber":25,"citation":{"id":"25898166","citationType":"journal article","authors":["Miller S.E.","Mathiasen S.","Bright N.A.","Pierre F.","Kelly B.T.","Kladt N.","Schauss A.","Merrifield C.J.","Stamou D.","Hoening S.","Owen D.J."],"citationCrossReferences":[{"database":"PubMed","id":"25898166"},{"database":"DOI","id":"10.1016/j.devcel.2015.03.002"}],"title":"CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.","publicationDate":"2015","journal":"Dev. Cell","firstPage":"163","lastPage":"175","volume":"33"},"referencePositions":["FUNCTION"]},{"referenceNumber":26,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"27574975","citationType":"journal article","authors":["Moshkanbaryans L.","Xue J.","Wark J.R.","Robinson P.J.","Graham M.E."],"citationCrossReferences":[{"database":"PubMed","id":"27574975"},{"database":"DOI","id":"10.1371/journal.pone.0162050"}],"title":"A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly.","publicationDate":"2016","journal":"PLoS ONE","firstPage":"E0162050","lastPage":"E0162050","volume":"11"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U45976","properties":[{"key":"ProteinId","value":"AAB07762.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK300275","properties":[{"key":"ProteinId","value":"BAG62035.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB210017","properties":[{"key":"ProteinId","value":"BAE06099.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AP000767","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471076","properties":[{"key":"ProteinId","value":"EAW75120.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC048259","properties":[{"key":"ProteinId","value":"AAH48259.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC064357","properties":[{"key":"ProteinId","value":"AAH64357.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC073961","properties":[{"key":"ProteinId","value":"AAH73961.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF060939","properties":[{"key":"ProteinId","value":"AAC16711.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF060940","properties":[{"key":"ProteinId","value":"AAC16712.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS31653.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-3"},{"database":"CCDS","id":"CCDS55783.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-4"},{"database":"CCDS","id":"CCDS55784.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-5"},{"database":"CCDS","id":"CCDS8272.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-1"},{"database":"CCDS","id":"CCDS91570.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-2"},{"database":"RefSeq","id":"NP_001008660.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001008660.3"}],"isoformId":"Q13492-3"},{"database":"RefSeq","id":"NP_001193875.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206946.2"}],"isoformId":"Q13492-5"},{"database":"RefSeq","id":"NP_001193876.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001206947.2"}],"isoformId":"Q13492-4"},{"database":"RefSeq","id":"NP_001397963.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001411034.1"}],"isoformId":"Q13492-2"},{"database":"RefSeq","id":"NP_009097.2","properties":[{"key":"NucleotideSequenceId","value":"NM_007166.4"}],"isoformId":"Q13492-1"},{"database":"AlphaFoldDB","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113902","properties":[{"key":"Interactions","value":"299"}]},{"database":"CORUM","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q13492","properties":[{"key":"Number of interactors","value":"3108"}]},{"database":"IntAct","id":"Q13492","properties":[{"key":"Interactions","value":"156"}]},{"database":"MINT","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PICALM","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000377015","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6067239","properties":[{"key":"Description","value":"-"}]},{"database":"MoonDB","id":"Q13492","properties":[{"key":"Type","value":"Curated"}]},{"database":"MoonProt","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q13492","properties":[{"key":"glycosylation","value":"16 sites, 2 glycans"}]},{"database":"GlyGen","id":"Q13492","properties":[{"key":"glycosylation","value":"35 sites, 2 O-linked glycans (35 sites)"}]},{"database":"iPTMnet","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PICALM","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"116242714","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000377015","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"22268","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"28286","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"59489","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-1"},{"database":"ProteomicsDB","id":"59490","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-2"},{"database":"ProteomicsDB","id":"59491","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13492-3"},{"database":"Pumba","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"17636","properties":[{"key":"antibodies","value":"212 antibodies from 36 providers"}]},{"database":"DNASU","id":"8301","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000356360.9","properties":[{"key":"ProteinId","value":"ENSP00000348718.5"},{"key":"GeneId","value":"ENSG00000073921.19"}],"isoformId":"Q13492-2"},{"database":"Ensembl","id":"ENST00000393346.8","properties":[{"key":"ProteinId","value":"ENSP00000377015.3"},{"key":"GeneId","value":"ENSG00000073921.19"}],"isoformId":"Q13492-1"},{"database":"Ensembl","id":"ENST00000526033.5","properties":[{"key":"ProteinId","value":"ENSP00000433846.1"},{"key":"GeneId","value":"ENSG00000073921.19"}],"isoformId":"Q13492-5"},{"database":"Ensembl","id":"ENST00000528398.5","properties":[{"key":"ProteinId","value":"ENSP00000434884.1"},{"key":"GeneId","value":"ENSG00000073921.19"}],"isoformId":"Q13492-4"},{"database":"Ensembl","id":"ENST00000532317.5","properties":[{"key":"ProteinId","value":"ENSP00000436958.1"},{"key":"GeneId","value":"ENSG00000073921.19"}],"isoformId":"Q13492-3"},{"database":"GeneID","id":"8301","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:8301","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000393346.8","properties":[{"key":"ProteinId","value":"ENSP00000377015.3"},{"key":"RefSeqNucleotideId","value":"NM_007166.4"},{"key":"RefSeqProteinId","value":"NP_009097.2"}]},{"database":"UCSC","id":"uc001pbl.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q13492-1"},{"database":"AGR","id":"HGNC:15514","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA33287","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8301","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"8301","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PICALM","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15514","properties":[{"key":"GeneName","value":"PICALM"}]},{"database":"HPA","id":"ENSG00000073921","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"PICALM","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"603025","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000073921","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"99861","properties":[{"key":"Disease","value":"Precursor T-cell acute lymphoblastic leukemia"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000073921","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0251","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183068","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_014080_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"XVNSNEL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"44015at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q13492","properties":[{"key":"Number of GO annotations","value":"10 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-432722","properties":[{"key":"PathwayName","value":"Golgi Associated Vesicle Biogenesis"}]},{"database":"Reactome","id":"R-HSA-8856825","properties":[{"key":"PathwayName","value":"Cargo recognition for clathrin-mediated endocytosis"}]},{"database":"Reactome","id":"R-HSA-8856828","properties":[{"key":"PathwayName","value":"Clathrin-mediated endocytosis"}]},{"database":"Reactome","id":"R-HSA-9696264","properties":[{"key":"PathwayName","value":"RND3 GTPase cycle"}]},{"database":"SignaLink","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000073921","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"8301","properties":[{"key":"hits","value":"50 hits in 1166 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"PICALM","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"PICALM","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"8301","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q13492","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q13492","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q13492","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000073921","properties":[{"key":"ExpressionPatterns","value":"Expressed in calcaneal tendon and 203 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q13492","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0030132","properties":[{"key":"GoTerm","value":"C:clathrin coat of coated pit"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10436022"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16262731"}]},{"database":"GO","id":"GO:0045334","properties":[{"key":"GoTerm","value":"C:clathrin-coated endocytic vesicle"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25898166"}]},{"database":"GO","id":"GO:0005905","properties":[{"key":"GoTerm","value":"C:clathrin-coated pit"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10436022"}]},{"database":"GO","id":"GO:0030136","properties":[{"key":"GoTerm","value":"C:clathrin-coated vesicle"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25898166"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0070381","properties":[{"key":"GoTerm","value":"C:endosome to plasma membrane transport vesicle"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0098894","properties":[{"key":"GoTerm","value":"C:extrinsic component of presynaptic endocytic zone membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10436022"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0097418","properties":[{"key":"GoTerm","value":"C:neurofibrillary tangle"},{"key":"GoEvidenceType","value":"IMP:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23589030"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IDA:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23589030"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16491119"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16262731"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0042734","properties":[{"key":"GoTerm","value":"C:presynaptic membrane"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0008021","properties":[{"key":"GoTerm","value":"C:synaptic vesicle"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031982","properties":[{"key":"GoTerm","value":"C:vesicle"},{"key":"GoEvidenceType","value":"ISS:Alzheimers_University_of_Toronto"}]},{"database":"GO","id":"GO:0005545","properties":[{"key":"GoTerm","value":"F:1-phosphatidylinositol binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001540","properties":[{"key":"GoTerm","value":"F:amyloid-beta binding"},{"key":"GoEvidenceType","value":"IC:ARUK-UCL"}]},{"database":"GO","id":"GO:0045296","properties":[{"key":"GoTerm","value":"F:cadherin binding"},{"key":"GoEvidenceType","value":"HDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"25468996"}]},{"database":"GO","id":"GO:0030276","properties":[{"key":"GoTerm","value":"F:clathrin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10436022"}]},{"database":"GO","id":"GO:0032050","properties":[{"key":"GoTerm","value":"F:clathrin heavy chain binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10436022"}]},{"database":"GO","id":"GO:0050750","properties":[{"key":"GoTerm","value":"F:low-density lipoprotein particle receptor binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0005546","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-4,5-bisphosphate binding"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"25898166"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0000149","properties":[{"key":"GoTerm","value":"F:SNARE binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22118466"}]},{"database":"GO","id":"GO:0048156","properties":[{"key":"GoTerm","value":"F:tau protein binding"},{"key":"GoEvidenceType","value":"IPI:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23589030"}]},{"database":"GO","id":"GO:0150093","properties":[{"key":"GoTerm","value":"P:amyloid-beta clearance by transcytosis"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0048268","properties":[{"key":"GoTerm","value":"P:clathrin coat assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16262731"}]},{"database":"GO","id":"GO:0072583","properties":[{"key":"GoTerm","value":"P:clathrin-dependent endocytosis"},{"key":"GoEvidenceType","value":"IMP:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22952941"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24577224"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0006897","properties":[{"key":"GoTerm","value":"P:endocytosis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22118466"}]},{"database":"GO","id":"GO:0016197","properties":[{"key":"GoTerm","value":"P:endosomal transport"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16262731"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22952941"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0097753","properties":[{"key":"GoTerm","value":"P:membrane bending"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25898166"}]},{"database":"GO","id":"GO:0060586","properties":[{"key":"GoTerm","value":"P:multicellular organismal-level iron ion homeostasis"},{"key":"GoEvidenceType","value":"IMP:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22952941"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22952941"}]},{"database":"GO","id":"GO:2000009","properties":[{"key":"GoTerm","value":"P:negative regulation of protein localization to cell surface"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21221849"}]},{"database":"GO","id":"GO:1903077","properties":[{"key":"GoTerm","value":"P:negative regulation of protein localization to plasma membrane"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21221849"}]},{"database":"GO","id":"GO:0048261","properties":[{"key":"GoTerm","value":"P:negative regulation of receptor-mediated endocytosis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10436022"}]},{"database":"GO","id":"GO:1902993","properties":[{"key":"GoTerm","value":"P:positive regulation of amyloid precursor protein catabolic process"},{"key":"GoEvidenceType","value":"ISS:Alzheimers_University_of_Toronto"}]},{"database":"GO","id":"GO:1902004","properties":[{"key":"GoTerm","value":"P:positive regulation of amyloid-beta formation"},{"key":"GoEvidenceType","value":"IMP:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24577224"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11425879"}]},{"database":"GO","id":"GO:0046579","properties":[{"key":"GoTerm","value":"P:positive regulation of Ras protein signal transduction"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26005850"}]},{"database":"GO","id":"GO:0065003","properties":[{"key":"GoTerm","value":"P:protein-containing complex assembly"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8643484"}]},{"database":"GO","id":"GO:0031623","properties":[{"key":"GoTerm","value":"P:receptor internalization"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14985334"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25898166"}]},{"database":"GO","id":"GO:0006898","properties":[{"key":"GoTerm","value":"P:receptor-mediated endocytosis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10436022"}]},{"database":"GO","id":"GO:1902991","properties":[{"key":"GoTerm","value":"P:regulation of amyloid precursor protein catabolic process"},{"key":"GoEvidenceType","value":"IMP:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24577224"}]},{"database":"GO","id":"GO:0030100","properties":[{"key":"GoTerm","value":"P:regulation of endocytosis"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18182011"}]},{"database":"GO","id":"GO:0032880","properties":[{"key":"GoTerm","value":"P:regulation of protein localization"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10436022"}]},{"database":"GO","id":"GO:0097494","properties":[{"key":"GoTerm","value":"P:regulation of vesicle size"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25898166"}]},{"database":"GO","id":"GO:0016188","properties":[{"key":"GoTerm","value":"P:synaptic vesicle maturation"},{"key":"GoEvidenceType","value":"ISS:Alzheimers_University_of_Toronto"}]},{"database":"GO","id":"GO:0006900","properties":[{"key":"GoTerm","value":"P:vesicle budding from membrane"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25898166"}]},{"database":"GO","id":"GO:0035459","properties":[{"key":"GoTerm","value":"P:vesicle cargo loading"},{"key":"GoEvidenceType","value":"IMP:Alzheimers_University_of_Toronto"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24577224"}]},{"database":"GO","id":"GO:0016192","properties":[{"key":"GoTerm","value":"P:vesicle-mediated transport"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8643484"}]},{"database":"CDD","id":"cd16985","properties":[{"key":"EntryName","value":"ANTH_N_AP180"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.150:FF:000001","properties":[{"key":"EntryName","value":"phosphatidylinositol-binding clathrin assembly protein-like isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.90:FF:000001","properties":[{"key":"EntryName","value":"phosphatidylinositol-binding clathrin assembly protein-like isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.90","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.150","properties":[{"key":"EntryName","value":"ANTH domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011417","properties":[{"key":"EntryName","value":"ANTH_dom"}]},{"database":"InterPro","id":"IPR014712","properties":[{"key":"EntryName","value":"ANTH_dom_sf"}]},{"database":"InterPro","id":"IPR045192","properties":[{"key":"EntryName","value":"AP180-like"}]},{"database":"InterPro","id":"IPR013809","properties":[{"key":"EntryName","value":"ENTH"}]},{"database":"InterPro","id":"IPR008942","properties":[{"key":"EntryName","value":"ENTH_VHS"}]},{"database":"PANTHER","id":"PTHR22951","properties":[{"key":"EntryName","value":"CLATHRIN ASSEMBLY PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22951:SF16","properties":[{"key":"EntryName","value":"PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07651","properties":[{"key":"EntryName","value":"ANTH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00273","properties":[{"key":"EntryName","value":"ENTH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48464","properties":[{"key":"EntryName","value":"ENTH/VHS domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF89009","properties":[{"key":"EntryName","value":"GAT-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50942","properties":[{"key":"EntryName","value":"ENTH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM","length":652,"molWeight":70755,"crc64":"AC3227E9D32AFEDA","md5":"C7B5D606AC2E0233AB47B0F5B9EAD1FF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":5,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":5,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":1,"Region":2,"Site":1,"Modified residue":5,"Cross-link":1,"Alternative sequence":5,"Natural variant":5,"Sequence conflict":3},"uniParcId":"UPI00001AE879"}}