{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q09644","uniProtkbId":"NDUF7_CAEEL","entryAudit":{"firstPublicDate":"2008-01-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-09-11","entryVersion":129,"sequenceVersion":4},"annotationScore":2.0,"organism":{"scientificName":"Caenorhabditis elegans","taxonId":6239,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Nematoda","Chromadorea","Rhabditida","Rhabditina","Rhabditomorpha","Rhabditoidea","Rhabditidae","Peloderinae","Caenorhabditis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7L592"}],"value":"Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7L592"}],"value":"2.1.1.320"}]},"alternativeNames":[{"fullName":{"value":"NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 homolog"}},{"fullName":{"value":"Protein midA homolog"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"WormBase","id":"ZK1128.1"}],"value":"nuaf-7"},"orfNames":[{"value":"ZK1128.1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7L592"}],"value":"Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48108"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:11992"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:88221"}],"ecNumber":"2.1.1.320","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7L592"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7L592"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the NDUFAF7 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial","featureId":"PRO_0000315678"}],"keywords":[{"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"9851916","citationType":"journal article","authoringGroup":["The C. elegans sequencing consortium"],"citationCrossReferences":[{"database":"PubMed","id":"9851916"},{"database":"DOI","id":"10.1126/science.282.5396.2012"}],"title":"Genome sequence of the nematode C. elegans: a platform for investigating biology.","publicationDate":"1998","journal":"Science","firstPage":"2012","lastPage":"2018","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Bristol N2","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX284603","properties":[{"key":"ProteinId","value":"CAA87427.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_499246.2","properties":[{"key":"NucleotideSequenceId","value":"NM_066845.8"}]},{"database":"AlphaFoldDB","id":"Q09644","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q09644","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"56689","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q09644","properties":[{"key":"Number of interactors","value":"2829"}]},{"database":"STRING","id":"6239.ZK1128.1.1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"6239-ZK1128.1.1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q09644","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblMetazoa","id":"ZK1128.1.1","properties":[{"key":"ProteinId","value":"ZK1128.1.1"},{"key":"GeneId","value":"WBGene00014227"}]},{"database":"GeneID","id":"259527","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cel:CELE_ZK1128.1","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"ZK1128.1.1","properties":[{"key":"OrganismName","value":"c. elegans"}]},{"database":"AGR","id":"WB:WBGene00014227","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"259527","properties":[{"key":"Description","value":"-"}]},{"database":"WormBase","id":"ZK1128.1","properties":[{"key":"ProteinId","value":"CE41493"},{"key":"GeneId","value":"WBGene00014227"},{"key":"GeneName","value":"nuaf-7"}]},{"database":"eggNOG","id":"KOG2901","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_024840_3_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q09644","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YYHPQRN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"438553at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q09644","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-CEL-6799198","properties":[{"key":"PathwayName","value":"Complex I biogenesis"}]},{"database":"PRO","id":"PR:Q09644","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001940","properties":[{"key":"Component","value":"Chromosome III"}]},{"database":"Bgee","id":"WBGene00014227","properties":[{"key":"ExpressionPatterns","value":"Expressed in germ line (C elegans) and 4 other cell types or tissues"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035243","properties":[{"key":"GoTerm","value":"F:protein-arginine omega-N symmetric methyltransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032981","properties":[{"key":"GoTerm","value":"P:mitochondrial respiratory chain complex I assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"FunFam","id":"3.40.50.12710:FF:000017","properties":[{"key":"EntryName","value":"Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.12710","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003788","properties":[{"key":"EntryName","value":"NDUFAF7"}]},{"database":"InterPro","id":"IPR038375","properties":[{"key":"EntryName","value":"NDUFAF7_sf"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR12049","properties":[{"key":"EntryName","value":"PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12049:SF7","properties":[{"key":"EntryName","value":"PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02636","properties":[{"key":"EntryName","value":"Methyltransf_28"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSLRVQNILINSLRQYSKQILKPPGYASPEKTNHLKKFLVDKIRVSGPITVAEYMKTCVSAPLVGYYGQFSKDQKVFGAKGDFITSPELTQLFGEMIGVWVFHELANTGHKGSWQLVELGPGRAQLMNDVLNALAKFNDKDVSVHLVETSDALIDEQEKSLCIYTSKNSIDTPFIRKNKTRTGVNIYWYKSIDDIPDGFTVFIGNEFLDALPIHQFHKSGDSWNEVYVNLTKDGDLCFMKSKGENLHTKGLIPSAIRDDSSRVTWECSPESGTVVNQIVDRITTFGGFSLLVDYGHDGSRNTHSFRAYKNHKQVDTLENPGLADLTADVDFGYLSTLVKDRVVIYGPNEQREFLAQLGIEHRLRRLLQVCKDRKQQEQLIESYNMLMGDMGLKFKAWALFPKTLEFILEQRGGPAGFSAKKKTTEN","length":426,"molWeight":48107,"crc64":"EA99D7D692679D1A","md5":"5AD1F11B97E161D1CBC0CE3C39A74310"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI000159684A"}}