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Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes: during this process, GCN1 acts as a chaperone to facilitate delivery of uncharged tRNAs that enter the A-site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2). eIF-2-alpha/SUI2 phosphorylation converts eIF-2-alpha/SUI2 into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator GCN4, and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P33892"}],"value":"Interacts (via N- and C-terminus) with gcn2 (via N-terminal RWD domain); this interaction stimulates gcn2 kinase activity in a gcn20-dependent manner in response to amino acid starvation. Interacts (via C-terminus) with gcn20 (via N-terminus); this interaction stimulates gcn2 kinase activity in response to amino acid starvation. The gcn1-gcn20 complex interacts with gcn2 on translating ribosomes in amino acid-starved cells; gcn1 may bind near the ribosomal A-site and promotes the transfer of uncharged tRNAs from the A-site to the tRNA-binding domain in gcn2 for its subsequent kinase activation, and hence allowing fil1 translational activation and derepression of amino acid biosynthetic genes. Interacts (via C-terminus) with yih1 (via N-terminus); this interaction reduces the gcn1-gcn20 complex formation and prevents the interaction of gcn1 with gcn2 and gcn2 kinase activation in amino acid-starved cells"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P33892"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P33892"}],"value":"The EF3-like region is necessary and sufficient for interaction with GCN20"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P33892"}],"value":"The RWDBD (RWD-binding domain) region mediates binding to RWD domain-containing proteins, such as GCN2"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the GCN1 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LOCATION":1,"DOMAIN":2,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Repeat":41,"Region":2},"uniParcId":"UPI000013A146"}}