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This enzyme also displays guanylyltransferase activity to form a covalent complex, methyltransferase-m(7)GMP, from which 7-methyl-GMP is transferred to the mRNA to create the cap structure"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P33424"},{"evidenceCode":"ECO:0000305"}],"value":"Macro domain: Contains an ADP-ribose hydrolase activity that binds ADP-ribose and catalyzes the removal of mono-ADP-ribose (de-MARylation) and poly-ADP-ribose (de-PARylation), usually bound to a glutamate or aspartate residue (By similarity). De-MARylation reaction is 16-folder quicker than de-PARylation. ADP-ribose hydrolase activity allows the virus to interfere with the host immune defenses involving poly-ADP-ribose polymerases (PARPs) (Probable)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q81862"}],"value":"Y-domain: Indispensable for virus replication"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q81862"}],"value":"Putative protease: The putative protease domain although necessary for replication of the virus may not be a protease but rather a structural Zn(2+)-binding domain. 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Also participates in viral genome replication, RNA translocation and genome packaging/unpackaging (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q81862"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WC28"}],"value":"RNA-directed RNA polymerase: Plays an essential role in the virus replication (By similarity). 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The helicase activity stimulates the de-PARylation (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P33424"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q81862"}],"value":"Contains a methyltransferase domain, a Y-domain, a putative protease region, a zinc-binding region with similarity to calycins, a proline-rich disordered hypervariable region (HVR), a macro domain (also called X-domain), a helicase domain and an RNA-dependent RNA polymerase domain (By similarity). 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