ID   DERM_HUMAN              Reviewed;         201 AA.
AC   Q07507; A8K981; Q8N4R2; Q9UIX8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   13-DEC-2002, sequence version 2.
DT   27-MAR-2024, entry version 172.
DE   RecName: Full=Dermatopontin;
DE   AltName: Full=Tyrosine-rich acidic matrix protein;
DE            Short=TRAMP;
DE   Flags: Precursor;
GN   Name=DPT;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=8104875; DOI=10.1006/geno.1993.1348;
RA   Superti-Furga A., Rocchi M., Schaefer B.W., Gitzelmann R.;
RT   "Complementary DNA sequence and chromosomal mapping of a human
RT   proteoglycan-binding cell-adhesion protein (dermatopontin).";
RL   Genomics 17:463-467(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=10233760; DOI=10.1046/j.1523-1747.1999.00563.x;
RA   Kuroda K., Okamoto O., Shinkai H.;
RT   "Dermatopontin expression is decreased in hypertrophic scar and systemic
RT   sclerosis skin fibroblasts and is regulated by transforming growth factor-
RT   beta1, interleukin-4, and matrix collagen.";
RL   J. Invest. Dermatol. 112:706-710(1999).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: Seems to mediate adhesion by cell surface integrin binding.
CC       May serve as a communication link between the dermal fibroblast cell
CC       surface and its extracellular matrix environment. Enhances TGFB1
CC       activity. Inhibits cell proliferation. Accelerates collagen fibril
CC       formation, and stabilizes collagen fibrils against low-temperature
CC       dissociation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TGFB1, DCN and collagen. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q07507; PRO_0000018520 [P28300]: LOX; NbExp=2; IntAct=EBI-719535, EBI-20724846;
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in fibroblasts, heart, skeletal muscle,
CC       brain and pancreas. Expressed at an intermediate level in lung and
CC       kidney, and at a low level in liver and placenta. Expressed at a lower
CC       level in fibroblasts from hypertrophic scar lesional skin and in
CC       fibroblasts from patients with systemic sclerosis than in normal skin
CC       fibroblasts. {ECO:0000269|PubMed:10233760, ECO:0000269|PubMed:8104875}.
CC   -!- INDUCTION: Induced by TGFB1, repressed by IL4/interleukin-4.
CC       {ECO:0000269|PubMed:10233760}.
CC   -!- PTM: Sulfated on tyrosine residue(s). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dermatopontin family. {ECO:0000305}.
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DR   EMBL; Z22865; CAA80487.1; -; mRNA.
DR   EMBL; AK292596; BAF85285.1; -; mRNA.
DR   EMBL; AL049798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471067; EAW90830.1; -; Genomic_DNA.
DR   EMBL; BC033736; AAH33736.1; -; mRNA.
DR   CCDS; CCDS1275.1; -.
DR   PIR; A47220; A47220.
DR   RefSeq; NP_001928.2; NM_001937.4.
DR   AlphaFoldDB; Q07507; -.
DR   BioGRID; 108139; 2.
DR   IntAct; Q07507; 4.
DR   STRING; 9606.ENSP00000356791; -.
DR   GlyGen; Q07507; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q07507; -.
DR   PhosphoSitePlus; Q07507; -.
DR   BioMuta; DPT; -.
DR   jPOST; Q07507; -.
DR   MassIVE; Q07507; -.
DR   PaxDb; 9606-ENSP00000356791; -.
DR   PeptideAtlas; Q07507; -.
DR   ProteomicsDB; 58518; -.
DR   Antibodypedia; 34354; 193 antibodies from 30 providers.
DR   DNASU; 1805; -.
DR   Ensembl; ENST00000367817.4; ENSP00000356791.3; ENSG00000143196.5.
DR   GeneID; 1805; -.
DR   KEGG; hsa:1805; -.
DR   MANE-Select; ENST00000367817.4; ENSP00000356791.3; NM_001937.5; NP_001928.2.
DR   UCSC; uc001gfp.4; human.
DR   AGR; HGNC:3011; -.
DR   CTD; 1805; -.
DR   DisGeNET; 1805; -.
DR   GeneCards; DPT; -.
DR   HGNC; HGNC:3011; DPT.
DR   HPA; ENSG00000143196; Tissue enhanced (intestine).
DR   MIM; 125597; gene.
DR   neXtProt; NX_Q07507; -.
DR   OpenTargets; ENSG00000143196; -.
DR   PharmGKB; PA27471; -.
DR   VEuPathDB; HostDB:ENSG00000143196; -.
DR   eggNOG; ENOG502RTKC; Eukaryota.
DR   GeneTree; ENSGT00390000010760; -.
DR   HOGENOM; CLU_122082_1_0_1; -.
DR   InParanoid; Q07507; -.
DR   OMA; EIDMISY; -.
DR   OrthoDB; 3977498at2759; -.
DR   PhylomeDB; Q07507; -.
DR   TreeFam; TF328602; -.
DR   PathwayCommons; Q07507; -.
DR   SignaLink; Q07507; -.
DR   BioGRID-ORCS; 1805; 10 hits in 1143 CRISPR screens.
DR   ChiTaRS; DPT; human.
DR   GeneWiki; Dermatopontin; -.
DR   GenomeRNAi; 1805; -.
DR   Pharos; Q07507; Tbio.
DR   PRO; PR:Q07507; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q07507; Protein.
DR   Bgee; ENSG00000143196; Expressed in smooth muscle tissue and 91 other cell types or tissues.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; ISS:BHF-UCL.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030199; P:collagen fibril organization; IBA:GO_Central.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   InterPro; IPR026645; Dermatopontin.
DR   PANTHER; PTHR15040:SF2; DERMATOPONTIN; 1.
DR   PANTHER; PTHR15040; DERMATOPONTIN-RELATED; 1.
DR   Pfam; PF14704; DERM; 1.
DR   Genevisible; Q07507; HS.
PE   1: Evidence at protein level;
KW   Cell adhesion; Disulfide bond; Extracellular matrix;
KW   Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal;
KW   Sulfation.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..201
FT                   /note="Dermatopontin"
FT                   /id="PRO_0000007368"
FT   REPEAT          26..79
FT                   /note="1-1"
FT   REPEAT          70..75
FT                   /note="2-1"
FT   REPEAT          80..135
FT                   /note="1-2"
FT   REPEAT          125..130
FT                   /note="2-2"
FT   REPEAT          181..186
FT                   /note="3-3"
FT   REGION          26..186
FT                   /note="2 X 53-55 AA tandem repeats"
FT   REGION          70..186
FT                   /note="3 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P19427"
FT   MOD_RES         23
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         162
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         164
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         166
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         167
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         194
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        50..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..132
FT                   /note="Or C-90 with C-133"
FT                   /evidence="ECO:0000250"
FT   DISULFID        106..133
FT                   /note="Or C-106 with C-132"
FT                   /evidence="ECO:0000250"
FT   DISULFID        139..196
FT                   /evidence="ECO:0000250"
FT   DISULFID        143..189
FT                   /evidence="ECO:0000255"
FT   VARIANT         201
FT                   /note="V -> I (in dbSNP:rs6698023)"
FT                   /id="VAR_048888"
FT   CONFLICT        10
FT                   /note="L -> M (in Ref. 1; CAA80487)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        147
FT                   /note="T -> I (in Ref. 5; AAH33736)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   201 AA;  24005 MW;  C886D2FB624DDB49 CRC64;
     MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC PQGQVIVAVR
     SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM EWYQTCSNNG LVAGFQSRYF
     ESVLDREWQF YCCRYSKRCP YSCWLTTEYP GHYGEEMDMI SYNYDYYIRG ATTTFSAVER
     DRQWKFIMCR MTEYDCEFAN V
//