{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q0WPN8","secondaryAccessions":["Q501A0","Q9FHQ4"],"uniProtkbId":"PDLP7_ARATH","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-09-05","entryVersion":100,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Plasmodesmata-located protein 7"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20886105"}],"value":"PD-located protein 7"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11402176"}],"value":"Cysteine-rich repeat secretory protein 60"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20886105"}],"value":"PDLP7"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11402176"}],"value":"CRRSP60"}],"orderedLocusNames":[{"value":"At5g37660"}],"orfNames":[{"value":"K12B20.12"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8GXV7"}],"value":"Modulates cell-to-cell trafficking"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20886105"}],"value":"(Microbial infection) Interacts with Grapevine fanleaf virus (GFLV) 2B-MP"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886105"}],"value":"Co-localizes with the Grapevine fanleaf virus (GFLV) 2B-MP at the base of tubules within modified plasmodesmata"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8GXV7"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8GXV7"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886105"}],"value":"Cell junction, plasmodesma","id":"SL-0208"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q0WPN8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q0WPN8-2"],"sequenceIds":["VSP_027133","VSP_027134"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19704520"}],"value":"Highly expressed in lateral root and elongation zone"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the cysteine-rich repeat secretory protein family. Plasmodesmata-located proteins (PDLD) subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"PDLPs were initially named Cysteine-rich secretory proteins based on a classification work that failed to predict the transmembrane region at the C-terminus (PubMed:11402176). However, it was later shown that PDLPs are membrane proteins"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAB08312.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Plasmodesmata-located protein 7","featureId":"PRO_0000296173"},{"type":"Topological domain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8GXV7"}]},{"type":"Transmembrane","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8GXV7"}]},{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Gnk2-homologous 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Domain","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Gnk2-homologous 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Region","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Necessary and sufficient for plasmodesmal targeting","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8GXV7"}]},{"type":"Disulfide bond","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Disulfide bond","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Disulfide bond","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Disulfide bond","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Disulfide bond","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Disulfide bond","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00806"}]},{"type":"Alternative sequence","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_027133","alternativeSequence":{"originalSequence":"D","alternativeSequences":["K"]}},{"type":"Alternative sequence","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_027134","alternativeSequence":{}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"10470850","citationType":"journal article","authors":["Kaneko T.","Katoh T.","Sato S.","Nakamura Y.","Asamizu E.","Kotani H.","Miyajima N.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10470850"},{"database":"DOI","id":"10.1093/dnares/6.3.183"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence features of the regions of 1,011,550 bp covered by seventeen P1 and TAC clones.","publicationDate":"1999","journal":"DNA Res.","firstPage":"183","lastPage":"195","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-9LRAQ4G4FB5E1","citationType":"submission","authors":["Shinn P.","Chen H.","Cheuk R.F.","Kim C.J.","Ecker J.R."],"title":"Arabidopsis cDNA clones.","publicationDate":"MAY-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-1ND7IVR87IF4I","citationType":"submission","authors":["Totoki Y.","Seki M.","Ishida J.","Nakajima M.","Enju A.","Kamiya A.","Narusaka M.","Shin-i T.","Nakagawa M.","Sakamoto N.","Oishi K.","Kohara Y.","Kobayashi M.","Toyoda A.","Sakaki Y.","Sakurai T.","Iida K.","Akiyama K.","Satou M.","Toyoda T.","Konagaya A.","Carninci P.","Kawai J.","Hayashizaki Y.","Shinozaki K."],"title":"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.","publicationDate":"JUL-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"11402176","citationType":"journal article","authors":["Chen Z."],"citationCrossReferences":[{"database":"PubMed","id":"11402176"},{"database":"DOI","id":"10.1104/pp.126.2.473"}],"title":"A superfamily of proteins with novel cysteine-rich repeats.","publicationDate":"2001","journal":"Plant Physiol.","firstPage":"473","lastPage":"476","volume":"126"},"referencePositions":["GENE FAMILY ORGANIZATION","NOMENCLATURE","CAUTION"]},{"referenceNumber":7,"citation":{"id":"19704520","citationType":"journal article","authors":["Bayer E.","Thomas C.","Maule A."],"citationCrossReferences":[{"database":"PubMed","id":"19704520"},{"database":"DOI","id":"10.4161/psb.3.10.6020"}],"title":"Symplastic domains in the Arabidopsis shoot apical meristem correlate with PDLP1 expression patterns.","publicationDate":"2008","journal":"Plant Signal. Behav.","firstPage":"853","lastPage":"855","volume":"3"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":8,"citation":{"id":"20886105","citationType":"journal article","authors":["Amari K.","Boutant E.","Hofmann C.","Schmitt-Keichinger C.","Fernandez-Calvino L.","Didier P.","Lerich A.","Mutterer J.","Thomas C.L.","Heinlein M.","Mely Y.","Maule A.J.","Ritzenthaler C."],"citationCrossReferences":[{"database":"PubMed","id":"20886105"},{"database":"DOI","id":"10.1371/journal.ppat.1001119"}],"title":"A family of plasmodesmal proteins with receptor-like properties for plant viral movement proteins.","publicationDate":"2010","journal":"PLoS Pathog.","firstPage":"E1001119","lastPage":"E1001119","volume":"6"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH GRAPEVINE FANLEAF VIRUS 2B-MP PROTEIN"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB018107","properties":[{"key":"ProteinId","value":"BAB08312.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED94215.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED94216.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7054284.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7054285.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT022067","properties":[{"key":"ProteinId","value":"AAY27054.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK229025","properties":[{"key":"ProteinId","value":"BAF00911.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001078675.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001085206.1"}],"isoformId":"Q0WPN8-1"},{"database":"RefSeq","id":"NP_198582.2","properties":[{"key":"NucleotideSequenceId","value":"NM_123125.4"}],"isoformId":"Q0WPN8-2"},{"database":"AlphaFoldDB","id":"Q0WPN8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q0WPN8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"18995","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q0WPN8","properties":[{"key":"Number of interactors","value":"37"}]},{"database":"IntAct","id":"Q0WPN8","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"3702.Q0WPN8","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.I.2.1.1","properties":[{"key":"FamilyName","value":"the plant plasmodesmata (ppd) family"}]},{"database":"PaxDb","id":"3702-Q0WPN8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"224406","properties":[{"key":"Description","value":"-"}],"isoformId":"Q0WPN8-1"},{"database":"GeneID","id":"833744","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G37660","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G37660","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G37660","properties":[{"key":"GeneName","value":"PDLP7"}]},{"database":"eggNOG","id":"ENOG502QTDS","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q0WPN8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AICGGCV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"Q0WPN8","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q0WPN8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0009506","properties":[{"key":"GoTerm","value":"C:plasmodesma"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18215111"}]},{"database":"GO","id":"GO:0001872","properties":[{"key":"GoTerm","value":"F:(1->3)-beta-D-glucan binding"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38735789"}]},{"database":"GO","id":"GO:0009615","properties":[{"key":"GoTerm","value":"P:response to virus"},{"key":"GoEvidenceType","value":"IEP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"38735789"}]},{"database":"CDD","id":"cd23509","properties":[{"key":"EntryName","value":"Gnk2-like"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"3.30.430.20:FF:000001","properties":[{"key":"EntryName","value":"cysteine-rich repeat secretory protein 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.430.20:FF:000020","properties":[{"key":"EntryName","value":"Cysteine-rich repeat secretory protein 60"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.430.20","properties":[{"key":"EntryName","value":"Gnk2 domain, C-X8-C-X2-C motif"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR051378","properties":[{"key":"EntryName","value":"Cell2Cell_Antifungal"}]},{"database":"InterPro","id":"IPR002902","properties":[{"key":"EntryName","value":"GNK2"}]},{"database":"InterPro","id":"IPR038408","properties":[{"key":"EntryName","value":"GNK2_sf"}]},{"database":"PANTHER","id":"PTHR32080","properties":[{"key":"EntryName","value":"ANTIFUNGAL PROTEIN GINKBILOBIN-2-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32080:SF3","properties":[{"key":"EntryName","value":"PLASMODESMATA-LOCATED PROTEIN 7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01657","properties":[{"key":"EntryName","value":"Stress-antifung"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51473","properties":[{"key":"EntryName","value":"GNK2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MPMAKLRNIIKTLSIFFFLIAATAPSLSSATSATDTFVFGGCSQQKFSPASAYESNLNSLLTSLVNSATYSSYNNFTIMGSSSSDTARGLFQCRGDLSMPDCATCVARAVSQVGPLCPFTCGGALQLAGCYIKYDNISFLGQEDKTVVLKKCGSSEGYNTDGISRRDAVLTELVNGGGYFRAGGSGDVQGMGQCVGDLTVSECQDCLGTAIGRLKNDCGTAVFGDMFLAKCYARYSTDGAQHYAKSHNYKTNYGGEKTFAIIIGLLAAVVLLIIFLLFLRGVCSRGGDFSILHSFTLI","length":298,"molWeight":31603,"crc64":"7C47946C0C82704A","md5":"8B9E523C16424695EAC77B187E0E185C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":2,"Region":1,"Disulfide bond":6,"Alternative sequence":2},"uniParcId":"UPI0000DB5373"}}