{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q02643","secondaryAccessions":["Q99863"],"uniProtkbId":"GHRHR_HUMAN","entryAudit":{"firstPublicDate":"1993-10-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1998-07-15","entryVersion":210,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Growth hormone-releasing hormone receptor"},"shortNames":[{"value":"GHRH receptor"}]},"alternativeNames":[{"fullName":{"value":"Growth hormone-releasing factor receptor"},"shortNames":[{"value":"GRF receptor"},{"value":"GRFR"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"GHRHR"}}],"comments":[{"texts":[{"value":"Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02643","intActId":"EBI-66925167"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"value":"Pituitary gland"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Growth hormone deficiency, isolated, 4","diseaseAccession":"DI-05358","acronym":"IGHD4","description":"An autosomal recessive deficiency of growth hormone leading to early and severe growth failure and short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.","diseaseCrossReference":{"database":"MIM","id":"618157"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10084571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11232012"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12534354"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9467553"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the G protein-coupled receptor 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"Growth hormone-releasing hormone receptor","featureId":"PRO_0000012828"},{"type":"Topological domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}]},{"type":"Disulfide bond","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}]},{"type":"Disulfide bond","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}]},{"type":"Natural variant","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"in a colorectal cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036223","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"in dbSNP:rs4988496","featureCrossReferences":[{"database":"dbSNP","id":"rs4988496"}],"featureId":"VAR_033962","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"in IGHD4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8528260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9467553"}],"featureId":"VAR_081172","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"in dbSNP:rs4988498","featureCrossReferences":[{"database":"dbSNP","id":"rs4988498"}],"featureId":"VAR_033963","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in IGHD4; dbSNP:rs121918118","featureCrossReferences":[{"database":"dbSNP","id":"rs121918118"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11232012"}],"featureId":"VAR_015796","alternativeSequence":{"originalSequence":"L","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in IGHD4; reduced cAMP response to GHRH; dbSNP:rs774281185","featureCrossReferences":[{"database":"dbSNP","id":"rs774281185"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12534354"}],"featureId":"VAR_015797","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"in IGHD4; dbSNP:rs121918120","featureCrossReferences":[{"database":"dbSNP","id":"rs121918120"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11232012"}],"featureId":"VAR_015798","alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in dbSNP:rs28371560","featureCrossReferences":[{"database":"dbSNP","id":"rs28371560"}],"featureId":"VAR_033964","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in IGHD4; dbSNP:rs121918119","featureCrossReferences":[{"database":"dbSNP","id":"rs121918119"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11232012"}],"featureId":"VAR_015799","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"in IGHD4; dbSNP:rs121918121","featureCrossReferences":[{"database":"dbSNP","id":"rs121918121"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10084571"}],"featureId":"VAR_015800","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"in dbSNP:rs2228078","featureCrossReferences":[{"database":"dbSNP","id":"rs2228078"}],"featureId":"VAR_033965","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in Ref. 1; AAA35890","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XDG"}]},{"type":"Beta strand","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XDG"}]},{"type":"Beta strand","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XDG"}]},{"type":"Helix","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XDG"}]},{"type":"Beta strand","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XDG"}]},{"type":"Helix","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XDG"}]},{"type":"Helix","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2XDG"}]},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Beta strand","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Beta strand","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Beta strand","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]},{"type":"Helix","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CZ5"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0242","category":"Disease","name":"Dwarfism"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1333056","citationType":"journal article","authors":["Mayo K.E."],"citationCrossReferences":[{"database":"PubMed","id":"1333056"},{"database":"DOI","id":"10.1210/mend.6.10.1333056"}],"title":"Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.","publicationDate":"1992","journal":"Mol. Endocrinol.","firstPage":"1734","lastPage":"1744","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"7680413","citationType":"journal article","authors":["Gaylinn B.D.","Harrison J.K.","Zysk J.R.","Lyons C.E. Jr.","Lynch K.R.","Thorner M.O."],"citationCrossReferences":[{"database":"PubMed","id":"7680413"},{"database":"DOI","id":"10.1210/mend.7.1.7680413"}],"title":"Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.","publicationDate":"1993","journal":"Mol. Endocrinol.","firstPage":"77","lastPage":"84","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-BG5VJBS1LMLCE","citationType":"submission","authors":["Suwa M.","Sato T.","Okouchi I.","Arita M.","Futami K.","Matsumoto S.","Tsutsumi S.","Aburatani H.","Asai K.","Akiyama Y."],"title":"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes.","publicationDate":"JUL-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-FVDH6BIFKAHTD","citationType":"submission","authors":["King M.M.","Aronstam R.S.","Sharma S.V."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"FEB-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"12853948","citationType":"journal article","authors":["Hillier L.W.","Fulton R.S.","Fulton L.A.","Graves T.A.","Pepin K.H.","Wagner-McPherson C.","Layman D.","Maas J.","Jaeger S.","Walker R.","Wylie K.","Sekhon M.","Becker M.C.","O'Laughlin M.D.","Schaller M.E.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Cordes M.","Du H.","Sun H.","Edwards J.","Bradshaw-Cordum H.","Ali J.","Andrews S.","Isak A.","Vanbrunt A.","Nguyen C.","Du F.","Lamar B.","Courtney L.","Kalicki J.","Ozersky P.","Bielicki L.","Scott K.","Holmes A.","Harkins R.","Harris A.","Strong C.M.","Hou S.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Leonard S.","Rohlfing T.","Rock S.M.","Tin-Wollam A.-M.","Abbott A.","Minx P.","Maupin R.","Strowmatt C.","Latreille P.","Miller N.","Johnson D.","Murray J.","Woessner J.P.","Wendl M.C.","Yang S.-P.","Schultz B.R.","Wallis J.W.","Spieth J.","Bieri T.A.","Nelson J.O.","Berkowicz N.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Bedell J.A.","Mardis E.R.","Clifton S.W.","Chissoe S.L.","Marra M.A.","Raymond C.","Haugen E.","Gillett W.","Zhou Y.","James R.","Phelps K.","Iadanoto S.","Bubb K.","Simms E.","Levy R.","Clendenning J.","Kaul R.","Kent W.J.","Furey T.S.","Baertsch R.A.","Brent M.R.","Keibler E.","Flicek P.","Bork P.","Suyama M.","Bailey J.A.","Portnoy M.E.","Torrents D.","Chinwalla A.T.","Gish W.R.","Eddy S.R.","McPherson J.D.","Olson M.V.","Eichler E.E.","Green E.D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"12853948"},{"database":"DOI","id":"10.1038/nature01782"}],"title":"The DNA sequence of human chromosome 7.","publicationDate":"2003","journal":"Nature","firstPage":"157","lastPage":"164","volume":"424"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-6NMTNGNV1SVCS","citationType":"submission","authors":["Tang J.","Collu R."],"title":"The structure of the gene coding for human growth hormone releasing hormone.","publicationDate":"DEC-1996","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-271"]},{"referenceNumber":7,"citation":{"id":"8528260","citationType":"journal article","authors":["Wajnrajch M.P.","Gertner J.M.","Harbison M.D.","Chua S.C. Jr.","Leibel R.L."],"citationCrossReferences":[{"database":"PubMed","id":"8528260"},{"database":"DOI","id":"10.1038/ng0196-88"}],"title":"Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.","publicationDate":"1996","journal":"Nat. Genet.","firstPage":"88","lastPage":"90","volume":"12"},"referencePositions":["INVOLVEMENT IN IGHD4","VARIANT IGHD4 72-GLU--CYS-423 DEL"]},{"referenceNumber":8,"citation":{"id":"9467553","citationType":"journal article","authors":["Netchine I.","Talon P.","Dastot F.","Vitaux F.","Goossens M.","Amselem S."],"citationCrossReferences":[{"database":"PubMed","id":"9467553"},{"database":"DOI","id":"10.1210/jcem.83.2.4528"}],"title":"Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.","publicationDate":"1998","journal":"J. Clin. Endocrinol. Metab.","firstPage":"432","lastPage":"436","volume":"83"},"referencePositions":["INVOLVEMENT IN IGHD4","VARIANT IGHD4 72-GLU--CYS-423 DEL"]},{"referenceNumber":9,"citation":{"id":"CI-C8U8TK7TU3ESK","citationType":"submission","authoringGroup":["Structural genomics consortium (SGC)"],"title":"Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.","publicationDate":"JUN-2010","submissionDatabase":"PDB data bank"},"referencePositions":["X-RAY CRYSTALLOGRAPHY","DISULFIDE BONDS"]},{"referenceNumber":10,"citation":{"id":"11232012","citationType":"journal article","authors":["Salvatori R.","Fan X.","Phillips J.A. III","Espigares-Martin R.","Martin De Lara I.","Freeman K.L.","Plotnick L.","Al-Ashwal A.","Levine M.A."],"citationCrossReferences":[{"database":"PubMed","id":"11232012"},{"database":"DOI","id":"10.1210/jcem.86.1.7156"}],"title":"Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB.","publicationDate":"2001","journal":"J. Clin. Endocrinol. Metab.","firstPage":"273","lastPage":"279","volume":"86"},"referencePositions":["VARIANTS IGHD4 HIS-144; GLU-222 AND CYS-242"]},{"referenceNumber":11,"citation":{"id":"10084571","citationType":"journal article","authors":["Salvatori R.","Hayashida C.Y.","Aguiar-Oliveira M.H.","Phillips J.A. III","Souza A.H.","Gondo R.G.","Toledo S.P.","Conceicao M.M.","Prince M.","Maheshwari H.G.","Baumann G.","Levine M.A."],"citationCrossReferences":[{"database":"PubMed","id":"10084571"},{"database":"DOI","id":"10.1210/jcem.84.3.5599"}],"title":"Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.","publicationDate":"1999","journal":"J. Clin. Endocrinol. Metab.","firstPage":"917","lastPage":"923","volume":"84"},"referencePositions":["VARIANT IGHD4 GLU-329"]},{"referenceNumber":12,"citation":{"id":"12534354","citationType":"journal article","authors":["Carakushansky M.","Whatmore A.J.","Clayton P.E.","Shalet S.M.","Gleeson H.K.","Price D.A.","Levine M.A.","Salvatori R."],"citationCrossReferences":[{"database":"PubMed","id":"12534354"},{"database":"DOI","id":"10.1530/eje.0.1480025"}],"title":"A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency.","publicationDate":"2003","journal":"Eur. J. Endocrinol.","firstPage":"25","lastPage":"30","volume":"148"},"referencePositions":["VARIANT IGHD4 VAL-176"]},{"referenceNumber":13,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] THR-45"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L01406","properties":[{"key":"ProteinId","value":"AAA35890.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L09237","properties":[{"key":"ProteinId","value":"AAA58619.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB065701","properties":[{"key":"ProteinId","value":"BAC05924.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY557192","properties":[{"key":"ProteinId","value":"AAS59864.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC005155","properties":[{"key":"ProteinId","value":"AAC23789.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U42225","properties":[{"key":"ProteinId","value":"AAB37758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U42222","properties":[{"key":"ProteinId","value":"AAB37758.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U42223","properties":[{"key":"ProteinId","value":"AAB37758.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U42224","properties":[{"key":"ProteinId","value":"AAB37758.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS5432.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A45363","properties":[{"key":"EntryName","value":"A45363"}]},{"database":"RefSeq","id":"NP_000814.2","properties":[{"key":"NucleotideSequenceId","value":"NM_000823.4"}]},{"database":"PDB","id":"24TB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"R=23-405"}]},{"database":"PDB","id":"24TI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.88 A"},{"key":"Chains","value":"R=23-405"}]},{"database":"PDB","id":"2XDG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A/B=34-123"}]},{"database":"PDB","id":"7CZ5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"R=23-405"}]},{"database":"AlphaFoldDB","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30505","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108959","properties":[{"key":"Interactions","value":"2"}]},{"database":"CORUM","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q02643","properties":[{"key":"Number of interactors","value":"426"}]},{"database":"IntAct","id":"Q02643","properties":[{"key":"Interactions","value":"75"}]},{"database":"NDEx","id":"IQUERY-CP-GHRHR","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000320180","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2032","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB19510","properties":[{"key":"GenericName","value":"Examorelin"}]},{"database":"DrugBank","id":"DB00010","properties":[{"key":"GenericName","value":"Sermorelin"}]},{"database":"DrugBank","id":"DB08869","properties":[{"key":"GenericName","value":"Tesamorelin"}]},{"database":"DrugCentral","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"247","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.A.14.4.7","properties":[{"key":"FamilyName","value":"the g-protein-coupled receptor (gpcr) family"}]},{"database":"GlyCosmos","id":"Q02643","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"Q02643","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"PhosphoSitePlus","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GHRHR","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"3041685","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000320180","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3360","properties":[{"key":"antibodies","value":"344 antibodies from 34 providers"}]},{"database":"DNASU","id":"2692","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000326139.7","properties":[{"key":"ProteinId","value":"ENSP00000320180.2"},{"key":"GeneId","value":"ENSG00000106128.20"}]},{"database":"GeneID","id":"2692","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2692","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000326139.7","properties":[{"key":"ProteinId","value":"ENSP00000320180.2"},{"key":"RefSeqNucleotideId","value":"NM_000823.4"},{"key":"RefSeqProteinId","value":"NP_000814.2"}]},{"database":"UCSC","id":"uc003tbx.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:4266","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA28676","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2692","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2692","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GHRHR","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4266","properties":[{"key":"GeneName","value":"GHRHR"}]},{"database":"HPA","id":"ENSG00000106128","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (pituitary)"}]},{"database":"MalaCards","id":"GHRHR","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"139191","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618157","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000106128","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"684247","properties":[{"key":"Disease","value":"Isolated growth hormone deficiency type IV"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000106128","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4564","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000159858","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAEWMPN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5967113at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q02643","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-418555","properties":[{"key":"PathwayName","value":"G alpha (s) signalling events"}]},{"database":"Reactome","id":"R-HSA-420092","properties":[{"key":"PathwayName","value":"Glucagon-type ligand receptors"}]},{"database":"SignaLink","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000106128","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2692","properties":[{"key":"hits","value":"7 hits in 1154 CRISPR screens"}]},{"database":"ChiTaRS","id":"GHRHR","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Growth-hormone-releasing_hormone_receptor","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Growth_hormone-releasing_hormone_receptor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2692","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q02643","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:Q02643","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q02643","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000106128","properties":[{"key":"ExpressionPatterns","value":"Expressed in pituitary gland and 115 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q02643","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1333056"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10461027"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1333056"}]},{"database":"GO","id":"GO:0005637","properties":[{"key":"GoTerm","value":"C:nuclear inner membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10461027"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10461027"}]},{"database":"GO","id":"GO:0005640","properties":[{"key":"GoTerm","value":"C:nuclear outer membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10461027"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10461027"}]},{"database":"GO","id":"GO:0042383","properties":[{"key":"GoTerm","value":"C:sarcolemma"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030141","properties":[{"key":"GoTerm","value":"C:secretory granule"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10461027"}]},{"database":"GO","id":"GO:0008528","properties":[{"key":"GoTerm","value":"F:G protein-coupled peptide receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0004930","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor activity"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"7680413"}]},{"database":"GO","id":"GO:0019838","properties":[{"key":"GoTerm","value":"F:growth factor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7680413"}]},{"database":"GO","id":"GO:0016520","properties":[{"key":"GoTerm","value":"F:growth hormone-releasing hormone receptor activity"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"7680413"}]},{"database":"GO","id":"GO:0017046","properties":[{"key":"GoTerm","value":"F:peptide hormone binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"7680413"}]},{"database":"GO","id":"GO:0007189","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1333056"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7680413"}]},{"database":"GO","id":"GO:0141156","properties":[{"key":"GoTerm","value":"P:cAMP/PKA signal transduction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071333","properties":[{"key":"GoTerm","value":"P:cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12867592"}]},{"database":"GO","id":"GO:0046010","properties":[{"key":"GoTerm","value":"P:positive regulation of circadian sleep/wake cycle, non-REM sleep"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0060124","properties":[{"key":"GoTerm","value":"P:positive regulation of growth hormone secretion"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11773624"}]},{"database":"GO","id":"GO:0043568","properties":[{"key":"GoTerm","value":"P:positive regulation of insulin-like growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11773624"}]},{"database":"GO","id":"GO:0040018","properties":[{"key":"GoTerm","value":"P:positive regulation of multicellular organism growth"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8528260"}]},{"database":"GO","id":"GO:0043627","properties":[{"key":"GoTerm","value":"P:response to estrogen"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9482665"}]},{"database":"GO","id":"GO:0051384","properties":[{"key":"GoTerm","value":"P:response to glucocorticoid"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9482665"}]},{"database":"GO","id":"GO:0032868","properties":[{"key":"GoTerm","value":"P:response to insulin"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17356054"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000114","properties":[{"key":"EntryName","value":"Growth hormone releasing hormone receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.1240.10:FF:000014","properties":[{"key":"EntryName","value":"Growth hormone-releasing hormone receptor 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.1240.10","properties":[{"key":"EntryName","value":"GPCR, family 2, extracellular hormone receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050332","properties":[{"key":"EntryName","value":"GPCR_2"}]},{"database":"InterPro","id":"IPR017981","properties":[{"key":"EntryName","value":"GPCR_2-like_7TM"}]},{"database":"InterPro","id":"IPR036445","properties":[{"key":"EntryName","value":"GPCR_2_extracell_dom_sf"}]},{"database":"InterPro","id":"IPR001879","properties":[{"key":"EntryName","value":"GPCR_2_extracellular_dom"}]},{"database":"InterPro","id":"IPR003288","properties":[{"key":"EntryName","value":"GPCR_2_GHRH_rcpt"}]},{"database":"InterPro","id":"IPR000832","properties":[{"key":"EntryName","value":"GPCR_2_secretin-like"}]},{"database":"InterPro","id":"IPR017983","properties":[{"key":"EntryName","value":"GPCR_2_secretin-like_CS"}]},{"database":"PANTHER","id":"PTHR45620:SF14","properties":[{"key":"EntryName","value":"GROWTH HORMONE-RELEASING HORMONE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45620","properties":[{"key":"EntryName","value":"PDF RECEPTOR-LIKE PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00002","properties":[{"key":"EntryName","value":"7tm_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02793","properties":[{"key":"EntryName","value":"HRM"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01352","properties":[{"key":"EntryName","value":"GHRHRECEPTOR"}]},{"database":"PRINTS","id":"PR00249","properties":[{"key":"EntryName","value":"GPCRSECRETIN"}]},{"database":"SMART","id":"SM00008","properties":[{"key":"EntryName","value":"HormR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF111418","properties":[{"key":"EntryName","value":"Hormone receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00649","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00650","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F2_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50227","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50261","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F2_4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLAEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC","length":423,"molWeight":47402,"crc64":"C9C5E2E7D6649E06","md5":"2B44A7168D3A867E8F63B6E55F2987DB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":21,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":8,"Transmembrane":7,"Glycosylation":1,"Disulfide bond":3,"Natural variant":11,"Sequence conflict":1,"Helix":19,"Beta strand":7},"uniParcId":"UPI0000061EE1"}}