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Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (PubMed:15502821). Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (By similarity). Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P23198"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10330177"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11242053"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12004135"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15502821"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20562864"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20850016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21346195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23251473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23542155"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28167679"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28977666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32051553"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9169472"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9636146"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9864353"}],"value":"Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9' (PubMed:11242053). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with INCENP, TRIM28/TIF1B, KMT5B, KMT5C and SP100 (PubMed:10330177, PubMed:12004135, PubMed:9636146). Interacts with TIF1A (By similarity). Interacts with MIS12 and DSN1 (PubMed:15502821). Can interact directly with CBX5 via the chromoshadow domain (PubMed:9169472). Interacts with POGZ (PubMed:20562864, PubMed:20850016). Interacts with CHAMP1 (PubMed:20850016). The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Interacts with INCENP (PubMed:21346195, PubMed:9864353). Interacts with NIPBL (via PxVxL motif) (PubMed:28167679). Interacts with LRIF1 (via PxVxL motif) (PubMed:23542155). Interacts with TTLL12 (PubMed:23251473). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (PubMed:32051553). Interacts with CHD3 (PubMed:28977666). Interacts with CHD4 (PubMed:28977666)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q9H2P0","geneName":"ADNP","intActId":"EBI-1764854"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q6IQ32","geneName":"ADNP2","intActId":"EBI-2838654"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q13185","geneName":"CBX3","intActId":"EBI-78176"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q99988","geneName":"GDF15","intActId":"EBI-2116863"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"P68431","geneName":"H3C12","intActId":"EBI-79722"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q86Y97","geneName":"KMT5C","intActId":"EBI-7960569"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"P28838","geneName":"LAP3","intActId":"EBI-2339312"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q14739","geneName":"LBR","intActId":"EBI-1055147"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q5T3J3","geneName":"LRIF1","intActId":"EBI-473196"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q8IWI9","geneName":"MGA","intActId":"EBI-2815196"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"P52815","geneName":"MRPL12","intActId":"EBI-358272"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q9BWN1","geneName":"PRR14","intActId":"EBI-748167"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q9Y4B4","geneName":"RAD54L2","intActId":"EBI-948156"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"P23497-2","geneName":"SP100","intActId":"EBI-6589365"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"O75716","geneName":"STK16","intActId":"EBI-749295"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"O43463","geneName":"SUV39H1","intActId":"EBI-349968"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q13263","geneName":"TRIM28","intActId":"EBI-78139"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q8ND82","geneName":"ZNF280C","intActId":"EBI-8831272"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q6N043-2","geneName":"ZNF280D","intActId":"EBI-12027202"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13185","intActId":"EBI-78176"},"interactantTwo":{"uniProtKBAccession":"Q5ZUS4","geneName":"legAS4","intActId":"EBI-8871796"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Associates with euchromatin and is largely excluded from constitutive heterochromatin. 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