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Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8C1B1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24486153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27666745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28726242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28814570"}],"value":"Interacts with CAMSAP3 (By similarity). Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP2-decorated microtubule stretches (PubMed:24486153). Interacts with a complex formed by AKAP9 and PDE4DIP isoform 13/MMG8/SMYLE, which recruits CAMSAP2 to the Golgi (PubMed:27666745, PubMed:28814570). Interacts with MAPRE1/EB1 (PubMed:28726242, PubMed:28814570)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q08AD1","intActId":"EBI-1051869"},"interactantTwo":{"uniProtKBAccession":"P29692","geneName":"EEF1D","intActId":"EBI-358607"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23169647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24486153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27666745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28814570"}],"value":"Associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:23169647, PubMed:24486153, PubMed:24706919, PubMed:24908486, PubMed:27666745, PubMed:28814570). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). The length of CAMSAP2-decorated stretches on the minus-end of microtubules depends on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches (PubMed:28814570). Recruited to the Golgi apparatus by AKAP9 and PDE4DIP isoform 13/MMG8/SMYLE (PubMed:27666745). In neurons, localizes to the minus-end of microtubules in axon and dendrites (PubMed:24908486)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23169647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24486153"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24908486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27666745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28814570"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27666745"}],"value":"Golgi apparatus","id":"SL-0132"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8C1B1"}],"value":"Cytoplasm, cytoskeleton, cilium basal 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