{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q0JF48","secondaryAccessions":["Q6VY02","Q7XSN0"],"uniProtkbId":"EMF2A_ORYSJ","entryAudit":{"firstPublicDate":"2018-06-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-03","entryVersion":109,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Oryza sativa subsp. japonica","commonName":"Rice","taxonId":39947,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Poales","Poaceae","BOP clade","Oryzoideae","Oryzeae","Oryzinae","Oryza","Oryza sativa"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Polycomb group protein EMF2A"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19825651"}],"value":"OsEMF2A"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Polycomb group protein EMBRYONIC FLOWER 2B"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19825651"}],"value":"EMF2A"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAS87849.1"}],"value":"Os04g0162100"},{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"LOC_Os04g08034"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"EEE60482.1"}],"value":"OsJ_13761"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"CAE01874.2"}],"value":"OSJNBb0028M18.7"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q69KN0"}],"value":"Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They act via the methylation of histones, rendering chromatin heritably changed in its expressibility"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q69KN0"}],"value":"Component of the polycomb repressive complex 2 (PRC2), which methylates 'Lys-27' residues of histone H3 (H3K27me3), leading to transcriptional repression of the affected target gene"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16753820"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19825651"}],"value":"Widely expressed (PubMed:19825651). Highly expressed in shoot apical meristem and inflorescence meristem. Expressed in roots, leaves and immature seeds (PubMed:16753820)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"CAE01874.2","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"EEE60482.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"Polycomb group protein EMF2A","featureId":"PRO_0000444463"},{"type":"Zinc finger","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"VEFS-box","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ84239","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":618,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ84239","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"16753820","citationType":"journal article","authors":["Li K.","Yang J.","Liu J.","Du X.","Wei C.","Su W.","He G.","Zhang Q.","Hong F.","Qian X."],"citationCrossReferences":[{"database":"PubMed","id":"16753820"},{"database":"DOI","id":"10.1080/10425170500151961"}],"title":"Cloning, characterization and tissue-specific expression of a cDNA encoding a novel EMBRYONIC FLOWER 2 gene (OsEMF2) in Oryza sativa.","publicationDate":"2006","journal":"DNA Seq.","firstPage":"74","lastPage":"78","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Leaf","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"12447439","citationType":"journal article","authors":["Feng Q.","Zhang Y.","Hao P.","Wang S.","Fu G.","Huang Y.","Li Y.","Zhu J.","Liu Y.","Hu X.","Jia P.","Zhang Y.","Zhao Q.","Ying K.","Yu S.","Tang Y.","Weng Q.","Zhang L.","Lu Y.","Mu J.","Lu Y.","Zhang L.S.","Yu Z.","Fan D.","Liu X.","Lu T.","Li C.","Wu Y.","Sun T.","Lei H.","Li T.","Hu H.","Guan J.","Wu M.","Zhang R.","Zhou B.","Chen Z.","Chen L.","Jin Z.","Wang R.","Yin H.","Cai Z.","Ren S.","Lv G.","Gu W.","Zhu G.","Tu Y.","Jia J.","Zhang Y.","Chen J.","Kang H.","Chen X.","Shao C.","Sun Y.","Hu Q.","Zhang X.","Zhang W.","Wang L.","Ding C.","Sheng H.","Gu J.","Chen S.","Ni L.","Zhu F.","Chen W.","Lan L.","Lai Y.","Cheng Z.","Gu M.","Jiang J.","Li J.","Hong G.","Xue Y.","Han B."],"citationCrossReferences":[{"database":"PubMed","id":"12447439"},{"database":"DOI","id":"10.1038/nature01183"}],"title":"Sequence and analysis of rice chromosome 4.","publicationDate":"2002","journal":"Nature","firstPage":"316","lastPage":"320","volume":"420"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"16100779","citationType":"journal article","authoringGroup":["International rice genome sequencing project (IRGSP)"],"citationCrossReferences":[{"database":"PubMed","id":"16100779"},{"database":"DOI","id":"10.1038/nature03895"}],"title":"The map-based sequence of the rice genome.","publicationDate":"2005","journal":"Nature","firstPage":"793","lastPage":"800","volume":"436"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"18089549","citationType":"journal article","authoringGroup":["The rice annotation project (RAP)"],"citationCrossReferences":[{"database":"PubMed","id":"18089549"},{"database":"DOI","id":"10.1093/nar/gkm978"}],"title":"The rice annotation project database (RAP-DB): 2008 update.","publicationDate":"2008","journal":"Nucleic Acids Res.","firstPage":"D1028","lastPage":"D1033","volume":"36"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"24280374","citationType":"journal article","authors":["Kawahara Y.","de la Bastide M.","Hamilton J.P.","Kanamori H.","McCombie W.R.","Ouyang S.","Schwartz D.C.","Tanaka T.","Wu J.","Zhou S.","Childs K.L.","Davidson R.M.","Lin H.","Quesada-Ocampo L.","Vaillancourt B.","Sakai H.","Lee S.S.","Kim J.","Numa H.","Itoh T.","Buell C.R.","Matsumoto T."],"citationCrossReferences":[{"database":"PubMed","id":"24280374"},{"database":"DOI","id":"10.1186/1939-8433-6-4"}],"title":"Improvement of the Oryza sativa Nipponbare reference genome using next generation sequence and optical map data.","publicationDate":"2013","journal":"Rice","firstPage":"4","lastPage":"4","volume":"6"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"15685292","citationType":"journal article","authors":["Yu J.","Wang J.","Lin W.","Li S.","Li H.","Zhou J.","Ni P.","Dong W.","Hu S.","Zeng C.","Zhang J.","Zhang Y.","Li R.","Xu Z.","Li S.","Li X.","Zheng H.","Cong L.","Lin L.","Yin J.","Geng J.","Li G.","Shi J.","Liu J.","Lv H.","Li J.","Wang J.","Deng Y.","Ran L.","Shi X.","Wang X.","Wu Q.","Li C.","Ren X.","Wang J.","Wang X.","Li D.","Liu D.","Zhang X.","Ji Z.","Zhao W.","Sun Y.","Zhang Z.","Bao J.","Han Y.","Dong L.","Ji J.","Chen P.","Wu S.","Liu J.","Xiao Y.","Bu D.","Tan J.","Yang L.","Ye C.","Zhang J.","Xu J.","Zhou Y.","Yu Y.","Zhang B.","Zhuang S.","Wei H.","Liu B.","Lei M.","Yu H.","Li Y.","Xu H.","Wei S.","He X.","Fang L.","Zhang Z.","Zhang Y.","Huang X.","Su Z.","Tong W.","Li J.","Tong Z.","Li S.","Ye J.","Wang L.","Fang L.","Lei T.","Chen C.-S.","Chen H.-C.","Xu Z.","Li H.","Huang H.","Zhang F.","Xu H.","Li N.","Zhao C.","Li S.","Dong L.","Huang Y.","Li L.","Xi Y.","Qi Q.","Li W.","Zhang B.","Hu W.","Zhang Y.","Tian X.","Jiao Y.","Liang X.","Jin J.","Gao L.","Zheng W.","Hao B.","Liu S.-M.","Wang W.","Yuan L.","Cao M.","McDermott J.","Samudrala R.","Wang J.","Wong G.K.-S.","Yang H."],"citationCrossReferences":[{"database":"PubMed","id":"15685292"},{"database":"DOI","id":"10.1371/journal.pbio.0030038"}],"title":"The genomes of Oryza sativa: a history of duplications.","publicationDate":"2005","journal":"PLoS Biol.","firstPage":"266","lastPage":"281","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"19825651","citationType":"journal article","authors":["Luo M.","Platten D.","Chaudhury A.","Peacock W.J.","Dennis E.S."],"citationCrossReferences":[{"database":"PubMed","id":"19825651"},{"database":"DOI","id":"10.1093/mp/ssp036"}],"title":"Expression, imprinting, and evolution of rice homologs of the polycomb group genes.","publicationDate":"2009","journal":"Mol. Plant","firstPage":"711","lastPage":"723","volume":"2"},"referencePositions":["TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY321106","properties":[{"key":"ProteinId","value":"AAQ84239.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL606654","properties":[{"key":"ProteinId","value":"CAE01874.2"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP008210","properties":[{"key":"ProteinId","value":"BAF14039.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP014960","properties":[{"key":"ProteinId","value":"BAS87849.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CM000141","properties":[{"key":"ProteinId","value":"EEE60482.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q0JF48","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q0JF48","properties":[{"key":"Number of interactors","value":"801"}]},{"database":"STRING","id":"39947.Q0JF48","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"39947-Q0JF48","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblPlants","id":"Os04t0162100-01","properties":[{"key":"ProteinId","value":"Os04t0162100-01"},{"key":"GeneId","value":"Os04g0162100"}]},{"database":"Gramene","id":"Os04t0162100-01","properties":[{"key":"ProteinId","value":"Os04t0162100-01"},{"key":"GeneId","value":"Os04g0162100"}]},{"database":"KEGG","id":"dosa:Os04g0162100","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"osa:4335036","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2350","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_022782_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q0JF48","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QRHAIKK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"166746at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000059680","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"ExpressionAtlas","id":"Q0JF48","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031490","properties":[{"key":"GoTerm","value":"F:chromatin DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006325","properties":[{"key":"GoTerm","value":"P:chromatin organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd21553","properties":[{"key":"EntryName","value":"VEFS-box_EMF2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21749","properties":[{"key":"EntryName","value":"ZnB-Zn_EMF2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR056068","properties":[{"key":"EntryName","value":"EMF2-like_DUF7651"}]},{"database":"InterPro","id":"IPR019135","properties":[{"key":"EntryName","value":"Polycomb_protein_VEFS-Box"}]},{"database":"InterPro","id":"IPR057540","properties":[{"key":"EntryName","value":"Znf_SUZ12"}]},{"database":"PANTHER","id":"PTHR22597","properties":[{"key":"EntryName","value":"POLYCOMB GROUP PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22597:SF0","properties":[{"key":"EntryName","value":"POLYCOMB PROTEIN SUZ12"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24663","properties":[{"key":"EntryName","value":"DUF7651"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09733","properties":[{"key":"EntryName","value":"VEFS-Box"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23320","properties":[{"key":"EntryName","value":"Zn_SUZ12"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00028","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLPLTDHDAVNTGCEFDCQRSSDQMCCEHSVAQFSSDQQLNPEENLALYCKPLELYNFIRHRAIENPPYLQRCLLYKIRAKQKKRIQITISLPGSNNKELQAQNIFPLYVLFARPTSNVPIEGHSPIYRFSQARLLTSFNDSGNNDRAEATFVIPDLETLIATQAYGLTFILVSRGTKKNKGRTGQNLCENDCSEKHVDYSSLRKLAGKCFWGKIPITLLNSSLETCADLILGHIVESPISICMSPGYLEPTFLEHDNCLSFCSRKADAMVPYQLQVKVSAAEAGAKDILKSPYNSFSYSDVPPSLLLRIVRLRVGNVLFNYKNTQMSEVTEDFTCPFCLVRCGNFKGLECHMTSSHDLFHYEFWISEDYQAVNVTLKKDNMRTEFVAAEVDNSHRIFYYRSRFKKSRTEILPVARADAHIMESGSPEETQAESEDDVQEENENALIDDSKKLHGSNHSQSEFLAFGKSRKLSANRADPRNRLLLQKRQFIHSHKAQPMTFEEVLSDNDSEDEVDDDIADLEDRRMLDDFVDVTKDEKRIMHMWNSFIRKQSILADSHVPWACEAFSRHHGEELLENSALLWGWRMFMIKLWNHSLLSARTMDTCNRILDDIKNERSDPKKQ","length":624,"molWeight":71547,"crc64":"0D8309FE55B0707E","md5":"E031E115A8038E97FDB00E6DCB73B200"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Zinc finger":1,"Region":2,"Compositional bias":1,"Sequence conflict":2},"uniParcId":"UPI0000DD8F3C"}}