{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q08971","secondaryAccessions":["D6W3E5"],"uniProtkbId":"YP225_YEAST","entryAudit":{"firstPublicDate":"2006-06-27","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"1996-11-01","entryVersion":164,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein PBDC1 homolog"}}},"genes":[{"orderedLocusNames":[{"value":"YPL225W"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 37500 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PBDC1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Protein PBDC1 homolog","featureId":"PRO_0000242144"},{"type":"Beta strand","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Helix","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Helix","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Turn","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Helix","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Turn","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Helix","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Turn","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Beta strand","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Helix","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Turn","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]},{"type":"Helix","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2JYN"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"9169875","citationType":"journal article","authors":["Bussey H.","Storms R.K.","Ahmed A.","Albermann K.","Allen E.","Ansorge W.","Araujo R.","Aparicio A.","Barrell B.G.","Badcock K.","Benes V.","Botstein D.","Bowman S.","Brueckner M.","Carpenter J.","Cherry J.M.","Chung E.","Churcher C.M.","Coster F.","Davis K.","Davis R.W.","Dietrich F.S.","Delius H.","DiPaolo T.","Dubois E.","Duesterhoeft A.","Duncan M.","Floeth M.","Fortin N.","Friesen J.D.","Fritz C.","Goffeau A.","Hall J.","Hebling U.","Heumann K.","Hilbert H.","Hillier L.W.","Hunicke-Smith S.","Hyman R.W.","Johnston M.","Kalman S.","Kleine K.","Komp C.","Kurdi O.","Lashkari D.","Lew H.","Lin A.","Lin D.","Louis E.J.","Marathe R.","Messenguy F.","Mewes H.-W.","Mirtipati S.","Moestl D.","Mueller-Auer S.","Namath A.","Nentwich U.","Oefner P.","Pearson D.","Petel F.X.","Pohl T.M.","Purnelle B.","Rajandream M.A.","Rechmann S.","Rieger M.","Riles L.","Roberts D.","Schaefer M.","Scharfe M.","Scherens B.","Schramm S.","Schroeder M.","Sdicu A.-M.","Tettelin H.","Urrestarazu L.A.","Ushinsky S.","Vierendeels F.","Vissers S.","Voss H.","Walsh S.V.","Wambutt R.","Wang Y.","Wedler E.","Wedler H.","Winnett E.","Zhong W.-W.","Zollner A.","Vo D.H.","Hani J."],"citationCrossReferences":[{"database":"PubMed","id":"9169875"},{"database":"DOI","id":"10.1038/387s103"}],"title":"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.","publicationDate":"1997","journal":"Nature","firstPage":"103","lastPage":"105","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":5,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z73581","properties":[{"key":"ProteinId","value":"CAA97940.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY692562","properties":[{"key":"ProteinId","value":"AAT92581.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006949","properties":[{"key":"ProteinId","value":"DAA11211.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S65244","properties":[{"key":"EntryName","value":"S65244"}]},{"database":"PDB","id":"2JYN","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-146"}]},{"database":"PDBsum","id":"2JYN","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"35960","properties":[{"key":"Interactions","value":"120"}]},{"database":"FunCoup","id":"Q08971","properties":[{"key":"Number of interactors","value":"783"}]},{"database":"IntAct","id":"Q08971","properties":[{"key":"Interactions","value":"11"}]},{"database":"MINT","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YPL225W","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YPL225W","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"855876","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YPL225W_mRNA","properties":[{"key":"ProteinId","value":"YPL225W"},{"key":"GeneId","value":"YPL225W"}]},{"database":"KEGG","id":"sce:YPL225W","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000006146","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000006146","properties":[{"key":"GeneName","value":"YPL225W"}]},{"database":"VEuPathDB","id":"FungiDB:YPL225W","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4093","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_103791_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IQFYAFE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10248897at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-34114-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"855876","properties":[{"key":"hits","value":"0 hits in 10 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q08971","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome XVI"}]},{"database":"RNAct","id":"Q08971","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"11914276"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14562095"}]},{"database":"GO","id":"GO:0051787","properties":[{"key":"GoTerm","value":"F:misfolded protein binding"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38360885"}]},{"database":"GO","id":"GO:1990593","properties":[{"key":"GoTerm","value":"F:nascent polypeptide-associated complex binding"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38360885"}]},{"database":"GO","id":"GO:0044183","properties":[{"key":"GoTerm","value":"F:protein folding chaperone"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38360885"}]},{"database":"GO","id":"GO:0043022","properties":[{"key":"GoTerm","value":"F:ribosome binding"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38360885"}]},{"database":"GO","id":"GO:0061770","properties":[{"key":"GoTerm","value":"F:translation elongation factor binding"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38360885"}]},{"database":"GO","id":"GO:0051083","properties":[{"key":"GoTerm","value":"P:'de novo' cotranslational protein folding"},{"key":"GoEvidenceType","value":"IDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38360885"}]},{"database":"FunFam","id":"1.10.3560.10:FF:000001","properties":[{"key":"EntryName","value":"Protein PBDC1 homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.3560.10","properties":[{"key":"EntryName","value":"yst0336 like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023139","properties":[{"key":"EntryName","value":"PBDC1-like_dom_sf"}]},{"database":"InterPro","id":"IPR008476","properties":[{"key":"EntryName","value":"PBDC1_metazoa/fungi"}]},{"database":"InterPro","id":"IPR021148","properties":[{"key":"EntryName","value":"Polysacc_synth_dom"}]},{"database":"PANTHER","id":"PTHR13410","properties":[{"key":"EntryName","value":"PROTEIN PBDC1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13410:SF9","properties":[{"key":"EntryName","value":"PROTEIN PBDC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04669","properties":[{"key":"EntryName","value":"PBDC1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTFNAETADNLEDIEKQFAVVAVEQAETYWKLLTSVPGSKLRLTKFDDEIYENFMERFPEYKDVERVKKFTEEELKTKEAKERWRKFFTIFEKKIEDYNFGTLLRTDASAEYGQFTTCFVVRLQFYAFEIARNKHGLNDWIVGQK","length":146,"molWeight":17445,"crc64":"8A621FD74A720B3C","md5":"B60049137E7B764D3818465869C66AB3"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Beta strand":3,"Helix":6,"Turn":4},"uniParcId":"UPI000006A8EA"}}