{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q02754","secondaryAccessions":["D6W3U8","Q6Q586"],"uniProtkbId":"YP067_YEAST","entryAudit":{"firstPublicDate":"2006-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":144,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","commonName":"Baker's yeast","taxonId":559292,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Saccharomycetes","Saccharomycetales","Saccharomycetaceae","Saccharomyces"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein YPL067C"}}},"genes":[{"orderedLocusNames":[{"value":"YPL067C"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562095"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562106"}],"value":"Present with 1470 molecules/cell in log phase SD medium"}],"commentType":"MISCELLANEOUS"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Uncharacterized protein YPL067C","featureId":"PRO_0000238641"},{"type":"Sequence conflict","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"in Ref. 3; AAS56658","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Helix","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Beta strand","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Beta strand","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Turn","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Beta strand","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Turn","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]},{"type":"Helix","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KCI"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"9169875","citationType":"journal article","authors":["Bussey H.","Storms R.K.","Ahmed A.","Albermann K.","Allen E.","Ansorge W.","Araujo R.","Aparicio A.","Barrell B.G.","Badcock K.","Benes V.","Botstein D.","Bowman S.","Brueckner M.","Carpenter J.","Cherry J.M.","Chung E.","Churcher C.M.","Coster F.","Davis K.","Davis R.W.","Dietrich F.S.","Delius H.","DiPaolo T.","Dubois E.","Duesterhoeft A.","Duncan M.","Floeth M.","Fortin N.","Friesen J.D.","Fritz C.","Goffeau A.","Hall J.","Hebling U.","Heumann K.","Hilbert H.","Hillier L.W.","Hunicke-Smith S.","Hyman R.W.","Johnston M.","Kalman S.","Kleine K.","Komp C.","Kurdi O.","Lashkari D.","Lew H.","Lin A.","Lin D.","Louis E.J.","Marathe R.","Messenguy F.","Mewes H.-W.","Mirtipati S.","Moestl D.","Mueller-Auer S.","Namath A.","Nentwich U.","Oefner P.","Pearson D.","Petel F.X.","Pohl T.M.","Purnelle B.","Rajandream M.A.","Rechmann S.","Rieger M.","Riles L.","Roberts D.","Schaefer M.","Scharfe M.","Scherens B.","Schramm S.","Schroeder M.","Sdicu A.-M.","Tettelin H.","Urrestarazu L.A.","Ushinsky S.","Vierendeels F.","Vissers S.","Voss H.","Walsh S.V.","Wambutt R.","Wang Y.","Wedler E.","Wedler H.","Winnett E.","Zhong W.-W.","Zollner A.","Vo D.H.","Hani J."],"citationCrossReferences":[{"database":"PubMed","id":"9169875"},{"database":"DOI","id":"10.1038/387s103"}],"title":"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.","publicationDate":"1997","journal":"Nature","firstPage":"103","lastPage":"105","volume":"387"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"24374639","citationType":"journal article","authors":["Engel S.R.","Dietrich F.S.","Fisk D.G.","Binkley G.","Balakrishnan R.","Costanzo M.C.","Dwight S.S.","Hitz B.C.","Karra K.","Nash R.S.","Weng S.","Wong E.D.","Lloyd P.","Skrzypek M.S.","Miyasato S.R.","Simison M.","Cherry J.M."],"citationCrossReferences":[{"database":"PubMed","id":"24374639"},{"database":"DOI","id":"10.1534/g3.113.008995"}],"title":"The reference genome sequence of Saccharomyces cerevisiae: Then and now.","publicationDate":"2014","journal":"G3 (Bethesda)","firstPage":"389","lastPage":"398","volume":"4"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"17322287","citationType":"journal article","authors":["Hu Y.","Rolfs A.","Bhullar B.","Murthy T.V.S.","Zhu C.","Berger M.F.","Camargo A.A.","Kelley F.","McCarron S.","Jepson D.","Richardson A.","Raphael J.","Moreira D.","Taycher E.","Zuo D.","Mohr S.","Kane M.F.","Williamson J.","Simpson A.J.G.","Bulyk M.L.","Harlow E.","Marsischky G.","Kolodner R.D.","LaBaer J."],"citationCrossReferences":[{"database":"PubMed","id":"17322287"},{"database":"DOI","id":"10.1101/gr.6037607"}],"title":"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.","publicationDate":"2007","journal":"Genome Res.","firstPage":"536","lastPage":"543","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 204508 / S288c","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14562095","citationType":"journal article","authors":["Huh W.-K.","Falvo J.V.","Gerke L.C.","Carroll A.S.","Howson R.W.","Weissman J.S.","O'Shea E.K."],"citationCrossReferences":[{"database":"PubMed","id":"14562095"},{"database":"DOI","id":"10.1038/nature02026"}],"title":"Global analysis of protein localization in budding yeast.","publicationDate":"2003","journal":"Nature","firstPage":"686","lastPage":"691","volume":"425"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":5,"citation":{"id":"14562106","citationType":"journal article","authors":["Ghaemmaghami S.","Huh W.-K.","Bower K.","Howson R.W.","Belle A.","Dephoure N.","O'Shea E.K.","Weissman J.S."],"citationCrossReferences":[{"database":"PubMed","id":"14562106"},{"database":"DOI","id":"10.1038/nature02046"}],"title":"Global analysis of protein expression in yeast.","publicationDate":"2003","journal":"Nature","firstPage":"737","lastPage":"741","volume":"425"},"referencePositions":["LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U39205","properties":[{"key":"ProteinId","value":"AAB68298.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY558332","properties":[{"key":"ProteinId","value":"AAS56658.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK006949","properties":[{"key":"ProteinId","value":"DAA11364.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S60923","properties":[{"key":"EntryName","value":"S60923"}]},{"database":"PDB","id":"5KCI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A=1-198"}]},{"database":"PDBsum","id":"5KCI","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q02754","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q02754","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"36112","properties":[{"key":"Interactions","value":"39"}]},{"database":"DIP","id":"DIP-2833N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q02754","properties":[{"key":"Number of interactors","value":"2"}]},{"database":"IntAct","id":"Q02754","properties":[{"key":"Interactions","value":"2"}]},{"database":"MINT","id":"Q02754","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"4932.YPL067C","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q02754","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"4932-YPL067C","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q02754","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"YPL067C_mRNA","properties":[{"key":"ProteinId","value":"YPL067C"},{"key":"GeneId","value":"YPL067C"}]},{"database":"KEGG","id":"sce:YPL067C","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"SGD:S000005988","properties":[{"key":"Description","value":"-"}]},{"database":"SGD","id":"S000005988","properties":[{"key":"GeneName","value":"YPL067C"}]},{"database":"VEuPathDB","id":"FungiDB:YPL067C","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S263","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_075862_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q02754","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YHDWEDL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10053431at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"YEAST:G3O-33976-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"856038","properties":[{"key":"hits","value":"0 hits in 10 CRISPR screens"}]},{"database":"PRO","id":"PR:Q02754","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002311","properties":[{"key":"Component","value":"Chromosome XVI"}]},{"database":"RNAct","id":"Q02754","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"HDA:SGD"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"14562095"}]},{"database":"GO","id":"GO:0006044","properties":[{"key":"GoTerm","value":"P:N-acetylglucosamine metabolic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR022036","properties":[{"key":"EntryName","value":"DUF3605"}]},{"database":"PANTHER","id":"PTHR35020","properties":[{"key":"EntryName","value":"N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35020:SF2","properties":[{"key":"EntryName","value":"N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12239","properties":[{"key":"EntryName","value":"DUF3605"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQQDIVNDHQEEAQGWKWEQIKEIIESGELARLKRSRQMTDKYHEHKKRTAGLDMNQYVLQKLGWSLDEPQLENAAAKAFSSSTLYAVRANDFPYNFEPGVVHLVLWSKVALPVHSPDKAVREAARARMNAFLQAQPLLRPLLSSGHVAWFVNYPELQSVARIFHAHVLLFFPRERYSAEQVKTTVDDILSHGFEPLA","length":198,"molWeight":22776,"crc64":"A2488ADC3EAEE723","md5":"B3A4DA4705D8566C653B9D3B5D8FD54E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1},"countByFeatureType":{"Chain":1,"Sequence conflict":1,"Helix":10,"Beta strand":4,"Turn":2},"uniParcId":"UPI000006B000"}}