{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q08462","secondaryAccessions":["B7Z2C1","Q2NKL8","Q9UDB2","Q9UPU2"],"uniProtkbId":"ADCY2_HUMAN","entryAudit":{"firstPublicDate":"1994-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-11-28","entryVersion":212,"sequenceVersion":5},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Adenylate cyclase type 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"value":"4.6.1.1"}]},"alternativeNames":[{"fullName":{"value":"ATP pyrophosphate-lyase 2"}},{"fullName":{"value":"Adenylate cyclase type II"}},{"fullName":{"value":"Adenylyl cyclase 2"}}]},"genes":[{"geneName":{"value":"ADCY2"},"synonyms":[{"value":"KIAA1060"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"value":"Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP = 3',5'-cyclic AMP + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15389"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58165"}],"ecNumber":"4.6.1.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}},{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"value":"Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro)."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"value":"Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"value":"Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11549699"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21228062"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11549699"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q08462-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q08462-2"],"sequenceIds":["VSP_055811","VSP_055812"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11549699"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8476432"}],"value":"Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"value":"The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}],"value":"Phosphorylated by RAF1"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"value":"Belongs to the adenylyl cyclase class-4/guanylyl cyclase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"Adenylate cyclase type 2","featureId":"PRO_0000195684"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":628,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":680,"modifier":"EXACT"},"end":{"value":701,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":734,"modifier":"EXACT"},"end":{"value":755,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":763,"modifier":"EXACT"},"end":{"value":780,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":801,"modifier":"EXACT"},"end":{"value":821,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":822,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":905,"modifier":"EXACT"},"end":{"value":922,"modifier":"EXACT"}},"description":"Interaction with GNAS","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}]},{"type":"Region","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":993,"modifier":"EXACT"}},"description":"Interaction with GNAS","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}]},{"type":"Binding site","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30803"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1019,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1026,"modifier":"EXACT"},"end":{"value":1030,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1066,"modifier":"EXACT"},"end":{"value":1066,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}]},{"type":"Modified residue","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":544,"modifier":"EXACT"}},"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P26769"}]},{"type":"Glycosylation","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":716,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_055811","alternativeSequence":{"originalSequence":"MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCL","alternativeSequences":["MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREES"]}},{"type":"Alternative sequence","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_055812","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in dbSNP:rs13166360","featureCrossReferences":[{"database":"dbSNP","id":"rs13166360"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_029012","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in dbSNP:rs34043481","featureCrossReferences":[{"database":"dbSNP","id":"rs34043481"}],"featureId":"VAR_048247","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"in Ref. 1; AAP97285","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"VWQILANVIIFICGNLAGAY","alternativeSequences":["GLADPGQCDHFHLWEPGXTN"]}},{"type":"Sequence conflict","location":{"start":{"value":675,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"in Ref. 6; CAA52282/AAA64923","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0115","category":"Biological process","name":"cAMP biosynthesis"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0464","category":"Ligand","name":"Manganese"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FFVHA905HVAR1","citationType":"submission","authors":["Guo J.H.","Yu L."],"title":"Molecular cloning of human adenylyl cyclase gene.","publicationDate":"AUG-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Amygdala","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.-F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANT LEU-147"]},{"referenceNumber":5,"citation":{"id":"10470851","citationType":"journal article","authors":["Kikuno R.","Nagase T.","Ishikawa K.","Hirosawa M.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10470851"},{"database":"DOI","id":"10.1093/dnares/6.3.197"}],"title":"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"1999","journal":"DNA Res.","firstPage":"197","lastPage":"205","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1091 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"1427768","citationType":"journal article","authors":["Stengel D.","Parma J.","Gannage M.-H.","Roeckel N.","Mattei M.-G.","Barouki R.","Hanoune J."],"citationCrossReferences":[{"database":"PubMed","id":"1427768"},{"database":"DOI","id":"10.1007/bf00210755"}],"title":"Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.","publicationDate":"1992","journal":"Hum. Genet.","firstPage":"126","lastPage":"130","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 616-1091 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"8476432","citationType":"journal article","authors":["Hellevuo K.","Yoshimura M.","Kao M.","Hoffman P.L.","Cooper D.M.F.","Tabakoff B."],"citationCrossReferences":[{"database":"PubMed","id":"8476432"},{"database":"DOI","id":"10.1006/bbrc.1993.1415"}],"title":"A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.","publicationDate":"1993","journal":"Biochem. Biophys. Res. Commun.","firstPage":"311","lastPage":"318","volume":"192"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 948-1017 (ISOFORM 1)","TISSUE SPECIFICITY"]},{"referenceNumber":8,"citation":{"id":"11549699","citationType":"journal article","authors":["Cote M.","Guillon G.","Payet M.D.","Gallo-Payet N."],"citationCrossReferences":[{"database":"PubMed","id":"11549699"},{"database":"DOI","id":"10.1210/jcem.86.9.7837"}],"title":"Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.","publicationDate":"2001","journal":"J. Clin. Endocrinol. Metab.","firstPage":"4495","lastPage":"4503","volume":"86"},"referencePositions":["TISSUE SPECIFICITY","SUBCELLULAR LOCATION"]},{"referenceNumber":9,"citation":{"id":"15385642","citationType":"journal article","authors":["Ding Q.","Gros R.","Gray I.D.","Taussig R.","Ferguson S.S.","Feldman R.D."],"citationCrossReferences":[{"database":"PubMed","id":"15385642"},{"database":"DOI","id":"10.1124/mol.66.4.921"}],"title":"Raf kinase activation of adenylyl cyclases: isoform-selective regulation.","publicationDate":"2004","journal":"Mol. Pharmacol.","firstPage":"921","lastPage":"928","volume":"66"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","COFACTOR","ACTIVITY REGULATION","PHOSPHORYLATION BY RAF1","SUBCELLULAR LOCATION","INTERACTION WITH RAF1"]},{"referenceNumber":10,"citation":{"id":"21228062","citationType":"journal article","authors":["Bogard A.S.","Xu C.","Ostrom R.S."],"citationCrossReferences":[{"database":"PubMed","id":"21228062"},{"database":"DOI","id":"10.1124/jpet.110.177923"}],"title":"Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.","publicationDate":"2011","journal":"J. Pharmacol. Exp. Ther.","firstPage":"209","lastPage":"217","volume":"337"},"referencePositions":["SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF410885","properties":[{"key":"ProteinId","value":"AAP97285.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK294555","properties":[{"key":"ProteinId","value":"BAH11807.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC010346","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC010437","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC024577","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC093305","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113366","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC111743","properties":[{"key":"ProteinId","value":"AAI11744.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB028983","properties":[{"key":"ProteinId","value":"BAA83012.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X74210","properties":[{"key":"ProteinId","value":"CAA52282.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L21993","properties":[{"key":"ProteinId","value":"AAA64923.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3872.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q08462-1"},{"database":"PIR","id":"I37136","properties":[{"key":"EntryName","value":"I37136"}]},{"database":"RefSeq","id":"NP_065433.2","properties":[{"key":"NucleotideSequenceId","value":"NM_020546.3"}],"isoformId":"Q08462-1"},{"database":"AlphaFoldDB","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"106622","properties":[{"key":"Interactions","value":"14"}]},{"database":"CORUM","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-422N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q08462","properties":[{"key":"Number of interactors","value":"1540"}]},{"database":"IntAct","id":"Q08462","properties":[{"key":"Interactions","value":"7"}]},{"database":"MINT","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ADCY2","properties":[{"key":"Evidences","value":"22 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000342952","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3760","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB06843","properties":[{"key":"GenericName","value":"2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE"}]},{"database":"DrugBank","id":"DB01274","properties":[{"key":"GenericName","value":"Arformoterol"}]},{"database":"DrugBank","id":"DB09121","properties":[{"key":"GenericName","value":"Aurothioglucose"}]},{"database":"DrugBank","id":"DB02587","properties":[{"key":"GenericName","value":"Colforsin"}]},{"database":"GlyCosmos","id":"Q08462","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q08462","properties":[{"key":"glycosylation","value":"3 sites"}]},{"database":"iPTMnet","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ADCY2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"118572617","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000342952","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58613","properties":[{"key":"Description","value":"-"}],"isoformId":"Q08462-1"},{"database":"ProteomicsDB","id":"6429","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"22409","properties":[{"key":"antibodies","value":"179 antibodies from 32 providers"}]},{"database":"DNASU","id":"108","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000338316.9","properties":[{"key":"ProteinId","value":"ENSP00000342952.4"},{"key":"GeneId","value":"ENSG00000078295.18"}],"isoformId":"Q08462-1"},{"database":"GeneID","id":"108","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:108","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000338316.9","properties":[{"key":"ProteinId","value":"ENSP00000342952.4"},{"key":"RefSeqNucleotideId","value":"NM_020546.3"},{"key":"RefSeqProteinId","value":"NP_065433.2"}]},{"database":"UCSC","id":"uc003jdz.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q08462-1"},{"database":"AGR","id":"HGNC:233","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA24561","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"108","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"108","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ADCY2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:233","properties":[{"key":"GeneName","value":"ADCY2"}]},{"database":"HPA","id":"ENSG00000078295","properties":[{"key":"ExpressionPatterns","value":"Group enriched (brain, skeletal muscle, tongue)"}]},{"database":"MIM","id":"103071","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000078295","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000078295","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3619","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156424","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001072_2_5_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IRILCFN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10035433at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q08462","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.6.1.1","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-163359","properties":[{"key":"PathwayName","value":"Glucagon signaling in metabolic regulation"}]},{"database":"Reactome","id":"R-HSA-163615","properties":[{"key":"PathwayName","value":"PKA activation"}]},{"database":"Reactome","id":"R-HSA-164378","properties":[{"key":"PathwayName","value":"PKA activation in glucagon signalling"}]},{"database":"Reactome","id":"R-HSA-170660","properties":[{"key":"PathwayName","value":"Adenylate cyclase activating pathway"}]},{"database":"Reactome","id":"R-HSA-170670","properties":[{"key":"PathwayName","value":"Adenylate cyclase inhibitory pathway"}]},{"database":"Reactome","id":"R-HSA-418555","properties":[{"key":"PathwayName","value":"G alpha (s) signalling events"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"Reactome","id":"R-HSA-418597","properties":[{"key":"PathwayName","value":"G alpha (z) signalling events"}]},{"database":"Reactome","id":"R-HSA-432040","properties":[{"key":"PathwayName","value":"Vasopressin regulates renal water homeostasis via Aquaporins"}]},{"database":"Reactome","id":"R-HSA-5610787","properties":[{"key":"PathwayName","value":"Hedgehog 'off' state"}]},{"database":"Reactome","id":"R-HSA-9634597","properties":[{"key":"PathwayName","value":"GPER1 signaling"}]},{"database":"Reactome","id":"R-HSA-9660821","properties":[{"key":"PathwayName","value":"ADORA2B mediated anti-inflammatory cytokines production"}]},{"database":"Reactome","id":"R-HSA-9664323","properties":[{"key":"PathwayName","value":"FCGR3A-mediated IL10 synthesis"}]},{"database":"Reactome","id":"R-HSA-9856530","properties":[{"key":"PathwayName","value":"High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells"}]},{"database":"SignaLink","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000078295","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"108","properties":[{"key":"hits","value":"3 hits in 1145 CRISPR screens"}]},{"database":"ChiTaRS","id":"ADCY2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"ADCY2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"108","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q08462","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q08462","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q08462","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000078295","properties":[{"key":"ExpressionPatterns","value":"Expressed in middle temporal gyrus and 179 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q08462","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11549699"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}]},{"database":"GO","id":"GO:0045121","properties":[{"key":"GoTerm","value":"C:membrane raft"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11549699"}]},{"database":"GO","id":"GO:0004016","properties":[{"key":"GoTerm","value":"F:adenylate cyclase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15385642"}]},{"database":"GO","id":"GO:0008179","properties":[{"key":"GoTerm","value":"F:adenylate cyclase binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030145","properties":[{"key":"GoTerm","value":"F:manganese ion binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007189","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007188","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0006171","properties":[{"key":"GoTerm","value":"P:cAMP biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1904322","properties":[{"key":"GoTerm","value":"P:cellular response to forskolin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071377","properties":[{"key":"GoTerm","value":"P:cellular response to glucagon stimulus"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003091","properties":[{"key":"GoTerm","value":"P:renal water homeostasis"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0097700","properties":[{"key":"GoTerm","value":"P:vascular endothelial cell response to laminar fluid shear stress"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"CDD","id":"cd07302","properties":[{"key":"EntryName","value":"CHD"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"3.30.70.1230:FF:000003","properties":[{"key":"EntryName","value":"Adenylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1230:FF:000010","properties":[{"key":"EntryName","value":"Adenylate cyclase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1230","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001054","properties":[{"key":"EntryName","value":"A/G_cyclase"}]},{"database":"InterPro","id":"IPR018297","properties":[{"key":"EntryName","value":"A/G_cyclase_CS"}]},{"database":"InterPro","id":"IPR032628","properties":[{"key":"EntryName","value":"AC_N"}]},{"database":"InterPro","id":"IPR030672","properties":[{"key":"EntryName","value":"Adcy"}]},{"database":"InterPro","id":"IPR009398","properties":[{"key":"EntryName","value":"Adcy_conserved_dom"}]},{"database":"InterPro","id":"IPR029787","properties":[{"key":"EntryName","value":"Nucleotide_cyclase"}]},{"database":"PANTHER","id":"PTHR45627","properties":[{"key":"EntryName","value":"ADENYLATE CYCLASE TYPE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45627:SF6","properties":[{"key":"EntryName","value":"ADENYLATE CYCLASE TYPE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16214","properties":[{"key":"EntryName","value":"AC_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06327","properties":[{"key":"EntryName","value":"Adcy_cons_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00211","properties":[{"key":"EntryName","value":"Guanylate_cyc"},{"key":"MatchStatus","value":"2"}]},{"database":"PIRSF","id":"PIRSF039050","properties":[{"key":"EntryName","value":"Ade_cyc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00044","properties":[{"key":"EntryName","value":"CYCc"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55073","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00452","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50125","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS","length":1091,"molWeight":123603,"crc64":"41FD8BC607C075D1","md5":"06F64FFEC02B407F7C7F006AB7EABC57"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":12,"Region":2,"Binding site":12,"Modified residue":2,"Glycosylation":2,"Alternative sequence":2,"Natural variant":2,"Sequence conflict":2},"uniParcId":"UPI000066D9F2"}}