{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q12488","secondaryAccessions":["D6VRZ9"],"uniProtkbId":"PSF1_YEAST","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":191,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"DNA replication complex GINS protein PSF1"}},"alternativeNames":[{"fullName":{"value":"Partner of Sld five 1"}}]},"genes":[{"geneName":{"value":"PSF1"},"orderedLocusNames":[{"value":"YDR013W"}],"orfNames":[{"value":"PZA208"},{"value":"YD8119.18"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12730134"}],"value":"Required for DNA replication. Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery. Required for the chromatin binding of CDC45"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14690591"}],"value":"Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3. Interacts with PSF2"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q12488","intActId":"EBI-22066"},"interactantTwo":{"uniProtKBAccession":"Q01454","geneName":"CTF4","intActId":"EBI-5209"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12488","intActId":"EBI-22066"},"interactantTwo":{"uniProtKBAccession":"P30665","geneName":"MCM4","intActId":"EBI-4326"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12488","intActId":"EBI-22066"},"interactantTwo":{"uniProtKBAccession":"P40359","geneName":"PSF2","intActId":"EBI-25936"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12488","intActId":"EBI-22066"},"interactantTwo":{"uniProtKBAccession":"Q03406","geneName":"SLD5","intActId":"EBI-37437"},"numberOfExperiments":6,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Associates with autonomously replicating sequence (ARS) regions in S phase. This association requires SLD3 and DPB11"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12730134"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 1431 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the GINS1/PSF1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"DNA replication complex GINS protein PSF1","featureId":"PRO_0000219040"},{"type":"Mutagenesis","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"In PSF1-1; temperature-sensitive mutant. Defective in DNA replication. Impaired chromatin binding of CDC45.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12730134"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Helix","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PMN"}]},{"type":"Helix","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7PMK"}]},{"type":"Helix","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Helix","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Turn","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Helix","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Turn","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Beta strand","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9E2X"}]},{"type":"Beta strand","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Beta strand","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Beta strand","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Turn","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Helix","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8KG6"}]},{"type":"Beta strand","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9E2Y"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"12730134","citationType":"journal article","authors":["Takayama Y.","Kamimura Y.","Okawa M.","Muramatsu S.","Sugino A.","Araki H."],"citationCrossReferences":[{"database":"PubMed","id":"12730134"},{"database":"DOI","id":"10.1101/gad.1065903"}],"title":"GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.","publicationDate":"2003","journal":"Genes Dev.","firstPage":"1153","lastPage":"1165","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","FUNCTION","INTERACTION WITH DPB11 AND SLD3","COMPOSITION OF THE GINS COMPLEX","SUBCELLULAR LOCATION","MUTAGENESIS OF ARG-84"]},{"referenceNumber":2,"citation":{"id":"8896275","citationType":"journal article","authors":["Eide L.G.","Sander C.","Prydz H."],"citationCrossReferences":[{"database":"PubMed","id":"8896275"},{"database":"DOI","id":"10.1002/(sici)1097-0061(199609)12:10b<1085::aid-yea9>3.3.co;2-s"}],"title":"Sequencing and analysis of a 35.4 kb region on the right arm of chromosome IV from Saccharomyces cerevisiae reveal 23 open reading frames.","publicationDate":"1996","journal":"Yeast","firstPage":"1085","lastPage":"1090","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"9169867","citationType":"journal article","authors":["Jacq C.","Alt-Moerbe J.","Andre B.","Arnold W.","Bahr A.","Ballesta J.P.G.","Bargues M.","Baron L.","Becker A.","Biteau N.","Bloecker H.","Blugeon C.","Boskovic J.","Brandt P.","Brueckner M.","Buitrago M.J.","Coster F.","Delaveau T.","del Rey F.","Dujon B.","Eide L.G.","Garcia-Cantalejo J.M.","Goffeau A.","Gomez-Peris A.","Granotier C.","Hanemann V.","Hankeln T.","Hoheisel J.D.","Jaeger W.","Jimenez A.","Jonniaux J.-L.","Kraemer C.","Kuester H.","Laamanen P.","Legros Y.","Louis E.J.","Moeller-Rieker S.","Monnet A.","Moro M.","Mueller-Auer S.","Nussbaumer B.","Paricio N.","Paulin L.","Perea J.","Perez-Alonso M.","Perez-Ortin J.E.","Pohl T.M.","Prydz H.","Purnelle B.","Rasmussen S.W.","Remacha M.A.","Revuelta J.L.","Rieger M.","Salom D.","Saluz H.P.","Saiz J.E.","Saren A.-M.","Schaefer M.","Scharfe M.","Schmidt E.R.","Schneider C.","Scholler P.","Schwarz S.","Soler-Mira A.","Urrestarazu L.A.","Verhasselt P.","Vissers S.","Voet M.","Volckaert G.","Wagner G.","Wambutt R.","Wedler E.","Wedler H.","Woelfl S.","Harris D.E.","Bowman S.","Brown D.","Churcher C.M.","Connor R.","Dedman K.","Gentles S.","Hamlin N.","Hunt S.","Jones L.","McDonald S.","Murphy L.D.","Niblett D.","Odell C.","Oliver K.","Rajandream M.A.","Richards C.","Shore L.","Walsh S.V.","Barrell B.G.","Dietrich F.S.","Mulligan J.T.","Allen E.","Araujo R.","Aviles E.","Berno A.","Carpenter J.","Chen E.","Cherry J.M.","Chung E.","Duncan M.","Hunicke-Smith S.","Hyman R.W.","Komp C.","Lashkari D.","Lew H.","Lin D.","Mosedale D.","Nakahara K.","Namath A.","Oefner P.","Oh C.","Petel F.X.","Roberts D.","Schramm S.","Schroeder M.","Shogren T.","Shroff N.","Winant A.","Yelton M.A.","Botstein D.","Davis R.W.","Johnston M.","Andrews S.","Brinkman R.","Cooper J.","Ding H.","Du Z.","Favello A.","Fulton L.","Gattung S.","Greco T.","Hallsworth K.","Hawkins J.","Hillier L.W.","Jier M.","Johnson D.","Johnston L.","Kirsten J.","Kucaba T.","Langston Y.","Latreille P.","Le T.","Mardis E.","Menezes S.","Miller N.","Nhan M.","Pauley A.","Peluso D.","Rifkin L.","Riles L.","Taich A.","Trevaskis E.","Vignati D.","Wilcox L.","Wohldman P.","Vaudin M.","Wilson R.","Waterston R.","Albermann K.","Hani J.","Heumann K.","Kleine K.","Mewes H.-W.","Zollner A.","Zaccaria P."],"citationCrossReferences":[{"database":"PubMed","id":"9169867"},{"database":"DOI","id":"10.1038/387s075"}],"title":"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.","publicationDate":"1997","journal":"Nature","firstPage":"75","lastPage":"78","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"14690591","citationType":"journal article","authors":["Hazbun T.R.","Malmstroem L.","Anderson S.","Graczyk B.J.","Fox B.","Riffle M.","Sundin B.A.","Aranda J.D.","McDonald W.H.","Chiu C.-H.","Snydsman B.E.","Bradley P.","Muller E.G.D.","Fields S.","Baker D.","Yates J.R. III","Davis T.N."],"citationCrossReferences":[{"database":"PubMed","id":"14690591"},{"database":"DOI","id":"10.1016/s1097-2765(03)00476-3"}],"title":"Assigning function to yeast proteins by integration of technologies.","publicationDate":"2003","journal":"Mol. Cell","firstPage":"1353","lastPage":"1365","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","INTERACTION WITH PSF2"]},{"referenceNumber":7,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X95966","properties":[{"key":"ProteinId","value":"CAA65205.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z74309","properties":[{"key":"ProteinId","value":"CAA98833.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z48008","properties":[{"key":"ProteinId","value":"CAA88073.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY557650","properties":[{"key":"ProteinId","value":"AAS55976.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006938","properties":[{"key":"ProteinId","value":"DAA11859.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S50994","properties":[{"key":"EntryName","value":"S50994"}]},{"database":"RefSeq","id":"NP_010296.3","properties":[{"key":"NucleotideSequenceId","value":"NM_001180321.3"}]},{"database":"PDB","id":"3JC5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.70 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"3JC6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"3JC7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.80 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"5U8S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.10 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"5U8T","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.90 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"6HV9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.98 A"},{"key":"Chains","value":"C=1-208"}]},{"database":"PDB","id":"6PTJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"6PTN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.80 A"},{"key":"Chains","value":"A/a=1-208"}]},{"database":"PDB","id":"6PTO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.00 A"},{"key":"Chains","value":"A/a/n=1-208"}]},{"database":"PDB","id":"6SKL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"6U0M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"7PMK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"7PMN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"8B9A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"C=1-208"}]},{"database":"PDB","id":"8B9B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"C=1-208"}]},{"database":"PDB","id":"8B9C","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.60 A"},{"key":"Chains","value":"C=1-208"}]},{"database":"PDB","id":"8KG6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.07 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"8KG8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.23 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"8KG9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.52 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"8P5E","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"H=1-208"}]},{"database":"PDB","id":"8P62","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"H=1-208"}]},{"database":"PDB","id":"8P63","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"H=1-208"}]},{"database":"PDB","id":"8W7M","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.12 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"8W7S","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.39 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"8XGC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"9E2W","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"9E2X","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDB","id":"9E2Y","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-208"}]},{"database":"PDBsum","id":"3JC5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3JC6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3JC7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5U8S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5U8T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6HV9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PTJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PTN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PTO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SKL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6U0M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7PMK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7PMN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8B9A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8B9B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8B9C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8KG6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8KG8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8KG9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8P5E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8P62","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8P63","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8W7M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8W7S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XGC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E2W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E2X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E2Y","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q12488","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10227","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13539","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-15924","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17449","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17458","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17459","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20471","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20472","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20473","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20607","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37211","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37213","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37215","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37343","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37345","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38317","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47470","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47471","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47472","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-8518","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-8519","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q12488","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"32064","properties":[{"key":"Interactions","value":"297"}]},{"database":"ComplexPortal","id":"CPX-1641","properties":[{"key":"EntryName","value":"GINS complex"}]},{"database":"DIP","id":"DIP-1812N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q12488","properties":[{"key":"Number of interactors","value":"541"}]},{"database":"IntAct","id":"Q12488","properties":[{"key":"Interactions","value":"32"}]},{"database":"MINT","id":"Q12488","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YDR013W","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q12488","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YDR013W","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q12488","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YDR013W_mRNA","properties":[{"key":"ProteinId","value":"YDR013W"},{"key":"GeneId","value":"YDR013W"}]},{"database":"GeneID","id":"851576","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"sce:YDR013W","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000002420","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000002420","properties":[{"key":"GeneName","value":"PSF1"}]},{"database":"VEuPathDB","id":"FungiDB:YDR013W","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3303","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_079191_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q12488","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MFCEKAT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10252587at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-29632-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-SCE-176974","properties":[{"key":"PathwayName","value":"Unwinding of DNA"}]},{"database":"BioGRID-ORCS","id":"851576","properties":[{"key":"hits","value":"0 hits in 10 CRISPR screens"}]},{"database":"PRO","id":"PR:Q12488","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome IV"}]},{"database":"RNAct","id":"Q12488","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0071162","properties":[{"key":"GoTerm","value":"C:CMG complex"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26524492"}]},{"database":"GO","id":"GO:0031261","properties":[{"key":"GoTerm","value":"C:DNA replication preinitiation complex"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12730134"}]},{"database":"GO","id":"GO:0000811","properties":[{"key":"GoTerm","value":"C:GINS complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12730134"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12768207"}]},{"database":"GO","id":"GO:0043596","properties":[{"key":"GoTerm","value":"C:nuclear replication fork"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25313033"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24628792"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25313033"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25313033"}]},{"database":"GO","id":"GO:1902983","properties":[{"key":"GoTerm","value":"P:DNA strand elongation involved in mitotic DNA replication"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006261","properties":[{"key":"GoTerm","value":"P:DNA-templated DNA replication"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12730134"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12768207"}]},{"database":"GO","id":"GO:0000727","properties":[{"key":"GoTerm","value":"P:double-strand break repair via break-induced replication"},{"key":"GoEvidenceType","value":"IMP:SGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20516198"}]},{"database":"CDD","id":"cd11710","properties":[{"key":"EntryName","value":"GINS_A_psf1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21696","properties":[{"key":"EntryName","value":"GINS_B_Psf1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.1030:FF:000003","properties":[{"key":"EntryName","value":"DNA replication complex GINS protein PSF1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1030","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR021151","properties":[{"key":"EntryName","value":"GINS_A"}]},{"database":"InterPro","id":"IPR036224","properties":[{"key":"EntryName","value":"GINS_bundle-like_dom_sf"}]},{"database":"InterPro","id":"IPR005339","properties":[{"key":"EntryName","value":"GINS_Psf1"}]},{"database":"InterPro","id":"IPR056783","properties":[{"key":"EntryName","value":"PSF1_C"}]},{"database":"PANTHER","id":"PTHR12914:SF2","properties":[{"key":"EntryName","value":"DNA REPLICATION COMPLEX GINS PROTEIN PSF1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12914","properties":[{"key":"EntryName","value":"PARTNER OF SLD5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24997","properties":[{"key":"EntryName","value":"PSF1_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05916","properties":[{"key":"EntryName","value":"Sld5"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF158573","properties":[{"key":"EntryName","value":"GINS helical bundle-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQLGMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDTNNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGVFNLIKDSQFFVRQSDVERLIQQGYLQKI","length":208,"molWeight":24204,"crc64":"4667D8152C1AB5B4","md5":"7A8739A3884AD3AD6F4EDC3420926719"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":4,"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Mutagenesis":1,"Helix":7,"Beta strand":7,"Turn":3},"uniParcId":"UPI000013A7CD"}}