{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q08AM6","secondaryAccessions":["B3KPJ5","B3KSM8","Q13174","Q6IA12","Q7L4Y1","Q9BW96","Q9H6V6"],"uniProtkbId":"VAC14_HUMAN","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-31","entryVersion":162,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein VAC14 homolog"}},"alternativeNames":[{"fullName":{"value":"Tax1-binding protein 2"}}]},"genes":[{"geneName":{"value":"VAC14"},"synonyms":[{"value":"TAX1BP2"},{"value":"TRX"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15542851"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17556371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33098764"}],"value":"Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17161399"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17556371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18950639"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33098764"}],"value":"Forms pentamers (PubMed:18950639, PubMed:33098764). Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities (PubMed:17556371, PubMed:18950639, PubMed:33098764). Interacts with NOS1 (PubMed:17161399)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8611628"}],"value":"(Microbial infection) Interacts with HTLV-1 Tax"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q8NFV4-4","geneName":"ABHD11","intActId":"EBI-12318443"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q9NUB1","geneName":"ACSS1","intActId":"EBI-10313831"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q5BKX5-3","geneName":"ACTMAP","intActId":"EBI-11976299"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"P48728-4","geneName":"AMT","intActId":"EBI-14394829"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q03989","geneName":"ARID5A","intActId":"EBI-948603"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q8WXK3","geneName":"ASB13","intActId":"EBI-707573"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q8WXK3-2","geneName":"ASB13","intActId":"EBI-12015080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"P13637","geneName":"ATP1A3","intActId":"EBI-948169"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z3D2","geneName":"BCL2L1","intActId":"EBI-16431449"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"O14503","geneName":"BHLHE40","intActId":"EBI-711810"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q9H0W9","geneName":"C11orf54","intActId":"EBI-740204"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q9H0W9-3","geneName":"C11orf54","intActId":"EBI-12108466"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q53TS8","geneName":"C2CD6","intActId":"EBI-739879"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q8N1A6","geneName":"C4orf33","intActId":"EBI-10264911"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"P29466","geneName":"CASP1","intActId":"EBI-516667"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"P29466-3","geneName":"CASP1","intActId":"EBI-12248206"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q9NNX6","geneName":"CD209","intActId":"EBI-9257341"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q9NNX6-10","geneName":"CD209","intActId":"EBI-12300031"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"Q8N9R6","geneName":"CDRT4","intActId":"EBI-10176618"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"P27658","geneName":"COL8A1","intActId":"EBI-747133"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q08AM6","intActId":"EBI-2107455"},"interactantTwo":{"uniProtKBAccession":"P05813","geneName":"CRY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