{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q02548","secondaryAccessions":["A3QVP6","A3QVP7","A3QVP8","C0KTF6","C0KTF7","C0KTF8","C0KTF9","C0KTG0","O75933","Q5SFM2","Q6S728","Q6S729","Q6S730","Q6S731","Q6S732"],"uniProtkbId":"PAX5_HUMAN","entryAudit":{"firstPublicDate":"1993-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1993-10-01","entryVersion":218,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Paired box protein Pax-5"}},"alternativeNames":[{"fullName":{"value":"B-cell-specific transcription factor"},"shortNames":[{"value":"BSAP"}]}]},"genes":[{"geneName":{"value":"PAX5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10811620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27181361"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32612238"}],"value":"Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23678172"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31941781"}],"value":"(Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q02650"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10197586"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10811620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11779502"}],"value":"Interacts with ETS1; this interaction alters PAX5 DNA-binding properties (PubMed:11779502). Binds DNA as a monomer (PubMed:11779502). Interacts with TBP; this interaction allows PAX5 to interact with the basal transcription machinery (PubMed:10197586). Interacts with RB1 (PubMed:10197586). Interacts with TLE4 (PubMed:10811620). Interacts with DAXX (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23678172"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31941781"}],"value":"(Microbial infection) Interacts (via N-terminus) with Epstein-Barr virus protein BZLF1 (via C-terminus); this interaction inhibits BZLF1-mediated lytic viral reactivation (PubMed:23678172). Interacts also with EBNA1; this interaction promotes EBNA1-dependent transcription 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The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. 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