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The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11991638"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12234937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12738865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15146077"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25737013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26030138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27720643"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27905398"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28541300"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32494006"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33509932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34822310"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36797247"}],"value":"Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:11991638, PubMed:12234937, PubMed:15146077, PubMed:32494006, PubMed:34822310, PubMed:36797247). Part of the SF3B subcomplex of the 17S U2 SnRNP complex (PubMed:12234937, PubMed:12738865, PubMed:27720643, PubMed:28541300). SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937). Within the SF3B complex, interacts directly with SF3B4 (PubMed:25737013). Found in a complex with PRMT9, SF3B2 and SF3B4 (PubMed:25737013). Interacts (Arg-508-methylated form) with SMN1 (via Tudor domain) (PubMed:25737013). Interacts with RBM7 (PubMed:27905398). Interacts with ERCC6 (PubMed:26030138). Component of the minor spliceosome (PubMed:15146077, PubMed:33509932). Within this complex, interacts with SCNM1 and CRIPT (PubMed:33509932)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16923959"}],"value":"(Microbial infection) Interacts with HIV-1 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