{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q01826","secondaryAccessions":["B3KXF1","C9JTR6","Q59EQ0"],"uniProtkbId":"SATB1_HUMAN","entryAudit":{"firstPublicDate":"1993-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1993-10-01","entryVersion":226,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"DNA-binding protein SATB1"}},"alternativeNames":[{"fullName":{"value":"Special AT-rich sequence-binding protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:10541"}],"value":"SATB1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q60611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10595394"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11463840"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12374985"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12692553"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1505028"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15618465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15713622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16377216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17173041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17376900"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18337816"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19103759"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19247486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332023"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19430959"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9111059"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9548713"}],"value":"Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain as HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10595394"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11463840"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12036295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14605447"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15713622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16079286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17173041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17512569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17652321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18187506"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19103759"}],"value":"Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabilizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML and HDAC1 via the CMP domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15713622"}],"value":"(Microbial infection) Interacts (via the CMP domain) with HIV-1 Tat"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q01826","intActId":"EBI-743747"},"interactantTwo":{"uniProtKBAccession":"P55212","geneName":"CASP6","intActId":"EBI-718729"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01826","intActId":"EBI-743747"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01826","intActId":"EBI-743747"},"interactantTwo":{"uniProtKBAccession":"Q13627","geneName":"DYRK1A","intActId":"EBI-1053596"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01826","intActId":"EBI-743747"},"interactantTwo":{"uniProtKBAccession":"Q6FHY5","geneName":"MEOX2","intActId":"EBI-16439278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01826","intActId":"EBI-743747"},"interactantTwo":{"uniProtKBAccession":"Q9NZD8","geneName":"SPG21","intActId":"EBI-742688"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01826","intActId":"EBI-743747"},"interactantTwo":{"uniProtKBAccession":"P63165","geneName":"SUMO1","intActId":"EBI-80140"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q01826","intActId":"EBI-743747"},"interactantTwo":{"uniProtKBAccession":"G2XKQ0","geneName":"SUMO1P1","intActId":"EBI-10175576"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12692553"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"value":"Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences (PubMed:12692553). When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:18408014)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10800076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"value":"Nucleus matrix","id":"SL-0181"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"value":"Nucleus, PML body","id":"SL-0465"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q01826-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q01826-2"],"sequenceIds":["VSP_038296"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1505028"}],"value":"Expressed predominantly in thymus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15561718"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"value":"Sumoylated. Sumoylation promotes cleavage by caspases"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630892"}],"value":"Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15561718"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"value":"Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms cannot dimerize and lose transcription regulation function because of impaired DNA and chromatin association"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Den Hoed-de Boer-Voisin syndrome","diseaseAccession":"DI-06058","acronym":"DHDBV","description":"A disorder characterized by global developmental delay, moderately to severely impaired intellectual development, poor or absent speech, delayed motor skills, and early-onset epilepsy in many patients. Most affected individuals have feeding difficulties, poor overall growth, dysmorphic facial features, and significant dental anomalies resembling amelogenesis imperfecta. More variable features include visual defects, behavioral abnormalities, and non-specific involvement of other organ systems. DHDBV transmission pattern is consistent with autosomal dominant inheritance with incomplete penetrance and variable expressivity.","diseaseCrossReference":{"database":"MIM","id":"619229"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Developmental delay with dysmorphic facies and dental anomalies","diseaseAccession":"DI-06057","acronym":"DEFDA","description":"A disorder characterized by mild global developmental delay, impaired intellectual development, walking by 2 to 3 years, and slow language acquisition. The severity of the disorder ranges from moderate cognitive deficits to mild learning difficulties or behavioral abnormalities. Most patients have dysmorphic facial features, abnormal dentition and non-specific visual defects. DEFDA transmission pattern is consistent with autosomal dominant inheritance with incomplete penetrance and variable expressivity.","diseaseCrossReference":{"database":"MIM","id":"619228"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CUT homeobox family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAD92998.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44225/SATB1","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"DNA-binding protein SATB1","featureId":"PRO_0000202398"},{"type":"Domain","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"CMP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01326"}]},{"type":"Domain","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"CUTL","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01327"}]},{"type":"DNA binding","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"CUT 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00374"}]},{"type":"DNA binding","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"CUT 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00374"}]},{"type":"DNA binding","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":704,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Nuclear matrix targeting sequence (NMTS)"},{"type":"Region","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":649,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15970696"}]},{"type":"Motif","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Protein interaction"},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":591,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16991"}],"ligand":{"name":"DNA","id":"ChEBI:CHEBI:16991"},"ligandPart":{"name":"matrix attachment region (MAR) of DNA"}},{"type":"Binding site","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16991"}],"ligand":{"name":"DNA","id":"ChEBI:CHEBI:16991"},"ligandPart":{"name":"matrix attachment region (MAR) of DNA"}},{"type":"Binding site","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16991"}],"ligand":{"name":"DNA","id":"ChEBI:CHEBI:16991"},"ligandPart":{"name":"matrix attachment region (MAR) of DNA"}},{"type":"Site","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Cleavage; by caspases"},{"type":"Modified residue","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630892"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630892"}]},{"type":"Modified residue","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":637,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q60611"}]},{"type":"Cross-link","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}]},{"type":"Alternative sequence","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":592,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_038296","alternativeSequence":{"originalSequence":"I","alternativeSequences":["IQSPSPTTLGKGESRGVFLPGLPTPAPWLGAAP"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in DHDBV; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085437","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in DHDBV","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085438","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"no effect on DNA-binding or transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085439","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"in DHDBV","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085440","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"in DHDBV; stabilized DNA-binding and increased transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085441","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"in DHDBV","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085442","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"in DEFDA; reduced transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085443","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"in DHDBV","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085444","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"in DHDBV; stabilized DNA-binding and increased transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085445","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"no effect on DNA-binding or transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085446","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"in DHDBV","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085447","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"in DHDBV","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085448","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"in DHDBV; stabilized DNA-binding and increased transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085449","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"in DHDBV; stabilized DNA-binding and increased transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085450","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"in DHDBV; stabilized DNA-binding and increased transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085451","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"no effect on DNA-binding or transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085452","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":577,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"in DHDBV","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085453","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"in DHDBV; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085454","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":682,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"in DHDBV; uncertain significance; no effect on DNA-binding or transcriptional repression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085455","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":694,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"in DEFDA; altered subcellular localization forming nuclear puncta; reduced transcriptional repression of some target genes","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33513338"}],"featureId":"VAR_085456","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Loss of nuclear localization, cytoplasmic.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15970696"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Loss of nuclear localization, cytoplasmic.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15970696"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Normal nuclear localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15970696"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Normal nuclear localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15970696"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"No acetylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19103759"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A","Q","R"]}},{"type":"Mutagenesis","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"No phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630892"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"CASP6-resistant.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11463840"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Slightly reduced MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Reduced MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"Impaired MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"Reduced MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Impaired MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17652321"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Impaired MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17652321"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"Impaired MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Impaired MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Normal sumoylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"Impaired MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"Reduced MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"Reduced MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Slightly reduced MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"Reduced MAR-DNA-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16371359"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"Normal sumoylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"Reduced interaction with matrix attachment region (MAR) DNA; when associated with A-648.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9111059"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"Reduced interaction with matrix attachment region (MAR) DNA; when associated with A-646.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9111059"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":695,"modifier":"EXACT"}},"description":"Reduced interaction with matrix attachment region (MAR) DNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9111059"}],"alternativeSequence":{"originalSequence":"FQN","alternativeSequences":["AAA"]}},{"type":"Mutagenesis","location":{"start":{"value":720,"modifier":"EXACT"},"end":{"value":720,"modifier":"EXACT"}},"description":"Normal sumoylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"Loss of sumoylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Beta strand","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Beta strand","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Helix","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Helix","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Helix","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Beta strand","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Helix","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Helix","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Turn","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Beta strand","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3TUO"}]},{"type":"Helix","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3NZL"}]},{"type":"Helix","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3NZL"}]},{"type":"Turn","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3NZL"}]},{"type":"Helix","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3NZL"}]},{"type":"Beta strand","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3NZL"}]},{"type":"Helix","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3NZL"}]},{"type":"Helix","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3NZL"}]},{"type":"Helix","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2O4A"}]},{"type":"Helix","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2O4A"}]},{"type":"Helix","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2O4A"}]},{"type":"Helix","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2O49"}]},{"type":"Helix","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2O4A"}]},{"type":"Helix","location":{"start":{"value":437,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2O4A"}]},{"type":"Helix","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2MW8"}]},{"type":"Helix","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2MW8"}]},{"type":"Helix","location":{"start":{"value":687,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2MW8"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0371","category":"Domain","name":"Homeobox"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"1505028","citationType":"journal article","authors":["Dickinson L.A.","Joh T.","Kohwi Y.","Kohwi-Shigematsu T."],"citationCrossReferences":[{"database":"PubMed","id":"1505028"},{"database":"DOI","id":"10.1016/0092-8674(92)90432-c"}],"title":"A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition.","publicationDate":"1992","journal":"Cell","firstPage":"631","lastPage":"645","volume":"70"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-7K17UJ5V4NNG4","citationType":"submission","authors":["Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S.","Ohara O.","Nagase T.","Kikuno F.R."],"publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.-S.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"9111059","citationType":"journal article","authors":["Dickinson L.A.","Dickinson C.D.","Kohwi-Shigematsu T."],"citationCrossReferences":[{"database":"PubMed","id":"9111059"},{"database":"DOI","id":"10.1074/jbc.272.17.11463"}],"title":"An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"11463","lastPage":"11470","volume":"272"},"referencePositions":["FUNCTION","MUTAGENESIS OF ARG-646; ARG-648 AND 693-PHE--ASN-695"]},{"referenceNumber":8,"citation":{"id":"9548713","citationType":"journal article","authors":["de Belle I.","Cai S.","Kohwi-Shigematsu T."],"citationCrossReferences":[{"database":"PubMed","id":"9548713"},{"database":"DOI","id":"10.1083/jcb.141.2.335"}],"title":"The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops.","publicationDate":"1998","journal":"J. Cell Biol.","firstPage":"335","lastPage":"348","volume":"141"},"referencePositions":["FUNCTION"]},{"referenceNumber":9,"citation":{"id":"10595394","citationType":"journal article","authors":["Case S.S.","Huber P.","Lloyd J.A."],"citationCrossReferences":[{"database":"PubMed","id":"10595394"},{"database":"DOI","id":"10.1089/104454999314809"}],"title":"The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.","publicationDate":"1999","journal":"DNA Cell Biol.","firstPage":"805","lastPage":"817","volume":"18"},"referencePositions":["FUNCTION","IDENTIFICATION IN THE GAMMA-GLOBIN PROMOTER COMPLEX","IDENTIFICATION IN THE ENHANCER BINDING FACTOR COMPLEX"]},{"referenceNumber":10,"citation":{"id":"10800076","citationType":"journal article","authors":["Gotzmann J.","Meissner M.","Gerner C."],"citationCrossReferences":[{"database":"PubMed","id":"10800076"},{"database":"DOI","id":"10.1038/sj.cdd.4400668"}],"title":"The fate of the nuclear matrix-associated-region-binding protein SATB1 during apoptosis.","publicationDate":"2000","journal":"Cell Death Differ.","firstPage":"425","lastPage":"438","volume":"7"},"referencePositions":["CLEAVAGE BY CASPASES","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"11463840","citationType":"journal article","authors":["Galande S.","Dickinson L.A.","Mian I.S.","Sikorska M.","Kohwi-Shigematsu T."],"citationCrossReferences":[{"database":"PubMed","id":"11463840"},{"database":"DOI","id":"10.1128/mcb.21.16.5591-5604.2001"}],"title":"SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.","publicationDate":"2001","journal":"Mol. Cell. Biol.","firstPage":"5591","lastPage":"5604","volume":"21"},"referencePositions":["FUNCTION","MUTAGENESIS OF ASP-254","SUBUNIT","CLEAVAGE BY CASPASE-6"]},{"referenceNumber":12,"citation":{"id":"12036295","citationType":"journal article","authors":["Durrin L.K.","Krontiris T.G."],"citationCrossReferences":[{"database":"PubMed","id":"12036295"},{"database":"DOI","id":"10.1006/geno.2002.6772"}],"title":"The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11.","publicationDate":"2002","journal":"Genomics","firstPage":"809","lastPage":"817","volume":"79"},"referencePositions":["INTERACTION WITH POLR2J2"]},{"referenceNumber":13,"citation":{"id":"12374985","citationType":"journal article","authors":["Yasui D.","Miyano M.","Cai S.","Varga-Weisz P.","Kohwi-Shigematsu T."],"citationCrossReferences":[{"database":"PubMed","id":"12374985"},{"database":"DOI","id":"10.1038/nature01084"}],"title":"SATB1 targets chromatin remodelling to regulate genes over long distances.","publicationDate":"2002","journal":"Nature","firstPage":"641","lastPage":"645","volume":"419"},"referencePositions":["FUNCTION"]},{"referenceNumber":14,"citation":{"id":"14605447","citationType":"journal article","authors":["Fujii Y.","Kumatori A.","Nakamura M."],"citationCrossReferences":[{"database":"PubMed","id":"14605447"},{"database":"DOI","id":"10.1111/j.1348-0421.2003.tb03438.x"}],"title":"SATB1 makes a complex with p300 and represses gp91(phox) promoter activity.","publicationDate":"2003","journal":"Microbiol. Immunol.","firstPage":"803","lastPage":"811","volume":"47"},"referencePositions":["INTERACTION WITH EP300"]},{"referenceNumber":15,"citation":{"id":"12692553","citationType":"journal article","authors":["Cai S.","Han H.-J.","Kohwi-Shigematsu T."],"citationCrossReferences":[{"database":"PubMed","id":"12692553"},{"database":"DOI","id":"10.1038/ng1146"}],"title":"Tissue-specific nuclear architecture and gene expression regulated by SATB1.","publicationDate":"2003","journal":"Nat. Genet.","firstPage":"42","lastPage":"51","volume":"34"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"15618465","citationType":"journal article","authors":["Wen J.","Huang S.","Rogers H.","Dickinson L.A.","Kohwi-Shigematsu T.","Noguchi C.T."],"citationCrossReferences":[{"database":"PubMed","id":"15618465"},{"database":"DOI","id":"10.1182/blood-2004-08-2988"}],"title":"SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression.","publicationDate":"2005","journal":"Blood","firstPage":"3330","lastPage":"3339","volume":"105"},"referencePositions":["FUNCTION"]},{"referenceNumber":17,"citation":{"id":"15970696","citationType":"journal article","authors":["Nakayama Y.","Mian I.S.","Kohwi-Shigematsu T.","Ogawa T."],"citationCrossReferences":[{"database":"PubMed","id":"15970696"},{"database":"DOI","id":"10.4161/cc.4.8.1862"}],"title":"A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage.","publicationDate":"2005","journal":"Cell Cycle","firstPage":"1099","lastPage":"1106","volume":"4"},"referencePositions":["SUBCELLULAR LOCATION","MUTAGENESIS OF LYS-29; ARG-32; GLU-34 AND ASN-36","NUCLEAR LOCALIZATION SIGNAL"]},{"referenceNumber":18,"citation":{"id":"15561718","citationType":"journal article","authors":["Gocke C.B.","Yu H.","Kang J."],"citationCrossReferences":[{"database":"PubMed","id":"15561718"},{"database":"DOI","id":"10.1074/jbc.m411718200"}],"title":"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"5004","lastPage":"5012","volume":"280"},"referencePositions":["SUMOYLATION"]},{"referenceNumber":19,"citation":{"id":"15851481","citationType":"journal article","authors":["Seo J.","Lozano M.M.","Dudley J.P."],"citationCrossReferences":[{"database":"PubMed","id":"15851481"},{"database":"DOI","id":"10.1074/jbc.m414076200"}],"title":"Nuclear matrix binding regulates SATB1-mediated transcriptional repression.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"24600","lastPage":"24609","volume":"280"},"referencePositions":["SUBCELLULAR LOCATION","NUCLEAR MATRIX TARGETING SEQUENCE"]},{"referenceNumber":20,"citation":{"id":"16079286","citationType":"journal article","authors":["Yeh T.-Y.","Chuang J.-Z.","Sung C.-H."],"citationCrossReferences":[{"database":"PubMed","id":"16079286"},{"database":"DOI","id":"10.1242/jcs.02472"}],"title":"Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway.","publicationDate":"2005","journal":"J. Cell Sci.","firstPage":"3431","lastPage":"3443","volume":"118"},"referencePositions":["INTERACTION WITH DYNLT3","SUBCELLULAR LOCATION"]},{"referenceNumber":21,"citation":{"id":"15713622","citationType":"journal article","authors":["Kumar P.P.","Purbey P.K.","Ravi D.S.","Mitra D.","Galande S."],"citationCrossReferences":[{"database":"PubMed","id":"15713622"},{"database":"DOI","id":"10.1128/mcb.25.5.1620-1633.2005"}],"title":"Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells.","publicationDate":"2005","journal":"Mol. Cell. Biol.","firstPage":"1620","lastPage":"1633","volume":"25"},"referencePositions":["FUNCTION","INTERACTION WITH HIV-1 TAT (MICROBIAL INFECTION) AND HDAC1"]},{"referenceNumber":22,"citation":{"id":"16377216","citationType":"journal article","authors":["Sun Y.","Wang T.","Su Y.","Yin Y.","Xu S.","Ma C.","Han X."],"citationCrossReferences":[{"database":"PubMed","id":"16377216"},{"database":"DOI","id":"10.1016/j.cellbi.2005.10.025"}],"title":"The behavior of SATB1, a MAR-binding protein, in response to apoptosis stimulation.","publicationDate":"2006","journal":"Cell Biol. Int.","firstPage":"244","lastPage":"247","volume":"30"},"referencePositions":["FUNCTION","CLEAVAGE BY CASPASE-3"]},{"referenceNumber":23,"citation":{"id":"16630892","citationType":"journal article","authors":["Kumar P.P.","Purbey P.K.","Sinha C.K.","Notani D.","Limaye A.","Jayani R.S.","Galande S."],"citationCrossReferences":[{"database":"PubMed","id":"16630892"},{"database":"DOI","id":"10.1016/j.molcel.2006.03.010"}],"title":"Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo.","publicationDate":"2006","journal":"Mol. Cell","firstPage":"231","lastPage":"243","volume":"22"},"referencePositions":["FUNCTION","IDENTIFICATION BY MASS SPECTROMETRY","INTERACTION WITH HDAC1 AND PCAF","MUTAGENESIS OF LYS-136 AND SER-185","ACETYLATION AT LYS-136","PHOSPHORYLATION AT SER-185"]},{"referenceNumber":24,"citation":{"id":"17376900","citationType":"journal article","authors":["Kumar P.P.","Mehta S.","Purbey P.K.","Notani D.","Jayani R.S.","Purohit H.J.","Raje D.V.","Ravi D.S.","Bhonde R.R.","Mitra D.","Galande S."],"citationCrossReferences":[{"database":"PubMed","id":"17376900"},{"database":"DOI","id":"10.1128/jvi.01405-06"}],"title":"SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites.","publicationDate":"2007","journal":"J. Virol.","firstPage":"5617","lastPage":"5627","volume":"81"},"referencePositions":["FUNCTION"]},{"referenceNumber":25,"citation":{"id":"17173041","citationType":"journal article","authors":["Kumar P.P.","Bischof O.","Purbey P.K.","Notani D.","Urlaub H.","Dejean A.","Galande S."],"citationCrossReferences":[{"database":"PubMed","id":"17173041"},{"database":"DOI","id":"10.1038/ncb1516"}],"title":"Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.","publicationDate":"2007","journal":"Nat. Cell Biol.","firstPage":"45","lastPage":"56","volume":"9"},"referencePositions":["FUNCTION","INTERACTION WITH PML"]},{"referenceNumber":26,"citation":{"id":"17512569","citationType":"journal article","authors":["Lee J.","Klase Z.","Gao X.","Caldwell J.S.","Stinski M.F.","Kashanchi F.","Chao S.-H."],"citationCrossReferences":[{"database":"PubMed","id":"17512569"},{"database":"DOI","id":"10.1016/j.virol.2007.04.024"}],"title":"Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes.","publicationDate":"2007","journal":"Virology","firstPage":"117","lastPage":"125","volume":"366"},"referencePositions":["INTERACTION WITH CYTOMEGALOVIRUS UNIQUE REGION"]},{"referenceNumber":27,"citation":{"id":"18408014","citationType":"journal article","authors":["Tan J.-A.T.","Sun Y.","Song J.","Chen Y.","Krontiris T.G.","Durrin L.K."],"citationCrossReferences":[{"database":"PubMed","id":"18408014"},{"database":"DOI","id":"10.1074/jbc.m800512200"}],"title":"SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"18124","lastPage":"18134","volume":"283"},"referencePositions":["SUMOYLATION AT LYS-744","MUTAGENESIS OF LYS-411; LYS-486; LYS-720 AND LYS-744","SUBCELLULAR LOCATION","CLEAVAGE BY CASPASE-6"]},{"referenceNumber":28,"citation":{"id":"18337816","citationType":"journal article","authors":["Han H.-J.","Russo J.","Kohwi Y.","Kohwi-Shigematsu T."],"citationCrossReferences":[{"database":"PubMed","id":"18337816"},{"database":"DOI","id":"10.1038/nature06781"}],"title":"SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis.","publicationDate":"2008","journal":"Nature","firstPage":"187","lastPage":"193","volume":"452"},"referencePositions":["FUNCTION","ROLE IN BREAST TUMOR GROWTH AND METASTASIS"]},{"referenceNumber":29,"citation":{"id":"18187506","citationType":"journal article","authors":["Purbey P.K.","Singh S.","Kumar P.P.","Mehta S.","Ganesh K.N.","Mitra D.","Galande S."],"citationCrossReferences":[{"database":"PubMed","id":"18187506"},{"database":"DOI","id":"10.1093/nar/gkm1151"}],"title":"PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1.","publicationDate":"2008","journal":"Nucleic Acids Res.","firstPage":"2107","lastPage":"2122","volume":"36"},"referencePositions":["SUBUNIT","INTERACTION WITH DNA AND NUCLEAR MATRIX"]},{"referenceNumber":30,"citation":{"id":"19332023","citationType":"journal article","authors":["Gong H.","Wang Z.","Zhao G.-W.","Lv X.","Wei G.-H.","Wang L.","Liu D.-P.","Liang C.-C."],"citationCrossReferences":[{"database":"PubMed","id":"19332023"},{"database":"DOI","id":"10.1016/j.bbrc.2009.03.122"}],"title":"SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster.","publicationDate":"2009","journal":"Biochem. Biophys. Res. Commun.","firstPage":"11","lastPage":"15","volume":"383"},"referencePositions":["FUNCTION"]},{"referenceNumber":31,"citation":{"id":"19430959","citationType":"journal article","authors":["Cai R.","Xu W.","Dai B.","Cai X.","Xu R.","Lu J."],"citationCrossReferences":[{"database":"PubMed","id":"19430959"},{"database":"DOI","id":"10.1007/s11033-009-9538-y"}],"title":"SATB1 binds an intronic MAR sequence in human PI3kgamma in vitro.","publicationDate":"2010","journal":"Mol. Biol. Rep.","firstPage":"1461","lastPage":"1465","volume":"37"},"referencePositions":["FUNCTION"]},{"referenceNumber":32,"citation":{"id":"19103759","citationType":"journal article","authors":["Purbey P.K.","Singh S.","Notani D.","Kumar P.P.","Limaye A.S.","Galande S."],"citationCrossReferences":[{"database":"PubMed","id":"19103759"},{"database":"DOI","id":"10.1128/mcb.00822-08"}],"title":"Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1.","publicationDate":"2009","journal":"Mol. Cell. Biol.","firstPage":"1321","lastPage":"1337","volume":"29"},"referencePositions":["FUNCTION","MUTAGENESIS OF LYS-136","INTERACTION WITH CTBP1"]},{"referenceNumber":33,"citation":{"id":"19247486","citationType":"journal article","authors":["Wang L.","Di L.-J.","Lv X.","Zheng W.","Xue Z.","Guo Z.-C.","Liu D.-P.","Liang C.-C."],"citationCrossReferences":[{"database":"PubMed","id":"19247486"},{"database":"DOI","id":"10.1371/journal.pone.0004629"}],"title":"Inter-MAR association contributes to transcriptionally active looping events in human beta-globin gene cluster.","publicationDate":"2009","journal":"PLoS ONE","firstPage":"E4629","lastPage":"E4629","volume":"4"},"referencePositions":["FUNCTION"]},{"referenceNumber":34,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-51","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":35,"citation":{"id":"16371359","citationType":"journal article","authors":["Yamaguchi H.","Tateno M.","Yamasaki K."],"citationCrossReferences":[{"database":"PubMed","id":"16371359"},{"database":"DOI","id":"10.1074/jbc.m510933200"}],"title":"Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"5319","lastPage":"5327","volume":"281"},"referencePositions":["STRUCTURE BY NMR OF 353-490 IN COMPLEX WITH MAR DNA","MUTAGENESIS OF SER-373; ARG-380; LYS-384; ARG-395; SER-406; ARG-410; LYS-416; ARG-427; ARG-442; SER-451 AND LYS-475"]},{"referenceNumber":36,"citation":{"id":"17652321","citationType":"journal article","authors":["Yamasaki K.","Akiba T.","Yamasaki T.","Harata K."],"citationCrossReferences":[{"database":"PubMed","id":"17652321"},{"database":"DOI","id":"10.1093/nar/gkm504"}],"title":"Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1.","publicationDate":"2007","journal":"Nucleic Acids Res.","firstPage":"5073","lastPage":"5084","volume":"35"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 368-452 IN COMPLEX WITH MAR DNA","MUTAGENESIS OF GLN-402 AND GLY-403"]},{"referenceNumber":37,"citation":{"id":"33513338","citationType":"journal article","authoringGroup":["DDD Study"],"authors":["den Hoed J.","de Boer E.","Voisin N.","Dingemans A.J.M.","Guex N.","Wiel L.","Nellaker C.","Amudhavalli S.M.","Banka S.","Bena F.S.","Ben-Zeev B.","Bonagura V.R.","Bruel A.L.","Brunet T.","Brunner H.G.","Chew H.B.","Chrast J.","Cimbalistiene L.","Coon H.","Delot E.C.","Demurger F.","Denomme-Pichon A.S.","Depienne C.","Donnai D.","Dyment D.A.","Elpeleg O.","Faivre L.","Gilissen C.","Granger L.","Haber B.","Hachiya Y.","Abedi Y.H.","Hanebeck J.","Hehir-Kwa J.Y.","Horist B.","Itai T.","Jackson A.","Jewell R.","Jones K.L.","Joss S.","Kashii H.","Kato M.","Kattentidt-Mouravieva A.A.","Kok F.","Kotzaeridou U.","Krishnamurthy V.","Kucinskas V.","Kuechler A.","Lavillaureix A.","Liu P.","Manwaring L.","Matsumoto N.","Mazel B.","McWalter K.","Meiner V.","Mikati M.A.","Miyatake S.","Mizuguchi T.","Moey L.H.","Mohammed S.","Mor-Shaked H.","Mountford H.","Newbury-Ecob R.","Odent S.","Orec L.","Osmond M.","Palculict T.B.","Parker M.","Petersen A.K.","Pfundt R.","Preiksaitiene E.","Radtke K.","Ranza E.","Rosenfeld J.A.","Santiago-Sim T.","Schwager C.","Sinnema M.","Snijders Blok L.","Spillmann R.C.","Stegmann A.P.A.","Thiffault I.","Tran L.","Vaknin-Dembinsky A.","Vedovato-Dos-Santos J.H.","Schrier Vergano S.A.","Vilain E.","Vitobello A.","Wagner M.","Waheeb A.","Willing M.","Zuccarelli B.","Kini U.","Newbury D.F.","Kleefstra T.","Reymond A.","Fisher S.E.","Vissers L.E.L.M."],"citationCrossReferences":[{"database":"PubMed","id":"33513338"},{"database":"DOI","id":"10.1016/j.ajhg.2021.01.007"}],"title":"Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction.","publicationDate":"2021","journal":"Am. J. Hum. Genet.","firstPage":"346","lastPage":"356","volume":"108"},"referencePositions":["VARIANTS DHDBV LEU-181; VAL-323; ARG-402; GLN-407; GLY-407; LYS-413; ARG-420; ARG-525; GLN-530; GLY-530; LYS-530; LYS-547; ARG-577; ARG-619 AND VAL-682","CHARACTERIZATION OF VARIANTS DHDBV GLY-407; ARG-420; GLN-530; LYS-530; LYS-547 AND VAL-682","VARIANTS DEFDA 410-ARG--ASP-763 DEL AND 694-GLN--ASP-763 DEL","VARIANTS LEU-366; LEU-519 AND THR-573","CHARACTERIZATION OF VARIANTS LEU-366; LEU-519 AND THR-573","CHARACTERIZATION OF VARIANTS DEFDA 410-GLN--ASP-763 DEL AND 694-GLN--ASP-763 DEL","SUBCELLULAR LOCATION","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M97287","properties":[{"key":"ProteinId","value":"AAA60304.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK127242","properties":[{"key":"ProteinId","value":"BAG54463.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB209761","properties":[{"key":"ProteinId","value":"BAD92998.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC139618","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC144521","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471055","properties":[{"key":"ProteinId","value":"EAW64291.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001744","properties":[{"key":"ProteinId","value":"AAH01744.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2631.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01826-1"},{"database":"CCDS","id":"CCDS56242.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01826-2"},{"database":"PIR","id":"A43314","properties":[{"key":"EntryName","value":"A43314"}]},{"database":"RefSeq","id":"NP_001124482.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001131010.4"}],"isoformId":"Q01826-1"},{"database":"RefSeq","id":"NP_001182399.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001195470.3"}],"isoformId":"Q01826-2"},{"database":"RefSeq","id":"NP_001309800.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322871.2"}],"isoformId":"Q01826-2"},{"database":"RefSeq","id":"NP_001309801.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322872.2"}],"isoformId":"Q01826-1"},{"database":"RefSeq","id":"NP_001309802.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322873.2"}],"isoformId":"Q01826-1"},{"database":"RefSeq","id":"NP_001309803.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322874.2"}],"isoformId":"Q01826-1"},{"database":"RefSeq","id":"NP_001309804.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322875.2"}],"isoformId":"Q01826-1"},{"database":"RefSeq","id":"NP_002962.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002971.6"}],"isoformId":"Q01826-1"},{"database":"RefSeq","id":"XP_011532290.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011533988.4"}],"isoformId":"Q01826-2"},{"database":"RefSeq","id":"XP_011532291.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011533989.3"}],"isoformId":"Q01826-2"},{"database":"RefSeq","id":"XP_054203456.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054347481.1"}],"isoformId":"Q01826-2"},{"database":"RefSeq","id":"XP_054203457.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054347482.1"}],"isoformId":"Q01826-2"},{"database":"PDB","id":"1YSE","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=353-490"}]},{"database":"PDB","id":"2L1P","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=179-250"}]},{"database":"PDB","id":"2MW8","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=641-707"}]},{"database":"PDB","id":"2O49","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=367-452"}]},{"database":"PDB","id":"2O4A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=367-452"}]},{"database":"PDB","id":"3NZL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"A=179-250"}]},{"database":"PDB","id":"3TUO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C/D=71-171"}]},{"database":"PDB","id":"6LFF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A/B=368-452"}]},{"database":"PDBsum","id":"1YSE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L1P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MW8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2O49","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2O4A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NZL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3TUO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6LFF","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112211","properties":[{"key":"Interactions","value":"132"}]},{"database":"DIP","id":"DIP-48757N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q01826","properties":[{"key":"Number of interactors","value":"2025"}]},{"database":"IntAct","id":"Q01826","properties":[{"key":"Interactions","value":"81"}]},{"database":"MINT","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-SATB1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000399518","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q01826","properties":[{"key":"glycosylation","value":"2 sites, 2 glycans"}]},{"database":"GlyGen","id":"Q01826","properties":[{"key":"glycosylation","value":"2 sites, 2 O-linked glycans (2 sites)"}]},{"database":"iPTMnet","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SATB1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"417747","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000399518","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58001","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01826-1"},{"database":"ProteomicsDB","id":"58002","properties":[{"key":"Description","value":"-"}],"isoformId":"Q01826-2"},{"database":"Pumba","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"11251","properties":[{"key":"antibodies","value":"542 antibodies from 46 providers"}]},{"database":"DNASU","id":"6304","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000338745.11","properties":[{"key":"ProteinId","value":"ENSP00000341024.5"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000415069.6","properties":[{"key":"ProteinId","value":"ENSP00000390529.2"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000417717.6","properties":[{"key":"ProteinId","value":"ENSP00000399518.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-2"},{"database":"Ensembl","id":"ENST00000454909.6","properties":[{"key":"ProteinId","value":"ENSP00000399708.2"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000457005.6","properties":[{"key":"ProteinId","value":"ENSP00000398072.2"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000700177.1","properties":[{"key":"ProteinId","value":"ENSP00000514845.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000700178.1","properties":[{"key":"ProteinId","value":"ENSP00000514846.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000700179.1","properties":[{"key":"ProteinId","value":"ENSP00000514847.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000700180.1","properties":[{"key":"ProteinId","value":"ENSP00000514848.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000866365.1","properties":[{"key":"ProteinId","value":"ENSP00000536424.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000866366.1","properties":[{"key":"ProteinId","value":"ENSP00000536425.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000866368.1","properties":[{"key":"ProteinId","value":"ENSP00000536427.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000866369.1","properties":[{"key":"ProteinId","value":"ENSP00000536428.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000920135.1","properties":[{"key":"ProteinId","value":"ENSP00000590194.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000920137.1","properties":[{"key":"ProteinId","value":"ENSP00000590196.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-2"},{"database":"Ensembl","id":"ENST00000941468.1","properties":[{"key":"ProteinId","value":"ENSP00000611527.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-2"},{"database":"Ensembl","id":"ENST00000941469.1","properties":[{"key":"ProteinId","value":"ENSP00000611528.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-1"},{"database":"Ensembl","id":"ENST00000941470.1","properties":[{"key":"ProteinId","value":"ENSP00000611529.1"},{"key":"GeneId","value":"ENSG00000182568.19"}],"isoformId":"Q01826-2"},{"database":"GeneID","id":"6304","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6304","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000338745.11","properties":[{"key":"ProteinId","value":"ENSP00000341024.5"},{"key":"RefSeqNucleotideId","value":"NM_002971.6"},{"key":"RefSeqProteinId","value":"NP_002962.1"}]},{"database":"UCSC","id":"uc003cbh.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q01826-1"},{"database":"AGR","id":"HGNC:10541","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34951","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6304","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6304","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SATB1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10541","properties":[{"key":"GeneName","value":"SATB1"}]},{"database":"HPA","id":"ENSG00000182568","properties":[{"key":"ExpressionPatterns","value":"Group enriched (lymphoid tissue, skeletal muscle)"}]},{"database":"MalaCards","id":"SATB1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"602075","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"619228","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"619229","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000182568","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"684232","properties":[{"key":"Disease","value":"Intellectual disability-epilepsy-dental anomalies-facial dysmorphism syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000182568","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3755","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000008096","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_012559_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"SGHLMKS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10052721at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q01826","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-111465","properties":[{"key":"PathwayName","value":"Apoptotic cleavage of cellular proteins"}]},{"database":"Reactome","id":"R-HSA-4551638","properties":[{"key":"PathwayName","value":"SUMOylation of chromatin organization proteins"}]},{"database":"Reactome","id":"R-HSA-9976102","properties":[{"key":"PathwayName","value":"Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)"}]},{"database":"SignaLink","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000182568","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6304","properties":[{"key":"hits","value":"18 hits in 1170 CRISPR screens"}]},{"database":"CD-CODE","id":"B5B9A610","properties":[{"key":"EntryName","value":"PML body"}]},{"database":"ChiTaRS","id":"SATB1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"SATB1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6304","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q01826","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q01826","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q01826","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000182568","properties":[{"key":"ExpressionPatterns","value":"Expressed in orbitofrontal cortex and 220 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q01826","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0000792","properties":[{"key":"GoTerm","value":"C:heterochromatin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0016604","properties":[{"key":"GoTerm","value":"C:nuclear body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33513338"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10800076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18408014"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18408014"}]},{"database":"GO","id":"GO:0016605","properties":[{"key":"GoTerm","value":"C:PML body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18408014"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0140297","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001227","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription repressor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:NTNU_SB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15851481"}]},{"database":"GO","id":"GO:0003690","properties":[{"key":"GoTerm","value":"F:double-stranded DNA binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1505028"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:NTNU_SB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15851481"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:NTNU_SB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15851481"}]},{"database":"GO","id":"GO:0006325","properties":[{"key":"GoTerm","value":"P:chromatin organization"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1505028"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33513338"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd11585","properties":[{"key":"EntryName","value":"SATB1_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000070","properties":[{"key":"EntryName","value":"DNA-binding protein SATB"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.260.40:FF:000003","properties":[{"key":"EntryName","value":"DNA-binding protein SATB"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.10.260.70:FF:000001","properties":[{"key":"EntryName","value":"DNA-binding protein SATB"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.710:FF:000001","properties":[{"key":"EntryName","value":"DNA-binding protein SATB"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.260.40","properties":[{"key":"EntryName","value":"lambda repressor-like DNA-binding domains"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.260.70","properties":[{"key":"EntryName","value":"SATB, CULT domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.710","properties":[{"key":"EntryName","value":"SATB, ubiquitin-like oligomerisation domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003350","properties":[{"key":"EntryName","value":"CUT_dom"}]},{"database":"InterPro","id":"IPR032355","properties":[{"key":"EntryName","value":"CUTL"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR010982","properties":[{"key":"EntryName","value":"Lambda_DNA-bd_dom_sf"}]},{"database":"InterPro","id":"IPR039673","properties":[{"key":"EntryName","value":"SATB1/SATB2"}]},{"database":"InterPro","id":"IPR038216","properties":[{"key":"EntryName","value":"SATB_CUTL_sf"}]},{"database":"InterPro","id":"IPR038224","properties":[{"key":"EntryName","value":"SATB_ULD_sf"}]},{"database":"InterPro","id":"IPR032392","properties":[{"key":"EntryName","value":"ULD"}]},{"database":"PANTHER","id":"PTHR15116","properties":[{"key":"EntryName","value":"DNA-BINDING PROTEIN SATB FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15116:SF14","properties":[{"key":"EntryName","value":"DNA-BINDING PROTEIN SATB1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02376","properties":[{"key":"EntryName","value":"CUT"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF16557","properties":[{"key":"EntryName","value":"CUTL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16534","properties":[{"key":"EntryName","value":"ULD"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01109","properties":[{"key":"EntryName","value":"CUT"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47413","properties":[{"key":"EntryName","value":"lambda repressor-like DNA-binding domains"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51982","properties":[{"key":"EntryName","value":"CMP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51042","properties":[{"key":"EntryName","value":"CUT"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51983","properties":[{"key":"EntryName","value":"CUTL"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD","length":763,"molWeight":85957,"crc64":"D4FE09B09FB7683B","md5":"1065CE64154D35C19CC10CBA5EFCEADE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":2,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"PTM":3,"DISEASE":2,"SIMILARITY":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Domain":2,"DNA binding":3,"Region":4,"Motif":2,"Compositional bias":3,"Binding site":3,"Site":1,"Modified residue":3,"Cross-link":2,"Alternative sequence":1,"Natural variant":20,"Mutagenesis":27,"Beta strand":5,"Helix":19,"Turn":2},"uniParcId":"UPI0000000C35"}}