{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q0VCP9","uniProtkbId":"CC149_BOVIN","entryAudit":{"firstPublicDate":"2008-07-22","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2006-09-05","entryVersion":78,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Bos taurus","commonName":"Bovine","taxonId":9913,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Laurasiatheria","Artiodactyla","Ruminantia","Pecora","Bovidae","Bovinae","Bos"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Coiled-coil domain-containing protein 149"}}},"genes":[{"geneName":{"value":"CCDC149"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CCDC149 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Coiled-coil domain-containing protein 149","featureId":"PRO_0000344208"},{"type":"Transmembrane","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-1L3I87URMCQQC","citationType":"submission","authoringGroup":["NIH - Mammalian Gene Collection (MGC) project"],"publicationDate":"AUG-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Hereford","type":"STRAIN"},{"value":"Fetal liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC120065","properties":[{"key":"ProteinId","value":"AAI20066.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q0VCP9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q0VCP9","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9913.ENSBTAP00000069473","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9913-ENSBTAP00000069473","properties":[{"key":"Description","value":"-"}]},{"database":"VGNC","id":"VGNC:26855","properties":[{"key":"GeneName","value":"CCDC149"}]},{"database":"eggNOG","id":"KOG4687","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_016190_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q0VCP9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5917629at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000009136","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"Gene3D","id":"1.10.287.1490","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019179","properties":[{"key":"EntryName","value":"CC149"}]},{"database":"PANTHER","id":"PTHR21682","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 149"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21682:SF2","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 149"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09789","properties":[{"key":"EntryName","value":"CC149"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEEIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQNKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGLSYNVSIGFGSMFFLKYLCLWLIAVH","length":319,"molWeight":36673,"crc64":"C8AF487FE7D6BD8E","md5":"06451E3AE68DBFA98DEB1474DB54B67C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Coiled coil":2},"uniParcId":"UPI0000DBDCB1"}}