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CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"value":"Has a role in fruiting body development, sporulation and aggregation"}],"commentType":"FUNCTION"},{"texts":[{"value":"Operon expression begins by 6 hours after starvation has initiated development and is under strong negative autoregulation"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17369305"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7693658"}],"value":"Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7693658"}],"value":"Essential for sporulation, decreases sporulation 100 to 1000-fold, aggregation is defective"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CRISPR-associated protein Cas7/Cst2/DevR family. Subtype I-B/Tneap subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"CRISPR-associated protein Cas7/Cst2/DevR","featureId":"PRO_0000079871"}],"keywords":[{"id":"KW-0051","category":"Biological process","name":"Antiviral defense"},{"id":"KW-0293","category":"Developmental stage","name":"Fruiting body"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0749","category":"Biological process","name":"Sporulation"}],"references":[{"referenceNumber":1,"citation":{"id":"7693658","citationType":"journal article","authors":["Thoeny-Meyer L.","Kaiser D."],"citationCrossReferences":[{"database":"PubMed","id":"7693658"},{"database":"DOI","id":"10.1128/jb.175.22.7450-7462.1993"}],"title":"devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus.","publicationDate":"1993","journal":"J. 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U.S.A.","firstPage":"15200","lastPage":"15205","volume":"103"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"DK1622","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"17369305","citationType":"journal article","authors":["Viswanathan P.","Murphy K.","Julien B.","Garza A.G.","Kroos L."],"citationCrossReferences":[{"database":"PubMed","id":"17369305"},{"database":"DOI","id":"10.1128/jb.00187-07"}],"title":"Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.","publicationDate":"2007","journal":"J. 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